Table 2.

Summary of the statistical tests used for analyses and corresponding figure(s)

FigureStatistical test used for analysis
Fig. 2B, ATF4 in rat PCNs
Fig. 2D, LDH in rat PCNs
Fig. 3A,C, ATF4 in APPSwe PCNs
Fig. 6D, Anxiety-like behavior in PS19 mice
Fig. 6H, Fear-based learning and memory in PS19 mice
Fig. 7B, ATF4 in PS19 mice
Fig. 8C,D, P-tau by IHC in PS19 mice
Fig. 8F, CA1 pyramidal cell layer in PS19 mice
Fig. 10A,B, Locomotor activity in APPSwe mice
Fig. 10D, Fear-based retrieval in APPSwe mice
One-way ANOVA;
Bonferroni’s MCT
Fig. 2C, CHOP in rat PCNs
Fig. 3B, SUnSET
Fig. 3C, ATF4 in mouse PCNs
Fig. 6F,G, MWM spatial memory recall in PS19 mice
Fig. 7D, Tau by immunoblot in PS19 mice
Fig. 10F, MWM spatial memory recall in APPSwe mice
Fig. 10G, Exploratory behavior in APPSwe mice
Fig. 10H, Recognition memory in APPSwe mice
Tables 3, 4, Phenotype analysis
t tests (Student's, one-sample, paired samples)
Fig. 4A, PK
Fig. 4B, Body weight in C57BL/6J mice
Fig. 6A-C, Locomotor activity in PS19 mice
Fig. 6E, MWM spatial acquisition in PS19 mice
Fig. 5A, Body weight in PS19 mice
Fig. 9A, Body weight in APPSwe mice
Fig. 10C, Fear conditioning in APPSwe mice
Fig. 10E, MWM spatial acquisition in APPSwe mice
Two-way ANOVA
Linear regression
Two-way RM ANOVA or SPANOVA; Bonferroni’s MCT
Fig. 4C, Survival rate in C57BL/6J mice
Fig. 5B, Survival rate in PS19 mice
Fig. 9B, Survival rate in APPSwe mice
Mantel-Cox