noMD | MD | Condition | |||||
---|---|---|---|---|---|---|---|
PND26 | |||||||
Body weight (BW in g) | 59 ± 1 | 52 ± 1 | t(78) = 6; p < 0.0001 | ||||
Basal CORT (ng/ml) | 57 ± 20 | 178 ± 45 | t(22) = 5.7; p = 0.025 | ||||
GR hippocampus | 1.0 ± 0.3 | 1.0 ± 0.2 | t(15) = 0.23; p = 0.140 | ||||
GR vmPFC | 1.0 ± 0.2 | 2.4 ± 0.6 | t(13) = −2.2; p = 0.049 | ||||
GR striatum | 1.0 ± 0.2 | 1.8 ± 0.6 | t(8) = 0.2; p = 0.749 | ||||
PND29 | noMD VEH | noMD MIF | MD VEH | MD MIF | Condition × treatment | Condition (noMD vs MD) | Treatment (VEH vs MIF) |
Body weight (BW in g) | 75 ± 2 | 72 ± 1 | 65 ± 1 | 64 ± 2 | F(1,28) = 0.4; p = 0.532 | F(1,28) = 47; p < 0.0001 | F(1,28) = 1.9; p = 0.180 |
Basal CORT (ng/ml) | 228 ± 60 | 122 ± 45 | 68 ± 34 | 115 ± 65 | F(1,20) = 2; p = 0.172 | F(1,20) = 2.4;p = 0.140 | F(1,20) = 0.3; p = 0.593 |
GR hippocampus | 1.2 ± 0.2 | 0.8 ± 0.1 | 1.1 ± 0.3 | 1.2 ± 0.2 | F(1,27) = 1.5; p = 0.226 | F(1,27) = 0.35 p = 0.560 | F(1,27) = 0.41; p = 0.525 |
GR vmPFC | 1.2 ± 0.3 | 1.9± 0.6 | 1.4 ± 0.4 | 1.1 ± 0.3 | F(1,24) = 1; p = 0.322 | F(1,24) = 0.4; p = 0.524 | F(1,24) = 3.7; p = 0.545 |
GR striatum | 1.6 ± 0.7 | 2.2 ± 0.8 | 1.3 ± 0.3 | 1.4 ± 0.5 | F(1,20) = 0.2; p = 0.692 | F(1,20) = 0.8; p = 0.370 | F(1,20) = 0.3; p = 0.590 |
PND90 | noMD VEH | noMD MIF | MD VEH | MD MIF | Condition × treatment | Condition (noMD vs MD) | Treatment (VEH vs MIF) |
Body weight (BW in g) | 329 ± 6 | 334 ± 6 | 333 ± 5 | 331 ± 8 | F(1,29) = 1.3; p = 0.262 | F(1,29) = 0.7; p = 0.415 | F(1,29) = 0.8; p = 0.368 |
Basal CORT (ng/ml) | 191 ± 60 | 206 ± 56 | 104 ± 21 | 118 ± 37 | F(1,24) = 0.0; p = 0.991 | F(1,24) = 3.6; p = 0.071 | F(1,24) = 0.10; p = 0.753 |
GR hippocampus | 1.4± 0.4 | 0.9 ± 0.3 | 1.4 ± 0.4 | 0.8 ± 0.2 | F(1,26) = 0.3; p = 0.871 | F(1,26) = 0.4; p = 0.834 | F(1,26) = 3.2; p = 0.9 |
GR vmPFC | 2.2 ± 0.9 | 1.2 ± 0.3 | 1.2 ± 0.3 | 1.3 ± 0.5 | F(1,24) = 0.9; p = 0.350 | F(1,24) = 0.6; p = 0.430 | F(1,24) = 0.8; p = 0.375 |
GR striatum | 1.1 ± 0.8 | 1.8 ± 1 | 1.3 ± 0.5 | 0.6 ± 0.2 | F(1,19) = 1.1; p = 0.300 | F(1,19) = 0.5; p = 0.505 | F(1,19) = 0.0; p = 0.994 |
All animals had been subjected to 24-h MD at PND3 or control treatment. Half of the animals were treated with MIF through oral gavage twice daily on PND26–PND28; the other half received VEH. Data represent mean ± SEM; all groups n = 6–8 animals, except for body weight at PND26, which was determined for all animals.