Developmental changes in excitatory charge, sEPSC frequency, and sEPSC amplitude.
A, Multiple comparisons across ages and KW-ANOVA.
| Layer | Charge (nC) | Frequency (Hz) | Amplitude (pA) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P14 | P17 | P21 | P30 | KW-ANOVA | P14 | P17 | P21 | P30 | KW-ANOVA | P14 | P17 | P21 | P30 | KW-ANOVA | |
| L2/3 | 5.8 ± 0.8 | 10.4 ± 1.9 | 5.6 ± 1.5 | 7.4 ± 1.1 | p = 0.2 | 2.3 ± 0.2 | 3.8 ± 0.6 | 2.9 ± 0.6 | 4.3 ± 0.5 | *p = 0.007 | 21.6 ± 1.2 | 22.2 ± 2.1 | 16.7 ± 1.8 | 16.7 ± 1.7 | *p = 0.02 |
| L4 | 9.4 ± 1.5 | 13.8 ± 2.1 | 6.3 ± 0.7 | 10.2 ± 1.1 | p = 0.06 | 3.6 ± 0.4 | 5.6 ± 0.7 | 3.3 ± 0.5 | 5.8 ± 0.5 | *p = 0.005 | 21.2 ± 1.4 | 19.3 ± 1.2 | 18.2 ± 1.0 | 18.3 ± 1.7 | p = 0.2 |
| L5 | 6.4 ± 1.1 | 7.6 ± 1.1 | 5.4 ± 0.5 | 8.0 ± 1.5 | p = 0.4 | 2.5 ± 0.5 | 2.9 ± 0.4 | 2.9 ± 0.5 | 3.7 ± 0.5 | p = 0.3 | 21.1 ± 1.4 | 21.0 ± 1.8 | 19.7 ± 1.5 | 18.6 ± 1.6 | p = 0.7 |
| L6 | 2.9 ± 0.5 | 4.8 ± 1.0 | 3.6 ± 0.9 | 3.2 ± 0.5 | p = 0.3 | 1.2 ± 0.3 | 2.2 ± 0.5 | 1.7 ± 0.4 | 2.1 ± 0.3 | p = 0.3 | 19.9 ± 1.2 | 19.9 ± 1.1 | 20.0 ± 1.1 | 14.2 ± 0.7 | *p = 0.002 |
Results are expressed as mean ± SEM.