Parameter | Main effects (two-way ANOVA) | Group differences (from NaCl-Social) | ||||
---|---|---|---|---|---|---|

Treatment | Rearing | Interaction | NaCl-Isolation | MK801-Social | MK801-Isolation | |

Structure of pyramidal neurons (Fig. 5) | ||||||

Dendritic spines | ||||||

PFC | ||||||

50 | — | — | ✓^{(28)} | — | — | — |

100 | — | — | — | n/a | n/a | n/a |

150 | — | ✓^{(29)} | — | n/a | n/a | n/a |

200 | ✓^{(30)} | — | — | n/a | n/a | n/a |

Total | — | — | — | n/a | n/a | n/a |

Structure of interneurons (Fig. 6) | ||||||

Dendritic arborization | ||||||

Amygdala | ||||||

20 | — | ^{#}^{(31)} | ✓^{(32)} | — | — | — |

40 | — | ✓^{(33)} | ✓^{(34)} | — | — | ↑^{*} |

60 | ✓^{(35)} | ✓^{(36)} | ✓^{(37)} | — | — | ↑^{***} |

80 | ✓^{(38)} | ✓^{(39)} | ✓^{(40)} | — | — | ↑^{*} |

100 | ✓^{(41)} | ✓^{(42)} | ^{#}^{(43)} | n/a | n/a | n/a |

120 | ✓^{(44)} | ✓^{(45)} | ✓^{(46)} | — | — | ↑^{*} |

140 | ^{#}^{(47)} | — | — | n/a | n/a | n/a |

160 | — | — | — | n/a | n/a | n/a |

Total | ✓^{(48)} | ✓^{(49)} | ✓^{(50)} | — | — | ↑^{***} |

PFC | ||||||

20 | — | — | — | n/a | n/a | n/a |

40 | — | — | — | n/a | n/a | n/a |

60 | — | — | — | n/a | n/a | n/a |

80 | — | — | — | n/a | n/a | n/a |

100 | — | — | — | n/a | n/a | n/a |

120 | — | — | — | n/a | n/a | n/a |

140 | — | — | — | n/a | n/a | n/a |

160 | — | — | — | n/a | n/a | n/a |

Total | — | — | — | n/a | n/a | n/a |

Dendritic spines | ||||||

Amygdala | ||||||

50 | — | — | — | n/a | n/a | n/a |

100 | — | — | — | n/a | n/a | n/a |

150 | — | ^{#}^{(51)} | ^{#}^{(52)} | n/a | n/a | n/a |

Total | — | — | — | n/a | n/a | n/a |

PFC | ||||||

50 | ^{#}^{(53)} | ✓^{(54)} | ^{#}^{(55)} | n/a | n/a | n/a |

100 | ✓^{(56)} | ✓^{(57)} | ✓^{(58)} | ↑^{*} | ↑^{**} | ↑^{**} |

150 | ✓^{(59)} | ✓^{(60)} | — | n/a | n/a | n/a |

Total | ✓^{(61)} | ✓^{(62)} | ✓^{(63)} | ↑^{**} | ↑^{***} | ↑^{***} |

↵Symbols: (✓) statistically significant effect (two-way ANOVA); (—) no statistically significant effect (two-way ANOVA) or difference from NaCl-Social group (

*post hoc*); (↑) increase; (n/a) not applicable; (↓) decrease; **p*< 0.05; ***p*< 0.01; ****p*< 0.001; #0.10 ≥*p*≥ 0.05.*F*and*p*values: (28)*F*_{(1,15)}= 6.29,*p*= 0.024; (29)*F*_{(1,15)}= 4.88,*p*= 0.043; (30)*F*_{(1,18)}= 4.90,*p*= 0.043 (31)*F*_{(1,19)}= 3.81,*p*= 0.066; (32)*F*_{(1,19)}= 4.72,*p*= 0.043; (33)*F*_{(1,19)}= 9.02,*p*= 0.007; (34)*F*_{(1,19)}= 12.58,*p*= 0.002; (35)*F*_{(1,18)}= 7.53,*p*= 0.013; (36)*F*_{(1,18)}= 23.53,*p*= 12.8 × 10^{−5}; (37)*F*_{(1,18)}= 12.62,*p*= 0.002; (38)*F*_{(1,19)}= 4.64,*p*= 0.044; (39)*F*_{(1,19)}= 6.55,*p*= 0.019; (40)*F*_{(1,19)}= 10.23,*p*= 0.005; (41)*F*_{(1,20)}= 4.43,*p*= 0.048; (42)*F*_{(1,20)}= 8.79,*p*= 0.008; (43)*F*_{(1,20)}= 3.27,*p*= 0.086; (44)*F*_{(1,20)}= 5.73,*p*= 0.027; (45)*F*_{(1,20)}= 5.32,*p*= 0.032; (46)*F*_{(1,20)}= 14.63,*p*= 0.0011; (47)*F*_{(1,20)}= 4.34,*p*= 0.050; (48)*F*_{(1,20)}= 8.31,*p*= 0.009; (49)*F*_{(1,20)}= 14.29,*p*= 0.001; (50)*F*_{(1,20)}= 18.23,*p*= 37.5 × 10^{−5}; (51)*F*_{(1,22)}= 3.79,*p*= 0.064; (52)*F*_{(1,22)}= 3.34,*p*= 0.081; (53)*F*_{(1,22)}= 3.74,*p*= 0.066; (54)*F*_{(1,22)}= 4.53,*p*= 0.045; (55)*F*_{(1,22)}= 3.31,*p*= 0.083; (56)*F*_{(1,22)}= 11.72,*p*= 0.002; (57)*F*_{(1,22)}= 5.50,*p*= 0.029; (58)*F*_{(1,22)}= 5.18,*p*= 0.033; (59)*F*_{(1,22)}= 5.50,*p*= 0.028; (60)*F*_{(1,22)}= 7.43,*p*= 0.012; (61)*F*_{(1,22)}= 21.08,*p*= 14.2 × 10^{−5}; (62)*F*_{(1,22)}= 6.27,*p*= 0.020; (63)*F*_{(1,22)}= 10.18,*p*= 0.004.