Task | Outcome measure | D2R-OE_{PVT} | EGFP_{PVT} | Statistics |
---|---|---|---|---|

OF test | Ambulatory distance | 207 m/60 min | 215 m/60 min | RM ANOVA: FVirus(1,14) = 0.211, p = 0.65, n = 8/8 |

Time in center | 455 ± 176 s of 60 min | 440 ± 238 s of 60 min | RM ANOVA: FVirus(1,14) = 0.02, p = 0.88, n = 8/8 | |

EPM | Open arm time | 147.0 ± 8.4 s | 140.7 ± 11.1 s | t test: p = 0.65, n = 8/8 |

Closed arm time | 109.9 ± 7.3 s | 110.5 ± 7.2 s | t test: p = 0.96, n = 8/8 | |

LD test | Time in light zone (first 5 min) | 130.3 ± 6.7 s | 126.0 ± 9.4 s | t test: p = 0.71, n = 8/8 |

PPI | Startle response | 0.32 ± 0.29 | 0.25 ± 0.09 | t test: p = 0.53, n = 8/8 |

PPI | Mean PPI (pp2,4,8,12,16): 21.3% | Mean PPI (pp2,4,8,12,16): 20.4% | RM ANOVA: Fvirus(1,14) = 0.01 p = 0.92; Fvirusxprepulse(4,14) = 0.51, p = 0.72, n = 8/8 | |

PIT | Pavlovian learning: dipper approach | No effect of virus | RM ANOVA: Fvirus(1,14) = 2.6E-5, p = 0.99; Fvirusxday(1,6) = 0.22, p = 0.96 | |

(outcome specific) | Instrumental response for sucrose solution | No effect of virus | RM ANOVA: Fvirus(1,14) = 0.52, p = 0.48; Fvirusxday(1,10) = 1.5, p = 0.14 | |

Instrumental response for pellets | No effect of virus | RM ANOVA: Fvirus(1,14) = 0.01, p = 0.91; Fvirusxday(1,10) = 0.4, p = 0.92 | ||

Pavlovian transfer score | Same-different: 2.34 ± 1.588 | Same-different: 0.79 ± 1.87 | ANOVA: Fvirus(1,14) = 3.2, p = 0.10, n = 8/8 | |

PR | Break point | 380.0 ± 69.6 presses | 488.0 ± 82.9 presses | t test: p = 0.33 |

Time until drop out | 77.4 ± 11.6 min | 74.8 ± 9.5 min | t test: p = 0.86 | |

Devaluation | Lever press rate: valued–devalued lever | 2.00 ± 0.70 presses/min over 10 min | 2.30 ± 0.84 presses/min over 10 min | RM ANOVA: Fvirus(1,14) = 0.057, p = 0.81; Fvirusxday(1,9) = 0.59, p = 0.80 |

OF, open field; EPM, elevated plus maze; LD, light-dark; PPI, prepulse inhibition; pp, preplus; PIT, Pavlovian-to-instrumental tranfer; PR, progressive ratio.