Location | Data structure | Type of test | CI/power | P value | Comparison |
---|---|---|---|---|---|

a | Normally distributed | One-way ANOVA | 0.97 | <0.0001 | Grp expression in midbrain subregions |

Normally distributed | Tukey’s post hoc | 6.508 to 17.74 | <0.0001 | Grp IF vs. PN/PIF | |

Normally distributed | Tukey’s post hoc | 34.77 to 46 | <0.0001 | Grp IF vs. PBP | |

Normally distributed | Tukey’s post hoc | 35.1 to 46.33 | <0.0001 | Grp IF vs. SNc-V | |

Normally distributed | Tukey’s post hoc | 57.26 to 68.49 | <0.0001 | Grp IF vs. SNc-D | |

Normally distributed | Tukey’s post hoc | 22.65 to 33.88 | <0.0001 | Grp PN/PIF vs. PBP | |

Normally distributed | Tukey’s post hoc | 22.97 to 34.2 | <0.0001 | Grp PN/PIF vs. SNc-V | |

Normally distributed | Tukey’s post hoc | 45.13 to 56.37 | <0.0001 | Grp PN/PIF vs. SNc-D | |

Normally distributed | Tukey’s post hoc | –5.292 to 5.942 | 0.9998 | Grp PBP vs. SNc-V | |

Normally distributed | Tukey’s post hoc | 16.87 to 28.1 | <0.0001 | Grp PBP vs. SNc-D | |

Normally distributed | Tukey’s post hoc | 16.55 to 27.78 | <0.0001 | Grp SNc-V vs. SNcD | |

b | Normally distributed | One-way ANOVA | 0.96 | <0.0001 | Neurod6 expression in midbrain subregions |

Normally distributed | Tukey’s post hoc | –0.4177 to 9.918 | 0.0842 | Neurod6 IF vs. PN/PIF | |

Normally distributed | Tukey’s post hoc | 16.28 to 26.62 | <0.0001 | Neurod6 IF vs. PBP | |

Normally distributed | Tukey’s post hoc | 34.69 to 45.03 | <0.0001 | Neurod6 IF vs. SNc-V | |

Normally distributed | Tukey’s post hoc | 35.82 to 46.16 | <0.0001 | Neurod6 IF vs. SNc-D | |

Normally distributed | Tukey’s post hoc | 11.53 to 21.87 | <0.0001 | Neurod6 PN/PIF vs. | |

Normally distributed | Tukey’s post hoc | PBP | |||

Normally distributed | Tukey’s post hoc | 29.94 to 40.28 | <0.0001 | Neurod6 PN/PIF vs. SNc-V | |

Normally distributed | Tukey’s post hoc | 31.07 to 41.41 | <0.0001 | Neurod6 PN/PIF vs. SNc-D | |

Normally distributed | Tukey’s post hoc | 13.24 to 23.58 | <0.0001 | Neurod6 PBP vs. SNc-V | |

Normally distributed | Tukey’s post hoc | 14.37 to 24.71 | <0.0001 | Neurod6 PBP vs. SNc-D | |

Normally distributed | Tukey’s post hoc | –4.043 to 6.293 | 0.9699 | Neurod6 SNc-V vs. SNc-D | |

c | Normally distributed | One-way ANOVA | 0.522 | 0.036 | Grp expression by age |

Normally distributed | Tukey’s post hoc | –1.112 to 2.462 | 0.5636 | Grp 2 wk vs. 8 wk | |

Normally distributed | Tukey’s post hoc | –3.087 to 0.4872 | 0.1603 | Grp 2 wk vs. 16 wk | |

Normally distributed | Tukey’s post hoc | –3.762 to – 0.1878 | 0.0316 | Grp 8 wk vs. 16 wk | |

d | Normally distributed | One-way ANOVA | 0.56 | 0.0236 | Neurod6 expression by age |

Normally distributed | Tukey’s post hoc | –2.859 to 1.109 | 0.4655 | Neurod6 2 wk vs. 8 wk | |

