Outcome measure | Data structure | Type of test | Confidence interval |
---|---|---|---|

a. Survival curve | Nominal data, nonnormal distribution | Log-rank (Mantel–Cox) | 0.03526 to 0.3404 |

b. Action potential firing frequency ACSF | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1: 0.83 to 3.23 Week 6: 0.02 to 2.42 Week 12: 0.01 to 4.10 |

c. Action potential firing frequency KYN | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1: –2.28 to 4.61 Week 6: –1.52 to 1.24 Week 12: –2.46 to 1.90 |

d. sEPSC frequency | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1: 1.01 to 5.74 Week 6: 0.03 to 2.41 Week 12: 0.12 to 2.30 |

e. sEPSC amplitude | Week 1:normal distribution Week 6:normal distribution Week 12:normal distribution | Unpaired t test | Week 1: –4.88 to 6.12 Week 6: –3.93 to 3.56 Week 12: –7.66 to 1.72 |

f. mEPSC frequency | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1: –0.54 to 1.52 Week 6: 0.65 to 2.74 Week 12: 0.30 to 1.81 |

g. mEPSC amplitude | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1: –4.60 to 5.50 Week 6: –4.96 to 0.97 Week 12: –7.66 to 0.69 |

h. PPr | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1:–0.13 to 0.44 Week 6: –0.12 to 0.66 Week 12: –0.10 to 0.21 |

i. Mean A_{5}/A_{1} | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1: –0.24 to 0.27 Week 6: –0.17 to 0.64 Week 12:–0.09 to 0.29 |

j. Input resistance | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1: –2.00 to 1.86 Week 6: –1.12 to 0.75 Week 12: –2.13 to 0.99 |

k. Resting membrane potential | Week 1: normal distribution Week 6: normal distribution Week 12: normal distribution | Unpaired t test | Week 1: –18.72 to 8.75 Week 6: –11.82 to 9.65 Week 12:–11.37 to 7.67 |

l. Heart rate | Normal distribution | Two-way ANOVA | Baseline: –73.56 to 100.80 24 h: –188.60 to –14.23 Week 6: –94.12 to 80.28 Week 12: –86.80 to 99.64 |

m. SDNN | Normal distribution | Two-way ANOVA | Baseline: –0.96 to 0.62 24 h: 0.03 to 1.62 Week 6: –0.78 to 0.79 Week 12: |

n. RMSSD | Normal distribution | Two-way ANOVA | Baseline: –2.63 to 2.11 24 h: –1.87 to 2.97 Week 6: –2.482 to 2.261 Week 12: –0.92 to 0.77 |