Summary of the pathologic findings of PQD1 and 2
| PQD1 | PQD2 | |||
|---|---|---|---|---|
| 13.5 months | 5.5 months | |||
| Degeneration | Inclusion | Degeneration | Inclusion | |
| Cerebrum | − | − | − | + |
| Cerebellum | ++ | − | − | − |
| Brain stem | − | ± | − | + |
| Spinal cord | ++ | ++ | ++ | ++ |
| Peripheral nerves | ++ | N/E | ++ | N/E |
| Skeletal muscles | +++ | ++ | +++ | ++ |
Two marmosets among the three symptomatic transgenic marmosets were subjected to immunohistochemical analysis. Note that cerebellar degeneration was observed in PQD1. N/E: not examined.