Table 2.

Synaptic and intrinsic properties of CA1 pyramidal cells at 6-8 d after ablation

AAV-DTR + DTAAV-DTR aloneDT aloneStatistics
Ave ± SDAve ± SDAve ± SDOne-way ANOVA
mEPSCIEI (ms)1806.8 ± 805.92465.6 ± 1091.52199.4 ± 1057.2F(2,44) = 1.75, p = 0.19
Amplitude (pA)31.7 ± 4.132.8 ± 5.931.0 ± 7.4F(2,44) = 0.36, p = 0.70
Decay (ms)3.3 ± 0.4#3.7 ± 0.64.5 ± 1.3F(2,44) = 7.05, p < 0.01
n (mice/cells)4/164/154/14
mIPSCIEI (ms)3129.0 ± 3391.5*378.7 ± 433.3120.5 ± 45.7F(2,44) = 10.3, p < 0.01
Amplitude (pA)40.1 ± 8.143.1 ± 7.335.8 ± 6.2F(2,44) = 3.67, p = 0.64
Decay (ms)6.8 ± 1.56.3 ± 0.86.3 ± 0.9F(2,44) = 1.15, p = 0.33
n (mice/cells)4/164/154/14
Intrinsic propertiesWhole-cell capacitance (pF)33.6 ± 6.130.4 ± 6.730.6 ± 6.9F(2,44) = 1.15, p = 0.33
Input resistance (MΩ)148 ± 68115 ± 38100 ± 37F(2,44) = 3.61, p = 0.04
Membrane time constant (τw, ms)1.9 ± 0.62.1 ± 0.62.5 ± 0.8F(2,44) = 2.55, p = 0.09
  • * Significant difference between AAV-DTR + DT and both AAV-DTR alone and DT alone (one-way ANOVA, Tukey’s multiple comparison test).

  • #Significant difference between AAV-DTR + DT and DT alone (one-way ANOVA, Tukey’s multiple comparison test).