Table 4.

[DA]ECvalues (mean ± SEM) under different conditions

SpaceDAT distribution[DA]EC ± Δ [DA]EC (nM)
TonicPhasic
Well-mixed DAa8.16 ± 0.928.29 ± 1.41
Ellipsoid geometry8.21 ± 0.858.33 ± 1.44
Complex space
    Case 1Uniformb7.54 ± 0.866.93 ± 1.92
    Case 2Nonuniformc16.59 ± 1.2614.19 ± 2.44
    Case 3Sharp bimodald33.12 ± 3.1329.65 ± 4.49
    Case 4Sharp bimodald32.49 ± 2.8632.89 ± 3.68
  • a Space/structure-independent. All other cases are in realistic DA neuronal geometry.

  • b DAT densities for uniform and nonuniform (bimodal) distributions; see Table 2.

  • c Case 2 (ρh = 6339/μm2 and ρl = 50/μm2).

  • d Cases 3 and 4 (ρh = 30,000/μm2 and ρl = 50/μm2; see Figs. 2 and 11).