Normally distributed | Tukey’s post hoc | –4.384 to – 0.4162 | 0.0201 | Neurod6 2 wk vs. 16 wk | |

Normally distributed | Tukey’s post hoc | –3.509 to 0.4588 | 0.1351 | Neurod6 8 wk vs. 16 wk | |

e | Normally distributed | Unpaired t test | –7.68 to 3.147 | 0.3728 | Grp IF M vs. F |

f | Normally distributed | Unpaired t test | –12.78 to 0.4155 | 0.0634 | Grp PN/PIF M vs. F |

g | Normally distributed | Unpaired t test | –1.924 to 4.89 | 0.3549 | Grp PBP M vs. F |

h | Normally distributed | Unpaired t test | –7.321 to 5.188 | 0.7119 | Grp SNCv M vs. F |

i | Normally distributed | Unpaired t test | –0.6657 to 1.199 | 0.5383 | Grp SNCd M vs. F |

j | Normally distributed | Unpaired t test | –13.48 to 4.412 | 0.2852 | Neurod6 IF M vs. F |

k | Normally distributed | Unpaired t test | –8.615 to 3.682 | 0.3924 | Neurod6 PN/PIF M vs. F |

l | Normally distributed | Unpaired t test | –1.028 to 2.095 | 0.4642 | Neurod6 PBP M vs. F |

m | Normally distributed | Unpaired t test | –2.251 to 0.1514 | 0.0801 | Neurod6 SNCv M vs. F |

n | Negative binomial | Likelihood ratio test | n/a | 0.5113 | Neurod6 M vs. F RNASeq data |

o | Negative binomial | Likelihood ratio test | n/a | 0.6835 | Grp M vs. F RNASeq data |

p | Normally distributed | Unpaired t test | –9.156 to –1.532 | 0.0075 | Vm – SNc vs. NEXCre |

q | Normally distributed | Unpaired t test | –1222 to –729.4 | <0.0001 | Rm – SNc vs. NEXCre |

r | Normally distributed | Unpaired t test | 23.67 to 43.99 | <0.0001 | Cm – SNc vs. NEXCre |

s | Normally distributed | Unpaired t test | 11.3 to 21.88 | <0.0001 | AP height – SNc vs. NEX-Cre |

t | Normally distributed | Unpaired t test | 3.372 to 9.524 | 0.0002 | AHP – SNc vs. NEXCre |

u | Normally distributed | Unpaired t test | 6.564 to 10.49 | <0.0001 | Sag – SNc vs. NEXCre |

v | Normally distributed | Unpaired t test | 4.295 to 7.773 | <0.0001 | Rebound – SNc vs. NEX-Cre |

w | Normally distributed | One-way ANOVA | 0.85 | 0.0002 | Cylinder test |

Normally distributed | Tukey’s post hoc | 6.33 to 55.07 | 0.0163 | Saline vs. 6-OHDA paw | |

Normally distributed | Tukey’s post hoc | –55.27 to –6.53 | 0.0157 | Saline vs. both paws | |

Normally distributed | Tukey’s post hoc | –85.97 to –37.23 | 0.0002 | 6-OHDA vs. both paws | |

x | Normally distributed | Paired one-way ANOVA | 0.96 | <0.0001 | Cell population survival |

Normally distributed | Dunnett’s post hoc | –69.31 to –34.69 | 0.0022 | All TH vs. ^{+}Grp-/ Neurod6
^{+} | |

Normally distributed | Dunnett’s post hoc | –6.01 to 15.16 | 0.3169 | All TH vs. ^{+}Grp
^{+}/ Neurod6
^{+} | |

Normally distributed | Dunnett’s post hoc | 2.07 to 15.78 | 0.0246 | All TH vs. ^{+}Grp-^{+}/ Neurod6 | |

Normally distributed | Dunnett’s post hoc | 0.6149 to 15.14 | 0.0403 | All TH vs. ^{+}Lypd1
^{+}/Neurod6- | |

y | Normally distributed | Paired t test | –3.593 to 3.043 | 0.8091 | Lypd1
^{+}/Neurod6^{+} saline vs. 6-OHDA |