Statistical table
| Figure | Kolmogorov-Smirnov test for normality (p value) | Statistical significance |
|---|---|---|
| Figure 1A
body weight | All groups at all time points are normally distributed (p > 0.05). | Genotype: F(1,29) = 0.10, p = 0.759 diet: F(1,29) = 10.51, p = 0.003 interaction: F(1,29) = 2.68, p = 0.112 |
| Figure 1B
plasma cholesterol | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype: F(1,29) = 2.86, p = 0.103 diet: F(1,29) = 1.58, p = 0.221 interaction: F(1,29) = 2.60, p = 0.119 |
| Figure 1C
plasma triglycerides | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype: F(1,29) = 0.56, p = 0.46 diet: F(1,29) = 2.87, p = 0.102 interaction: F(1,29) = 1.91, p = 0.179 |
| Figure 1D
gonadal fat weight | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype: F(1,29) = 0.18, p = 0.673 diet: F(1,29) = 37.04, p < 0.001 interaction: F(1,29) = 5.01, p = 0.033 |
| Figure 1E
CD68 | E3FAD CTL N/A E3FAD WD > 0.10 E4FAD CTL = 0.004 E4FAD WD > 0.10 | Genotype: F(1,21) = 0.90, p = 0.353 diet: F(1,21) = 11.54, p = 0.003 interaction: F(1,21) = 0.85, p = 0.366 |
| Figure 1F
F4/80 | E3FAD CTL N/A E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype: F(1,21) = .09, p = .768 diet: F(1,21) = 7.02, p = 0.015 interaction: F(1,21) = 1.19, p = 0.288 |
| Figure 1G
glucose (GTT) | All groups at all time points are normally distributed (p > 0.05), except: E4FAD CTL 0 min = 0.002 E4FADWD 15 min = 0.025 E3FAD WD 30 min = 0.011 E4FAD WD 30 min = 0.008 | Genotype: F(1,29) = 0.02, p = 0.886 diet: F(1,29) = 5.03, p = 0.033 interaction: F(1,29) = 0.10, p = 0.750 |
| Figure 1H
GTT AUC | E3FAD CTL = 0.07 E3FAD WD = 0.097 E4FAD CTL > 0.10 E4FAD WD = 0.033 | Genotype: F(1,29) = .06, p = 0.817 diet: F(1,29) = 5.73, p = 0.023 interaction: F(1,29) = 0.12, p = 0.737 |
| Figure 1I
percent glucose change | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype: F(1,29) = .83, p = 0.371 diet: F(1,29) = 3.84, p = 0.059 interaction: F(1,29) = 0.90, p = 0.352 |
|
Figure 2B
Thio-S: entorhinal cortex | E3FAD CTL > 0.10 E3FAD WD = 0.049 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype: F(1,29) = 50.30, p < 0.001 diet: F(1,29) = 6.62, p = 0.016 interaction: F(1,29) = 4.09, p = 0.053 |
|
Figure 2C
Thio-S: subiculum | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype: F(1,29) = 59.40, p < 0.001 diet: F(1,29) = 2.98, p = 0.095 interaction: F(1,29) = 9.75, p = 0.004 |
|
Figure 2D
Thio-S: CA1 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype: F(1,29) = 80.58, p < 0.001 diet: F(1,29) = 4.95, p = 0.034 interaction: F(1,29) = 8.41, p = 0.007 |
|
Figure 2E
Thio-S: CA2/3 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 46.39, p < 0.001 diet: F(1,29) = 7.41, p = 0.011 interaction: F(1,29) = 7.32, p = 0.011 |
|
Figure 3B
Aβ load: entorhinal cortex | E3FAD CTL > 0.10 E3FAD WD = 0.002 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 21.38, p < 0.001 diet: F(1,29) = 7.83, p = 0.009 interaction: F(1,29) = 4.91, p = 0.035 |
|
Figure 3C
Aβ load: subiculum | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 25.40, p < 0.001 diet: F(1,29) = 11.19, p = 0.002 interaction: F(1,29) = 0.11, p = 0.742 |
|
Figure 3D
Aβ load: CA1 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD = 0.036 | Genotype F(1,29) = 37.66, p < 0.001 diet: F(1,29) = 2.91, p = 0.099 interaction: F(1,29) = 2.71, p = 0.110 |
