Description | Data structure | Type of test | Statistical value | |
---|---|---|---|---|
a | sIPSC frequency (Fig. 1B) | Normal distribution | t test | t(29) = 0.5388, p = 0.5941 (3–4 weeks); t(29) = 2.116, p = 0.0431 (6–8 weeks) |
b | sIPSC amplitude (Fig. 1C) | Normal distribution | t test; ANOVA | t(29) = 0.5665, p = 0.5754 (3–4 weeks); t(29) = 0.4330, p = 0.6682 (6–8 weeks); age: F(1,58) = 20.27, p < 0.0001 |
c | sIPSC rise time (Fig. 1E) | Normal distribution | ANOVA | F(1,60) = 2.188, p = 0.1443 (WT vs KO) |
d | sIPSC decay time (Fig. 1F) | Normal distribution | ANOVA | F(1,60) = 0.7872, p = 0.3785 (WT vs KO) |
e | IGABA in six to eight weeks (Fig. 2B) | Non-normal distribution | M–W test | p = 0.0282 |
f | Cm in IGABA measurement | Normal distribution | t test | t(36) = 0.4044, p = 0.6883 |
g | Normalized IGABA in six to eight weeks (Fig. 2C) | Non-normal distribution | M–W test | p = 0.0058 |
h | IGABA in three to four weeks (Fig. 2B) | Normal distribution | t test | t(31) = 0.4277, p = 0.8637 |
i | Normalized IGABA in three to four weeks (Fig. 2C) | Non-normal distribution | M–W test | p = 0.5529 |
j | Cm in ITHIP measurement | Normal distribution | t test | t(45) = 0.1597, p = 0.8739 |
k | ITHIP (Fig. 3B) | Normal distribution | t test | t(45) = 2.788, p = 0.0077 |
l | Normalized ITHIP (Fig. 3C) | Normal distribution | t test | t(45) = 2.979, p = 0.0047 |
m | Cm in IBaclofen measurement | Normal distribution | t test | t(28) = 1.533, p = 0.1366 |
n | IBaclofen (Fig. 4B) | Normal distribution | t test | t(28) = 1.182, p = 0.247 |
o | Normalized IBaclofen (Fig. 4C) | Non-normal distribution | M–W test | p = 0.9834 |
p | Ramp-current threshold (Fig. 5A) | Normal distribution | t test | t(23) = 0.1924, p = 0.849 (3–4 weeks); t(22) = 1.064, p = 0.299 (6–8 weeks) |
q | Current-firing curve (Fig. 5B) | ANOVA | F(1,23) = 0.0228, p = 0.881 (3–4 weeks); F(1,22) = 1.320, p = 0.263, (6–8 weeks) | |
r | Step-current threshold (Fig. 5C) | Normal distribution | t test | t(23) = 0.2003, p = 0.843 (3–4 weeks); t(22) = 0.8177, p = 0.4223 (6–8 weeks) |
s | Max. firing rate (Fig. 5D) | Normal distribution | t test | t(23) = 0.69, p = 0.4971 (3–4 weeks); t(22) = 0.9258, p = 0.3646 (6–8 weeks) |
t | Current-firing curve in three to four weeks (Fig. 6B) | ANOVA | F(1,24) = 28.45, p < 0.0001 (WT, before vs THIP); F(1,24) = 14.66, p = 0.0008 (KO, before vs THIP); F(1,24) = 1.199, p = 0.2844 (before, WT vs KO); F(1,24) = 0.0073, p = 0.9328 (THIP, WT vs KO) | |
u | Current-firing curve in six to eight weeks (Fig. 6C) | ANOVA | F(1,30) = 57.87, p < 0.0001 (WT, before vs THIP); F(1,32) = 30.66, p = 0.0008 (KO, before vs THIP); F(1,31) = 1.228, p = 0.2764 (before, WT vs KO); F(1,31) = 4.919, p = 0.0340 (THIP, WT vs KO) | |
v | Step-current threshold (Fig. 6D) | Normal distribution Non-normal distribution | Paired t test Wilcoxon test | t(12) = 7.229, p < 0.0001 (WT); p = 0.0005(KO) |
w | Step-current threshold (Fig. 6E) | Non-normal distribution Normal distribution | Wilcoxon test Paired t test | p < 0.0001 (WT); t(16) = 6.154, p < 0.0001 (KO) |
x | Δ current threshold (Fig. 6F) | Non-normal distribution | M–W test | p = 0.0257 |
y | Slope in three to four weeks (Fig. 6G) | Non-normal distribution | Wilcoxon test | p = 0.0002 (WT) p = 0.0002 (KO) |
z | Slope in six to eight weeks (Fig. 6H) | Normal distribution Non-normal distribution | Paired t test Wilcoxon test | t(15) = 5.761, p < 0.0001 (WT); p = 0.0001 (KO) |
aa | Δ slope (Fig. 6I) | Non-normal distribution | M–W test | p = 0.0063 |