Statistical analysis
| Figure | Group | Parameter | n | CI95 | Data structure | Comparison | Type of test | p/r 2 value |
|---|---|---|---|---|---|---|---|---|
| 5 | VWT/no-MD and VWT/MD-reopening | [A] no-MD – VA % gain[B] MD – VA % gain | 56 | [9.692; 53.92][11.10; 57.88] | Normal distributionNormal distribution | [A] vs [B] | Unpaired t test | p = 0.8328 |
| 6A | VWT/no-MD | [A] standard VA[B] long-term VA | 55 | [0.4854; 0.6263][0.5755; 0.8913] | Normal distributionNormal distribution | [A] vs [B] | Paired t test | p = 0.0171* |
| 6A | VWT/MD(-reopening) | [A] standard VA[B] VA during MD[C] long-term VA | 11/611/66 | [0.5927; 0.6849][0.5339; 0.7873][0.7901; 0.9986] | Normal distributionAssumed normal distributionNormal distribution | [A] vs [B] (11/11)[B] vs [C] (6/6)[A] vs [C] (6/6) | Paired t testPaired t testPaired t test | p = 0.7291p = 0.0471*p = 0.0088** |
| 6B | VWT/no-MD | [A] standard OPT thr[B] long-term OPT thr | 55 | [0.3822; 0.4110][0.3763: 0.4101] | Normal distributionAssumed normal distribution | [A] vs [B] | Paired t test | p = 0.3310 |
| 6B | VWT/MD | [A] standard OPT thr[B] OPT thr during MD[C] long-term OPT thr | 11/611/66 | [0.3831; 0.4072][0.4220; 0.4646][0.3795; 0.4363] | Normal distributionNormal distributionNormal distribution | [A] vs [B] (11/11)[B] vs [C] (6/6)[A] vs [C] (6/6) | Paired t testPaired t testPaired t test | p = 0.0002 ***p = 0.0289*p = 0.0783 |
| 6D | VWT/no-MD | [A] standard VA/OPT thr[B] long-term VA/OPT thr | 55 | NANA | NANA | VA vs OPT thrVA vs OPT thr | CorrelationCorrelation | r 2 = 0.2210r 2 = 0.2347 |
| 6D | VWT/MD(-reopening) | [A] standard VA/OPT thr[B] VA/OPT thr during MD[C] long-term VA/OPT thr | 11116 | NANANA | NANANA | VA vs OPT thrVA vs OPT thrVA vs OPT thr | CorrelationCorrelationCorrelation | r 2 = 0.0026r 2 = 0.0180r 2 = 0.0266 |
| 7C | VWT/no-MD | [A] standard VA[B] long-term VA | 55 | NANA | NANA | VA vs s/trialVA vs s/trial | CorrelationCorrelation | r 2 = 0.0741r 2 = 0.4973 |
| 7C | VWT/MD(-reopening) | [A] standard VA[B] VA during MD[C] long-term VA | 11116 | NANANA | NANANA | VA vs s/trialVA vs s/trialVA vs s/trial | CorrelationCorrelationCorrelation | r 2 = 0.1353r 2 = 0.1131r 2 = 0.0289 |
| 9A | VWT andSC-OI | [A] VWT/no-MD-OI[B] VWT/MD-OI[C] SC/no-MD-OI[D] SC/MD-OI | 4554 | [0.2754; 0.5196][-0.0677;0.1597][0.2492; 0.3908][0.04208; 0.1829] | UnknownNormal distributionNormal distributionUnknown | [A] vs [B][C] vs [D][A] vs [C][B] vs [D] | Mann–WhitneyMann–WhitneyMann–WhitneyMann–Whitney | p = 0.0159*p = 0.0159*p = 0.2187p = 0.2663 |
| 9B | VWT andSC-OI | [A] VWT/no-MD-OI, contra[B] VWT/no-MD-OI, ipsi[C] VWT/MD-OI, contra[D] VWT/MD-OI, ipsi[E] SC/no-MD-OI, contra[F] SC/no-MD-OI, ipsi[G] SC/MD-OI, contra[H] SC/MD-OI, ipsi | 44555544 | [1.649; 2.286][0.8821; 1.013][0.8455; 1.946][0.7713; 2.373][1.325; 1.915][0.7865; 1.150][0.7516; 1.878][0.9528; 1.487] | UnknownUnknownNormal distributionNormal distributionNormal distributionNormal distributionUnknownUnknown | [A] vs [B][C] vs [D][E] vs [F][G] vs [H][A] vs [C][B] vs [D][E] vs [G][F] vs [H] | Mann–WhitneyMann–WhitneyMann–WhitneyMann–WhitneyMann–WhitneyMann–WhitneyMann–WhitneyMann–Whitney | p = 0.0286*p = 0.8413p = 0.0079**p = 0.6857p = 0.0317*p = 0.1905p = 0.2857p = 0.0851 |
The table lists from left to right the figures referred to, groups compared (group), parameters analyzed (parameter), number of animals (n), lower (left) and upper (right) 95% confidence interval of the mean (CI95), distribution of the values (data structure), comparisons of (sub)groups abbreviated as indicated in the parameter column (comparison), test applied for the comparison (type of test), and statistical readout (p/r 2 value). OPT thr, OPT threshold; ipsi and contra, ipsilateral and contralateral eye; NA, not assessable; s/trial, seconds required per correct trial near the break. Significance levels were set as *p < 0.05; **p < 0.01; ***p < 0.001.