Mean number of days/reinforcers to reach criteria
| Days | RNF | |||
|---|---|---|---|---|
| WT | KO | WT | KO | |
| Cocaine FR1 baseline | 4.1 ± 0.6 | 3.9 ± 0.6 | 31.4 ± 4.1 | 25.6 ± 1.8 |
| Cocaine FR1 extinction | 2.6 ± 0.4 | 2.1 ± 0.2 | 12.1 ± 1.7 | 12.3 ± 1.8 |
| Cocaine FR1 re-baseline | 2.3 ± 0.6 | 2.4 ± 0.5 | 34.7 ± 4.3 | 42.2 ± 9.0 |
| Liquid food FR1 baseline | 2.9 ± 0.3 | 5.0 ± 0.7* | 118.1 ± 5.8 | 92.1 ± 9.0* |
| Liquid food FR1 extinction | 1.6 ± 0.2 | 1.3 ± 0.2 | 49.6 ± 5.9 | 42.6 ± 5.8 |
| Liquid food FR1 re-baseline | 2.9 ± 1.1 | 1.5 ± 0.3 | 156.3 ± 21.3 | 118.8 ± 8.6 |
Mice were trained with either cocaine or liquid food under FR1 schedule of reinforcement. PICK1 KO mice showed significantly lower liquid food reinforcements at FR1 acquisition criteria which was also reached slower than wild-type mice; unpaired t test; data are group mean ± SEM. Cocaine: nWT = 8 and nKO = 8; liquid food: nWT = 9 and nKO = 10.