| Figure 3E Aβ load: CA2/3 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 47.27, p < 0.001 diet: F(1,29) = 10.36, p = 0.003 interaction: F(1,29) = 4.48, p = 0.043 |
|
Figure 4B
microglia number: entorhinal cortex | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,27) = 9.78, p = 0.004 diet: F(1,27) = 2.31, p = 0.141 interaction: F(1,27) = 1.05, p = 0.316 |
|
Figure 4C
microglia number: subiculum | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,27) = 42.77, p < 0.001 diet: F(1,27) = 4.20, p = 0.050 interaction: F(1,27) = 4.75, p = 0.038 |
|
Figure 4D
microglia number: CA1 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,27) = 51.42, p < 0.001 diet: F(1,27) = 10.78, p = 0.003 interaction: F(1,27) = 7.97, p = 0.009 |
|
Figure 4E
microglia number: CA2/3 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,27) = 21.64, p < 0.001 diet: F(1,27) = 1.97, p = 0.172 interaction: F(1,27) = 1.90, p = 0.180 |
|
Figure 4F
microglia reactivity: entorhinal cortex | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,27) = 109.10, p < 0.001 diet: F(1,27) = 1.64, p = 0.212 interaction: F(1,27) = 5.52, p = 0.027 |
|
Figure 4G
microglial reactivity: subiculum | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL = 0.07 E4FAD WD < 0.001 | Genotype F(1,27) = 19.70, p < 0.001 diet: F(1,27) = 0.00, p = 0.995 interaction: F(1,27) = 0.51, p = 0.480 |
|
Figure 4H
microglial reactivity: CA1 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD = 0.04 | Genotype F(1,27) = 78.70, p < 0.001 diet: F(1,27) = 5.00, p = 0.034 interaction: F(1,27) = 11.58, p = 0.002 |
|
Figure 4I
microglial reactivity: CA2/3 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,27) = 165.70, p < 0.001 diet: F(1,27) = 21.04, p < 0.001 interaction: F(1,27) = 32.66, p < 0.001 |
|
Figure 5B
astrocyte number: entorhinal cortex | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 3.82, p = 0.060 diet: F(1,29) = 0.29, p = 0.593 interaction: F(1,29) = 0.41, p = 0.528 |
|
Figure 5C
astrocyte number: subiculum | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 9.95, p = 0.004 diet: F(1,29) = 4.79, p = 0.037 interaction: F(1,29) = 1.04, p = 0.316 |
|
Figure 5D
astrocyte number: CA1 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 5.88, p = 0.022 diet: F(1,29) = 3.55, p = 0.069 interaction: F(1,29) = 0.49, p = 0.489 |
|
Figure 5E
astrocyte number: CA2/3 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 1.82, p = 0.188 diet: F(1,29) = 4.26, p = 0.048 interaction: F(1,29) = 0.02, p = 0.894 |
|
Figure 5F
astrocyte reactivity: entorhinal cortex | E3FAD CTL > 0.10 E3FAD WD = 0.004 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 46.97, p < 0.001 diet: F(1,29) = 5.75, p = 0.023 interaction: F(1,29) = 4.82, p = 0.036 |
|
Figure 5G
astrocyte reactivity: subiculum | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL = 0.045 E4FAD WD > 0.10 | Genotype F(1,29) = 27.72, p < 0.001 diet: F(1,29) = 3.13, p = 0.088 interaction: F(1,29) = 0.00, p = 0.989 |
| Figure 5H astrocyte reactivity: CA1 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 87.49, p < 0.001 diet: F(1,29) = 23.82, p < 0.001 interaction: F(1,29) = 2.08, p = 0.160 |
|
Figure 5I
astrocyte reactivity: CA2/3 | E3FAD CTL > 0.10 E3FAD WD > 0.10 E4FAD CTL > 0.10 E4FAD WD > 0.10 | Genotype F(1,29) = 11.68, p = 0.002 diet: F(1,29) = 7.83, p = 0.009 interaction: F(1,29) = 2.405, p = 0.132 |