Drug | Mean ± SEM | Student’s t | df | p | Levene’s p | Shapiro-Wilk p |
---|---|---|---|---|---|---|
(2.5 µM) | ||||||
DMSO control | 25,868.7 ± 2606.4 | 0.308 | ||||
Valproic acid | 24,120.2 ± 3697.7 | 0.386 | 14 | 0.705 | 0.432 | 0.651 |
Trazodone | 25,239 ± 1494.6 | 0.209 | 14 | 0.837 | 0.109 | 0.068 |
Diazepam | 19,108.0 ± 6247.0 | 0.999 | 14 | 0.335 | 0.133 | 0.034 |
Clemizole | 27,076.0 ± 2289.8 | 0.348 | 14 | 0.733 | 0.594 | 0.863 |
(25 µM) | ||||||
DMSO control | (30,921.1 ± 4311.6) | 0.293 | ||||
Valproic acid | 23,435.8 ± 3465.6 | 1.353 | 14 | 0.197 | 0.324 | 0.75 |
Trazodone | 31,490.0 ± 4857.9 | 0.088 | 14 | 0.931 | 0.932 | 0.188 |
Diazepam | 6908.1 ± 1916.6 | 5.089 | 14 | <0.001 | 0.01 | 0.567 |
Clemizole | 7475.7 ± 3384.2 | 4.278 | 14 | <0.001 | 0.171 | <0.001 |
Larval zebrafish (N = 18 per group) were video recorded during the 10-h night phase and total distance was measured for larva treated with DMSO or with one of four drugs at two concentrations (see Materials and Methods). For DMSO and each drug tested, the table shows distance moved in mm (mean ± SEM), t value, degrees of freedom, and p value (see Results). Data from lower concentration tested (2.5 µM) is shown at top; 25 µM is shown below.