Table 1.

Synaptic and intrinsic properties of CA1 pyramidal cells at 2-4 d after ablation. Values are given as average (Ave) ± standard deviation (SD).

AAV-DTR + DTAAV-DTR aloneDT aloneStatistics
Ave ± SDAve ± SDAve ± SDOne-Way ANOVA
mEPSCIEI (ms)1524.9 ± 933.9890.0 ± 455.21306.5 ± 312.6F(2,20) = 1.76, p = 0.20
Amplitude (pA)22.9 ± 2.921.0 ± 1.120.1 ± 3.9F(2,20) = 2.05, p = 0.16
Decay (ms)4.7 ± 0.95.0 ± 0.95.3 ± 1.7F(2,20) = 0.40, p = 0.67
n (mice/cells)3/83/73/5
mIPSCIEI (ms)181.6 ± 154.4148.2 ± 64.1124.8 ± 46.0F(2,22) = 0.59, p = 0.56
Amplitude (pA)35.1 ± 4.638.0 ± 5.433.5 ± 6.2F(2,22) = 1.36, p = 0.28
Decay (ms)7.5 ± 1.17.5 ± 1.46.9 ± 1.4F(2,22) = 0.39, p = 0.68
n (mice/cells)3/83/83/7
Intrinsic propertiesWhole-cell capacitance (pF)27.8 ± 5.929.9 ± 7.127.1 ± 5.6F(2,22) = 0.41, p = 0.67
Input resistance (MΩ)126 ± 33129 ± 20136 ± 39F(2,22) = 0.18, p = 0.84
Membrane time constant (τw, ms)2.2 ± 0.52.2 ± 0.42.1 ± 0.4F(2,22) = 0.12, p = 0.89