Table 2.

Static intrinsic properties of MVN neurons.

Alltype Atype BStatistical tests (Mann–Whitney)
PropertyControlVVMControlVVMControlVVMControl vs. VVM
Number of neurons636027173643Alltype Atype B
Membrane potential (mV)–48.28–49.00–47.24–47.22–49.07–49.70z = –1.09NSz = –0.02NSz = –0.81NS
Spike threshold (mV)–31.32–32.34–29.58–30.73–32.63–32.97z = –1.36NSz = –0.99NSz = –0.39NS
Firing rate (Hz)12.247.8513.838.1411.047.74z = –2.49p = 0.013z = –1.73p = 0.08z = –1.57NS
Coefficient of variation0. = 1.97p = 0.048z = 1.40NSz = 1.11NS
AHPR (V/s) = –1.29NSz = –0.09NSz = –0.11NS
dAHP (V/s)0.710.690. = –0.07NSNANAz = –1.14NS
AHP (mV)26.1125.2529.6828.5423.4323.95z = –0.16NSz = –0.14NSz = 0.48NS
Concavity (mV)–1.33–1.50–2.49–3.47–0.46–0.73z = 0.002NSz = –1.49NSz = –0.59NS
Convexity (mV)0.820.840.560.341.021.05z = 0.13NSz = –0.98NSz = 0.03NS
  • Parameters of the spontaneous activity of MVN neurons recorded on control and VVM slices. Static parameters are based on the analysis of the pacemaker discharge of the neurons and the quantification of the AHP and interspike interval. Neurons are pooled (all) or segmented in type A and type B. Overall, the intrinsic membrane properties recorded in controls and VVM mice show limited differences between type A and type B neurons. AHPR, dAHP, and AHP are parameters representing kinetics of the AHP and interspike interval (see Materials and methods). Statistically significant differences are highlighted in red. NS, not significant.