Parameter | Main effects (two-way ANOVA) | Group differences (from NaCl-Social) | ||||
---|---|---|---|---|---|---|
Treatment | Rearing | Interaction | NaCl-Isolation | MK801-Social | MK801-Isolation | |
Density of neuropil puncta (Fig. 7) | ||||||
VGLUT1 (Amygdala) | ||||||
Central | — | — | — | n/a | n/a | n/a |
Lateral | ✓(64) | ✓(65) | ✓(66) | — | — | ↑* |
Basolateral | — | — | — | n/a | n/a | n/a |
Basomedial | ✓(67) | ✓(68) | #(69) | n/a | n/a | n/a |
Medial | #(70) | ✓(71) | ✓(72) | — | — | ↑* |
VGLUT1 (PFC) | ||||||
IL+PrL | — | — | — | n/a | n/a | n/a |
Cg1+Cg2 | ✓(73) | ✓(74) | #(75) | n/a | n/a | n/a |
VGAT (Amygdala) | ||||||
Central | — | #(76) | — | n/a | n/a | n/a |
Lateral | — | ✓(77) | — | n/a | n/a | n/a |
Basolateral | #(78) | #(79) | #(80) | n/a | n/a | n/a |
Basomedial | #(81) | ✓(82) | — | n/a | n/a | n/a |
Medial | #(83) | ✓(84) | #(85) | n/a | n/a | n/a |
VGAT (PFC) | ||||||
IL+PrL | #(86) | #(87) | ✓(88) | — | ↑* | — |
Cg1+Cg2 | — | ✓(89) | — | n/a | n/a | n/a |
E/I Balance (Fig. 7) | ||||||
Amygdala | ||||||
Central | — | — | — | n/a | n/a | n/a |
Lateral | #(90) | ✓(91) | — | n/a | n/a | n/a |
Basolateral | — | ✓(92) | — | n/a | n/a | n/a |
Basomedial | — | — | — | n/a | n/a | n/a |
Medial | — | — | — | n/a | n/a | n/a |
PFC | ||||||
IL+PrL | #(93) | ✓(94) | ✓(95) | — | — | ↑* |
Cg1+Cg2 | ✓(96) | ✓(97) | — | n/a | n/a | n/a |
↵Symbols: (✓) statistically significant effect (two-way ANOVA); (-) no statistically significant effect (two-way ANOVA) or difference from NaCl-Social group (post hoc); (↑) increase; (n/a) not applicable; (↓) decrease; *p < 0.05; **p < 0.01; ***p < 0.001; #0.10 ≥ p ≥ 0.05.
F and p values: (64) F(1,29) = 4.58, p = 0.041; (65) F(1,29) = 7.12, p = 0.012; (66) F(1,29) = 4.20, p = 0.049; (67) F(1,28) = 4.89, p = 0.036; (68) F(1,28) = 6.08, p = 0.020; (69) F(1,28) = 3.17, p = 0.086; (70) F(1,29) = 3.74, p = 0.063; (71) F(1,29) = 4.32, p = 0.047; (72) F(1,29) = 5.01, p = 0.033; (73) F(1,19) = 6.31, p = 0.021; (74) F(1,19) = 8.44, p = 0.009; (75) F(1,19) = 3.54, p = 0.075; (76) F(1,29) = 3.45, p = 0.074; (77) F(1,28) = 5.28, p = 0.029; (78) F(1,29) = 3.09, p = 0.089; (79) F(1,29) = 3.88, p = 0.058; (80) F(1,29) = 2.91, p = 0.097; (81) F(1,29) = 3.16, p = 0.086; (82) F(1,29) = 4.29, p = 0.047; (83) F(1,29) = 3.47, p = 0.073; (84) F(1,29) = 5.88, p = 0.022; (85) F(1,29) = 3.05, p = 0.091; (86) F(1,18) = 3.75, p = 0.069; (87) F(1,18) = 3.88, p = 0.065; (88) F(1,18) = 6.53, p = 0.020; (89) F(1,19) = 21.12, p = 2 × 10−4; (90) F(1,29) = 3.55, p = 0.070; (91) F(1,29) = 9.01, p = 0.005; (92) F(1,28) = 6.75, p = 0.015; (93) F(1,18) = 3.93, p = 0.063; (94) F(1,18) = 6.18, p = 0.023; (95) F(1,18) = 6.39, p = 0.021; (96) F(1,18) = 10.72, p = 0.004; (97) F(1,18) = 8.33, p = 0.0098.