Table 3.

Multicomparisons of excitatory and inhibitory synaptic transmission across layers.

ComparisonsEPSC chargesEPSC frequencysEPSC amplitudesIPSC chargesIPSC frequencysIPSC amplitudeE/I ratio
P14
    KW-ANOVA*p < 0.001*p < 0.001p = 0.8*p < 0.001*p < 0.001*p = 0.007*p < 0.001
    M-W U
        L2/3 vs. L4p = 0.03*p = 0.007p = 0.01p = 0.07p = 0.1*p < 0.001
        L2/3 vs. L5p = 0.7p = 0.9p = 0.6p = 0.4*p = 0.005p = 0.5
        L2/3 vs. L6p = 0.01p = 0.01*p < 0.001*p < 0.001*p = 0.004*p = 0.001
        L4 vs. L5p = 0.08p = 0.09p = 0.07p = 0.06p = 0.3p = 0.01
        L4 vs. L6*p < 0.001*p < 0.001*p = 0.005*p = 0.003p = 0.1p = 0.07
        L5 vs. L6p = 0.02p = 0.04*p < 0.001*p < 0.001p = 0.2p = 0.1
P17
    KW-ANOVA*p = 0.01*p = 0.001p = 0.8*p = 0.001*p = 0.005p = 0.8p = 0.07
    M-W U
        L2/3 vs. L4p = 0.2p = 0.09p = 0.3p = 0.2
        L2/3 vs. L5p = 0.6p = 0.2p = 0.2p = 0.4
        L2/3 vs. L6p = 0.03p = 0.02p = 0.01p = 0.04
        L4 vs. L5p = 0.08*p = 0.005p = 0.8p = 0.7
        L4 vs. L6*p = 0.005*p < 0.001*p = 0.001*p = 0.002
        L5 vs. L6p = 0.1p = 0.1*p = 0.001*p = 0.003
P21
    KW-ANOVAp = 0.1p = 0.2p = 0.5*p = 0.002*p = 0.009p = 0.8p = 0.4
    M-W U
        L2/3 vs. L4p = 0.6p = 0.6
        L2/3 vs. L5p = 0.1p = 0.08
        L2/3 vs. L6p = 0.1p = 0.3
        L4 vs. L5p = 0.1p = 0.08
        L4 vs. L6*p < 0.001p = 0.02
        L5 vs. L6*p < 0.001*p < 0.001
P30
    KW-ANOVA*p < 0.001*p < 0.001p = 0.1p = 0.07*p = 0.01*p = 0.03p = 0.2
    M-W U
        L2/3 vs. L4p = 0.1p = 0.04p = 0.3*p = 0.004
        L2/3 vs. L5p = 0.8p = 0.5p = 0.7p = 0.1
        L2/3 vs. L6*p = 0.004*p = 0.001p = 0.03p = 0.8
        L4 vs. L5p = 0.2p = 0.01p = 0.7p = 0.1
        L4 vs. L6*p < 0.001*p < 0.001*p = 0.004p = 0.07
        L5 vs. L6*p = 0.007p = 0.02p = 0.02p = 0.4

  • Development: sEPSCs and sIPSCs; multiple comparisons across layers. *Statistically significant. Only p values <0.008 are considered significant due to Bonferroni correction for multiple comparisons.