Changes in excitatory and inhibitory synaptic transmission after mDEO expressed as % change from control neurons of the hemisphere contralateral to the open eye.
| Layer | sEPSC charge | sEPSC frequency | sEPSC amplitude | sIPSC charge | sIPSC frequency | sIPSC amplitude | E/I ratio | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| mDEO P17 | mDEO P21 | mDEO P17 | mDEO P21 | mDEO P17 | mDEO P21 | mDEO P17 | mDEO P21 | mDEO P17 | mDEO P21 | mDEO P17 | mDEO P21 | mDEO P17 | mDEO P21 | |
| L2/3 | 50 ± 6; *p < 0.001 | 73 ± 6; *p = 0.03 | 58 ± 9; p = 0.003 | 99 ± 6; p = 0.9 | 99 ± 10; p = 0.9 | 76 ± 5; *p = 0.01 | 131 ± 23; p = 0.2 | 75 ± 7; *p = 0.02 | 123 ± 16; p = 0.2 | 98 ± 4; p = 0.9 | 108 ± 12; p = 0.6 | 83 ± 5;*p = 0.04 | 40 ± 7; *p < 0.001 | 104 ± 13; p = 0.7 |
| L4 | 120 ± 9; p = 0.2 | 164 ± 18; *p = 0.01 | 97 ± 8; p = 0.8 | 97 ± 9; p = 0.9 | 111 ± 7; p = 0.2 | 130 ± 9; *p = 0.01 | 147 ± 16; *p = 0.01 | 147 ± 16; *p = 0.01 | 101 ± 8; p = 0.9 | 142 ± 16; *p = 0.04 | 134 ± 8; *p = 0.003 | 109 ± 7; p = 0.3 | 72 ± 9; *p = 0.04 | 116 ± 14; p = 0.4 |
| L5 | 132 ± 16; p = 0.15 | 85 ± 16; p = 0.5 | 131 ± 21; p = 0.3 | 72 ± 15; p = 0.5 | 88 ± 5; p = 0.1 | 93 ± 7; p = 0.5 | 80 ± 8; p = 0.2 | 70 ± 9; p = 0.09 | 80 ± 8; p = 0.3 | 87 ± 7; p = 0.2 | 103 ± 8; p = 0.7 | 76 ± 4; *p = 0.04 | 160 ± 29; p = 0.1 | 112 ± 15; p = 0.6 |
| L6 | 78 ± 16; p = 0.4 | 177 ± 33; *p = 0.02 | 71 ± 13; p = 0.2 | 170 ± 19 *p = 0.003 | 99 ± 7; p = 0.9 | 90 ± 5; p = 0.2 | 86 ± 18; p = 0.16 | 97 ± 19; p = 0.9 | 80 ± 14; p = 0.5 | 107 ± 14; p = 0.7 | 106 ± 10; p = 0.6 | 100 ± 8; p = 0.9 | 81 ± 21; p = 0.5 | 171 ± 36; p = 0.06 |
Results are expressed as mean % change ± SEM. *Statistically significant (p < 0.05) by t test.