Top 10 canonical pathways and upregulators identified using IPA analysis in striatum of Q175 under TRF regimen
| Ingenuity canonical pathways | −log (p value) |
|---|---|
| G protein-coupled receptor signaling | 7.65 |
| cAMP-mediated signaling | 6.73 |
| Glutamate receptor signaling | 6.08 |
| Neuropathic pain signaling in dorsal horn neurons | 5.02 |
| Gαi signaling | 4.94 |
| Synaptic long-term potentiation | 3.38 |
| Gαq signaling | 3.03 |
| iNOS signaling | 2.88 |
| CREB signaling in neurons | 2.87 |
| Serotonin receptor signaling | 2.77 |
| Upstream regulator | −log (p value) |
| BDNF | 13.41 |
| CREB1 | 12.27 |
| Cocaine | 11.87 |
| CNTF | 11.14 |
| HTT | 10.82 |
| TET1 | 10.40 |
| GDNF | 9.74 |
| ADCYAP1R1 | 9.72 |
| Dalfampridine | 8.95 |
| Haloperidol | 8.90 |