Table 1.

Intrinsic properties of TG neurons from adult WT, HET, and TRESK KO mice

	Diameter, μm	Capacitance, pF	R_in, MΩ	V_rest, mV	Rheobase, pA	AP threshold, mV	AP amplitude, mV	AP half-width, ms	AHP amplitude, mV	Cell number
Small IB4-negative neurons
WT	18.3 ± 0.6	18.0 ± 1.6	1249 ± 126	−50.8 ± 1.1	47 ± 10	−14.7 ± 1.9	104.5 ± 3.0	5.3 ± 0.6	19.6 ± 0.9	28
HET	18.6 ± 0.5	16.8 ± 1.8	1172 ± 74	−52.8 ± 1.1	45 ± 9	−16.4 ± 1.4	105.6 ± 1.5	3.5 ± 0.4	17.3 ± 1.0	16
KO^a	18.1 ± 0.6	17.3 ± 1.7	1849 ± 262^*	−50.1 ± 1.3	18 ± 4**	−18.5 ± 1.7	98.9 ± 2.7	4.7 ± 0.5	17.5 ± 1.8	17
Small IB4-positive neurons
WT	19.2 ± 0.5	20.0 ± 1.2	997 ± 99	−53.3 ± 1.6	103 ± 12	−10.7 ± 2.6	110.2 ± 4.1	5.4 ± 0.8	19.8 ± 0.9	14
HET	22.5 ± 0.7	20.6 ± 1.6	1080 ± 149	−54.7 ± 2.0	99 ± 11	16.1 ± 1.9	112.2 ± 2.8	5.7 ± 0.7	17.2 ± 1.0	17
KO	20.1 ± 1.0	22.8 ± 2.9	1507 ± 205^*	−53.4 ± 1.4	70 ± 10^*	13.6 ± 1.4	107.8 ± 3.8	6.9 ± 0.7	18.2 ± 2.2	14
Medium-sized neurons
WT	30.8 ± 0.2	40.6 ± 2.5	593 ± 110	−57.8 ± 0.9	243 ± 46	15.0 ± 2.5	119.5 ± 3.0	4.9 ± 0.5	16.6 ± 0.2	16
KO	29.3 ± 0.1	40.2 ± 2.7	754 ± 108	−56.3 ± 1.1	207 ± 30	14.7 ± 1.8	113.5 ± 3.5	5.0 ± 0.7	17.6 ± 0.3	21

↵*p < 0.05, **p < 0.01; one-way ANOVA with post hoc Bonferroni test, compared with the corresponding WT and HET groups.
↵a Neurons that exhibit spontaneous APs at V_rest are not included.