Table 1.

Summary of effects of SMM-189 on LFP and hippocampal SWR activity in mice with mTBI

CA1mPFCS1/V1
Sham + drugmTBI + VEHmTBI + drugSham + drugmTBI + VEHmTBI + drugSham + drugmTBI + VEHmTBI + drug
LFP power spectrumSame as sham + VEHSame as sham + VEHSame as sham + VEHSame as sham + VEHSame as sham + VEHSame as sham + VEHSame as sham + VEHSame as sham + VEHSame as sham + VEH
LFP coherence within areaSame as sham + VEH↑Same as sham + VEHSame as sham + VEHSame as sham + VEHSame as sham + VEHSame as sham + VEH↑↑
LFP coherence with CA1N/AN/AN/ASame as sham + VEHSame as sham + VEHSame as sham + VEHN/AN/AN/A
LFP coherence with S1/V1N/AN/AN/ASame as sham + VEHSame as sham + VEHSame as sham + VEHN/AN/AN/A
SWR frequencySame as sham + VEH↓Same as sham + VEHN/AN/AN/AN/AN/AN/A
SWR relative frequency powerSame as sham + VEHSame as sham + VEHSame as sham + VEHN/AN/AN/AN/AN/AN/A
SWR-associated LFP amplitudeSame as sham + VEHSame as sham + VEH↑Same as sham + VEH↓Same as sham + VEHN/AN/AN/A
θ-γ couplingN/ASame as sham + VEHSame as sham + VEHN/A↑Same as sham + VEHN/AN/AN/A

  • CA1, hippocampal CA1 region; N/A, not applicable; VEH, vehicle; ↑, increase; ↓ , decrease.