Parameters and properties used in MCell simulations
| Parameter | Value | Unit |
|---|---|---|
| DA diffusion coefficienta | 4.00 × 10−6 | cm2/s |
| Vesicle release probabilityb | 0.06 | |
| Average firing rate of DA neuronsc | 4.00 | Hz |
| DA released per release event d | 3250 | n |
| OF → OF* rate constant (k12)e | 9.60 × 106 | M−1s−1 |
| OF* → IF* rate constant (k23)e | 20.00 | s−1 |
| IF* → IF rate constant (k34)e | 5.00 | s−1 |
| IF ↔ OF forward rate constant (k41)e | 2.00 | s−1 |
| IF ↔ OF reverse rate constant (k14)e | 8.00 | s−1 |
| Total axonal surface areaf | 337.16 | μm2 |
| Uniform DAT surface density, ρ(DAT)f,g | 800 | 1/µm2 |
| High DAT surface density, ρh(DAT)f,h | 6,339 | 1/µm2 |
| Low DAT surface density, ρl(DAT)i | 50 | 1/µm2 |
| Very high DAT surface density, ρh2(DAT)j | 30,000 | 1/µm2 |
| DA density of neurons, IDA | 9.3 | μg/cm3 |
| Ratio of the total DA released per AP, R | 0.05% | |
| Density of DA terminals, ρterm | 0.104 | 1/μm3 |
↵a From Rooney and Wallace (2015).
↵b Reported in Dreyer et al. (2010)
↵c See Dreyer et al. (2010).
↵d See Pothos et al. (1998).
↵e Estimated from molecular computations.
↵f Derived from Block et al. (2015).
↵g Case 1 in Fig. 2.
↵h High-density region in case 21; see Fig. 2.
↵i Low-density region in cases 2–4.
↵j Very-high-density region in cases 3 and 4.