Table 1.

Recent literature examining C-bouton size in ALS mouse models

1. Authors2. Age3. Change4. Magnitude of change5. Calculated effect size6. Grouping unit7. Blinding8. Power analysis9. Size parameter10. Sex/no. of animals (WT, G93A)
Pullen and Athanasiou (2009)P42P70P156NCIncreaseIncreaseN/A25%56%N/A0.711.42By boutonNot reportedNot reportedAppositional lengthM2
Herron and Miles (2012)P8P30P120P140NCIncreaseIncreaseIncreaseN/A7%14%17%Inadequate information1ByanimalBlindingincludedNot reportedAppositional length (Feret’s diameter)M (25 mice total for all time points and groups)3
Saxena et al. (2013)P37Increase100%Inadequate information1By boutonNot reportedNot reportedVolumeM (3, 3)
Milan et al. (2015)P10P21P40P75P100DecreaseIncreaseNCNCDecrease9%7%N/AN/A5%0.150.17N/AN/A0.43BycellBlindingincludedNot reportedAreaM (6, 6)M (7, 6)M (8, 6)M (6, 7)M (5, 8)
This articleP10P30P90P120+NCNCNCNCN/AN/AN/AN/AN/ABycellBlindingincludedIncludedLargest cross-sectional areaM (3, 3)M (4, 4)M (3, 3)M (3, 3)
  • 1, Authors; 2, age of G93A mouse studied; 3, whether C-bouton size increases, decreases, or there was no change were reported for each age studied; 4, magnitude of change; 5, calculated effect size, if possible; 6, the sampling strategy (grouping unit) used; 7, the reported blinding status, if reported; and 8, the power analysis, if reported. M, Male; N/A, not available; NC, no change.

  • 1Inadequate information. SD values or sample size (n) data were not included in the published work, making the calculation of effect size impossible.

  • 2No information on animal number was provided.

  • 3Information on each time point was not provided. Female data not included in the table comparison.