1*D* | Quantification of DNA by qPCR (*n* = 4–6, 2 biological replicates with each having 2–3 technical replicates) | One-way ANOVA followed by Student’s *t* test (two-tailed, type 2) | **p* < 0.05, ***p* < 1 × 10^{−4} |

3*A* | Quantification of DNA by qPCR (*n* = 18, 6 biological replicates with each having 3 technical replicates) | One-way ANOVA followed by Student’s *t* test (two-tailed, type 2) | **p* < 0.05, ***p* < 1 × 10^{−4}, ****p* < 1 × 10^{−5} |

3*B* | Measurement of luciferase reporter activity (*n* = 9, 3 biological replicates with each having 3 technical replicates) | Gaussian distribution was confirmed by D’Agostino–Pearson normality test (α = 0.05); one-way ANOVA followed by *post hoc* Tukey’s test | *****p* < 0.0001 |

4*B* | Quantification of mRNA by RT-qPCR (*n* = 9, 3 biological replicates, with each having 3 technical replicates) | Gaussian distribution was confirmed by D’Agostino–Pearson normality test (α = 0.05); one-way ANOVA followed by *post hoc* Tukey’s test | **p* = 0.023 |

4*D* | Quantification of protein levels by immunoblotting (*n* = 3 biological replicates) | Unpaired *t* test (two-tailed, type 2) | *p* = 0.057 |

4*G*,*H* | Quantification of protein levels by immunofluorescence (*n* = 30, from 2 biological replicates) | Nonparametric Kruskal–Wallis test followed by Dunn’s multiple-correction analysis | **p* < 0.02,***p* = 0.0012, *****p* < 0.0001 |

6*B–F* | Quantification of calcium levels by measuring Fluo-3 signal (*n* = 20–50 per condition) | Nonparametric Kruskal–Wallis test followed by Dunn’s multiple-correction analysis | ***p* = 0.0073, ****p* = 0.0008 |

7*B–F* | Quantification of calcium levels by measuring Fluo-3 signal (*n* = 20–40 per condition) | Unpaired *t* test (two-tailed, type 2) | **p* < 0.05 |