Table 2.

Summary of behaviors not affected by D2R upregulation in the PVT

TaskOutcome measureD2R-OEPVTEGFPPVTStatistics
OF testAmbulatory distance207 m/60 min215 m/60 minRM ANOVA: FVirus(1,14) = 0.211, p = 0.65, n = 8/8
Time in center455 ± 176 s of 60 min440 ± 238 s of 60 minRM ANOVA: FVirus(1,14) = 0.02, p = 0.88, n = 8/8
EPMOpen arm time147.0 ± 8.4 s140.7 ± 11.1 st test: p = 0.65, n = 8/8
Closed arm time109.9 ± 7.3 s110.5 ± 7.2 st test: p = 0.96, n = 8/8
LD testTime in light zone (first 5 min)130.3 ± 6.7 s126.0 ± 9.4 st test: p = 0.71, n = 8/8
PPIStartle response0.32 ± 0.290.25 ± 0.09t test: p = 0.53, n = 8/8
PPIMean PPI (pp2,4,8,12,16): 21.3%Mean PPI (pp2,4,8,12,16): 20.4%RM ANOVA: Fvirus(1,14) = 0.01 p = 0.92; Fvirusxprepulse(4,14) = 0.51, p = 0.72, n = 8/8
PITPavlovian learning: dipper approachNo effect of virusRM ANOVA: Fvirus(1,14) = 2.6E-5, p = 0.99; Fvirusxday(1,6) = 0.22, p = 0.96
(outcome specific)Instrumental response for sucrose solutionNo effect of virusRM ANOVA: Fvirus(1,14) = 0.52, p = 0.48; Fvirusxday(1,10) = 1.5, p = 0.14
Instrumental response for pelletsNo effect of virusRM ANOVA: Fvirus(1,14) = 0.01, p = 0.91; Fvirusxday(1,10) = 0.4, p = 0.92
Pavlovian transfer scoreSame-different: 2.34 ± 1.588Same-different: 0.79 ± 1.87ANOVA: Fvirus(1,14) = 3.2, p = 0.10, n = 8/8
PRBreak point380.0 ± 69.6 presses488.0 ± 82.9 pressest test: p = 0.33
Time until drop out77.4 ± 11.6 min74.8 ± 9.5 mint test: p = 0.86
DevaluationLever press rate: valued–devalued lever2.00 ± 0.70 presses/min over 10 min2.30 ± 0.84 presses/min over 10 minRM ANOVA: Fvirus(1,14) = 0.057, p = 0.81; Fvirusxday(1,9) = 0.59, p = 0.80
  • OF, open field; EPM, elevated plus maze; LD, light-dark; PPI, prepulse inhibition; pp, preplus; PIT, Pavlovian-to-instrumental tranfer; PR, progressive ratio.