Parameter | Main effects (two-way ANOVA) | Group differences (from NaCl-Social) | ||||
---|---|---|---|---|---|---|
Treatment | Rearing | Interaction | NaCl-Isolation | MK801-Social | MK801-Isolation | |
Protein expression (Fig.7) | ||||||
GAD67 | ||||||
Amygdala | — | ✓(98) | — | n/a | n/a | n/a |
PFC | — | — | — | n/a | n/a | n/a |
SYN | ||||||
Amygdala | — | — | — | n/a | n/a | n/a |
PFC | — | — | — | n/a | n/a | n/a |
PSA-NCAM | ||||||
Amygdala | ✓(99) | ✓(100) | #(101) | n/a | n/a | n/a |
PFC | ✓(102) | — | — | n/a | n/a | n/a |
Gene expression (Fig.7) | ||||||
GAD67 | ||||||
Amygdala | — | — | — | n/a | n/a | n/a |
PFC | #(103) | — | — | n/a | n/a | n/a |
BDNF | ||||||
Amygdala | — | — | — | n/a | n/a | n/a |
PFC | — | ✓(104) | — | n/a | n/a | n/a |
ErbB4 | ||||||
Amygdala | — | — | #(105) | n/a | n/a | n/a |
PFC | — | — | — | n/a | n/a | n/a |
CB1-R | ||||||
Amygdala | — | ✓(106) | — | n/a | n/a | n/a |
PFC | — | — | — | n/a | n/a | n/a |
ST8SiaII | ||||||
Amygdala | #(107) | — | — | n/a | n/a | n/a |
PFC | — | — | — | n/a | n/a | n/a |
ST8SiaIV | ||||||
Amygdala | — | — | — | n/a | n/a | n/a |
PFC | #(108) | ✓(109) | — | n/a | n/a | n/a |
↵Symbols: (✓) statistically significant effect (two-way ANOVA); (—) no statistically significant effect (two-way ANOVA) or difference from NaCl-Social group (post hoc); (↑) increase; (n/a) not applicable; (↓) decrease; (*) p < 0.05; (**) p < 0.01; (***) p < 0.001; (#) 0.10 ≥ p ≥ 0.05.
F and p values: (98) F(1,19) = 11.74, p = 0.003; (99) F(1,25) = 11.58, p = 0.002; (100) F(1,25) = 107.23, p < 10−10; (101) F(1,25) = 4.02, p = 0.056; (102) F(1,32) = 9.863, p = 0.004; (103) F(1,25) = 3.94, p = 0.058; (104) F(1,26) = 13.51, p = 0.001; (105) F(1,25) = 4.10, p = 0.054; (106) F(1,26) = 5.52, p = 0.027; (107) F(1,20) = 3.07, p = 0.095; (108) F(1,25) = 4.12, p = 0.053; (109) F(1,25) = 5.06, p = 0.033.