Table 2.

Statistical table

FigureKolmogorov-Smirnov test for normality (p value)Statistical significance
Figure 1A
body weight
All groups at all time points are normally distributed (p > 0.05).Genotype: F(1,29) = 0.10, p = 0.759
diet: F(1,29) = 10.51, p = 0.003
interaction: F(1,29) = 2.68, p = 0.112
Figure 1B
plasma cholesterol
Genotype: F(1,29) = 2.86, p = 0.103
diet: F(1,29) = 1.58, p = 0.221
interaction: F(1,29) = 2.60, p = 0.119
Figure 1C
plasma triglycerides
Genotype: F(1,29) = 0.56, p = 0.46
diet: F(1,29) = 2.87, p = 0.102
interaction: F(1,29) = 1.91, p = 0.179
Figure 1D
Genotype: F(1,29) = 0.18, p = 0.673
diet: F(1,29) = 37.04, p < 0.001
interaction: F(1,29) = 5.01, p = 0.033
Figure 1E
CD68
Genotype: F(1,21) = 0.90, p = 0.353
diet: F(1,21) = 11.54, p = 0.003
interaction: F(1,21) = 0.85, p = 0.366
Figure 1F
F4/80
Genotype: F(1,21) = .09, p = .768
diet: F(1,21) = 7.02, p = 0.015
interaction: F(1,21) = 1.19, p = 0.288
Figure 1G
glucose (GTT)
All groups at all time points are normally distributed (p > 0.05), except: E4FAD CTL 0 min = 0.002 E4FADWD 15 min = 0.025 E3FAD WD 30 min = 0.011 E4FAD WD 30 min = 0.008Genotype: F(1,29) = 0.02, p = 0.886
diet: F(1,29) = 5.03, p = 0.033
interaction: F(1,29) = 0.10, p = 0.750
Figure 1H
GTT AUC
Genotype: F(1,29) = .06, p = 0.817
diet: F(1,29) = 5.73, p = 0.023
interaction: F(1,29) = 0.12, p = 0.737
Figure 1I
percent glucose change
Genotype: F(1,29) = .83, p = 0.371
diet: F(1,29) = 3.84, p = 0.059
interaction: F(1,29) = 0.90, p = 0.352
Figure 2B
Thio-S: entorhinal cortex
Genotype: F(1,29) = 50.30, p < 0.001
diet: F(1,29) = 6.62, p = 0.016
interaction: F(1,29) = 4.09, p = 0.053
Figure 2C
Thio-S: subiculum
Genotype: F(1,29) = 59.40, p < 0.001
diet: F(1,29) = 2.98, p = 0.095
interaction: F(1,29) = 9.75, p = 0.004
Figure 2D
Thio-S: CA1
Genotype: F(1,29) = 80.58, p < 0.001
diet: F(1,29) = 4.95, p = 0.034
interaction: F(1,29) = 8.41, p = 0.007
Figure 2E
Thio-S: CA2/3
Genotype F(1,29) = 46.39, p < 0.001
diet: F(1,29) = 7.41, p = 0.011
interaction: F(1,29) = 7.32, p = 0.011
Figure 3B
entorhinal cortex
Genotype F(1,29) = 21.38, p < 0.001
diet: F(1,29) = 7.83, p = 0.009
interaction: F(1,29) = 4.91, p = 0.035
Figure 3C
subiculum
Genotype F(1,29) = 25.40, p < 0.001
diet: F(1,29) = 11.19, p = 0.002
interaction: F(1,29) = 0.11, p = 0.742
Figure 3D
CA1
Genotype F(1,29) = 37.66, p < 0.001
diet: F(1,29) = 2.91, p = 0.099
interaction: F(1,29) = 2.71, p = 0.110
Figure 3E
CA2/3
Genotype F(1,29) = 47.27, p < 0.001
diet: F(1,29) = 10.36, p = 0.003
interaction: F(1,29) = 4.48, p = 0.043
Figure 4B
microglia number:
entorhinal cortex
Genotype F(1,27) = 9.78, p = 0.004
diet: F(1,27) = 2.31, p = 0.141
interaction: F(1,27) = 1.05, p = 0.316
Figure 4C
microglia number:
subiculum
Genotype F(1,27) = 42.77, p < 0.001
diet: F(1,27) = 4.20, p = 0.050
interaction: F(1,27) = 4.75, p = 0.038
Figure 4D
microglia number:
CA1
Genotype F(1,27) = 51.42, p < 0.001
diet: F(1,27) = 10.78, p = 0.003
interaction: F(1,27) = 7.97, p = 0.009
Figure 4E
microglia number:
CA2/3
Genotype F(1,27) = 21.64, p < 0.001
diet: F(1,27) = 1.97, p = 0.172
interaction: F(1,27) = 1.90, p = 0.180
Figure 4F
microglia reactivity:
entorhinal cortex
Genotype F(1,27) = 109.10, p < 0.001
diet: F(1,27) = 1.64, p = 0.212
interaction: F(1,27) = 5.52, p = 0.027
Figure 4G
microglial reactivity:
subiculum
Genotype F(1,27) = 19.70, p < 0.001
diet: F(1,27) = 0.00, p = 0.995
interaction: F(1,27) = 0.51, p = 0.480
Figure 4H
microglial reactivity:
CA1
Genotype F(1,27) = 78.70, p < 0.001
diet: F(1,27) = 5.00, p = 0.034
interaction: F(1,27) = 11.58, p = 0.002
Figure 4I
microglial reactivity:
CA2/3
Genotype F(1,27) = 165.70, p < 0.001
diet: F(1,27) = 21.04, p < 0.001
interaction: F(1,27) = 32.66, p < 0.001
Figure 5B
astrocyte number:
entorhinal cortex
Genotype F(1,29) = 3.82, p = 0.060
diet: F(1,29) = 0.29, p = 0.593
interaction: F(1,29) = 0.41, p = 0.528
Figure 5C
astrocyte number:
subiculum
Genotype F(1,29) = 9.95, p = 0.004
diet: F(1,29) = 4.79, p = 0.037
interaction: F(1,29) = 1.04, p = 0.316
Figure 5D
astrocyte number:
CA1
Genotype F(1,29) = 5.88, p = 0.022
diet: F(1,29) = 3.55, p = 0.069
interaction: F(1,29) = 0.49, p = 0.489
Figure 5E
astrocyte number:
CA2/3
Genotype F(1,29) = 1.82, p = 0.188
diet: F(1,29) = 4.26, p = 0.048
interaction: F(1,29) = 0.02, p = 0.894
Figure 5F
astrocyte reactivity:
entorhinal cortex
Genotype F(1,29) = 46.97, p < 0.001
diet: F(1,29) = 5.75, p = 0.023
interaction: F(1,29) = 4.82, p = 0.036
Figure 5G
astrocyte reactivity:
subiculum
Genotype F(1,29) = 27.72, p < 0.001
diet: F(1,29) = 3.13, p = 0.088
interaction: F(1,29) = 0.00, p = 0.989
Figure 5H
astrocyte reactivity:
CA1