Molecular matching among 436 disease signatures and the juvenile plasticity signature indicates diverse diseases may disrupt plasticity
Rank | Normalized molecular match score | Emp_pval | FDR | Source_dat | Species | Disease | Tissue |
---|---|---|---|---|---|---|---|
1 | 9.64 | 4.53E-08 | 1.22E-05 | GSE7958 | Mus musculus | Huntington's disease | CNS, brain, striatum (MMHCC) |
2 | 8.35 | 7.74E-08 | 1.22E-05 | GSE1623 | Mus musculus | Type 1 diabetes mellitus | Pancreas |
3 | 8.32 | 8.58E-07 | 3.40E-05 | GSE9857 | Mus musculus | Huntington's disease | CNS, brain, striatum (MMHCC) |
4 | 7.96 | 1.38E-07 | 1.22E-05 | GSE4648 | Mus musculus | Acute myocardial infarction | Myocardial tissue |
5 | 7.59 | 1.40E-07 | 1.22E-05 | GSE4290 | Homo sapiens | Glioblastoma | CNS, brain (MMHCC) |
6 | 7.52 | 3.36E-07 | 2.44E-05 | GSE1481 | Homo sapiens | Anterior horn cell disease | CNS, spinal cord (MMHCC) |
7 | 6.81 | 9.04E-08 | 1.22E-05 | GSE2240 | Homo sapiens | Atrial fibrillation | Myocardial tissue |
8 | 6.73 | 1.47E-06 | 4.94E-05 | GSE5500 | Mus musculus | Cardiac hypertrophy | Myocardial tissue |
9 | 6.47 | 8.10E-07 | 3.40E-05 | GSE5389 | Homo sapiens | Bipolar disorder | frontal cortex |
10 | 6.33 | 8.15E-07 | 3.40E-05 | GSE5078 | Mus musculus | Senescence | Hippocampus |
11 | 6.25 | 1.75E-06 | 5.46E-05 | GSE4764 | Mus musculus | Yersinia enterocolitica food poisoning | Peyer's patch |
12 | 5.75 | 7.82E-07 | 3.40E-05 | GSE4290 | Homo sapiens | Astrocytoma | CNS, brain (MMHCC) |
13 | 5.7 | 1.73E-05 | 3.59E-04 | GSE1621 | Mus musculus | Cardiac hypertrophy | Myocardial tissue |
14 | 5.67 | 6.55E-05 | 7.88E-04 | GSE3253 | Mus musculus | Bacterial infection | CNS, brain (MMHCC) |
15 | 5.61 | 1.16E-06 | 4.22E-05 | GSE10599 | Mus musculus | Spinal muscular atrophy | Kidney |
16 | 5.55 | 2.49E-06 | 7.25E-05 | GSE3744 | Homo sapiens | Breast cancer | Mammary gland tissue |
17 | 5.43 | 1.32E-05 | 3.04E-04 | GSE6731 | Homo sapiens | Crohn's disease | Intestine, large intestine, colon (MMHCC) |
18 | 5.38 | 2.24E-05 | 4.24E-04 | GSE6731 | Homo sapiens | Ulcerative colitis | Intestine, large intestine, colon (MMHCC) |
19 | 5.35 | 1.29E-05 | 3.04E-04 | GSE11343 | Mus musculus | Diabetic neuropathy | Sciatic nerve |
20 | 5.35 | 7.33E-07 | 3.40E-05 | GSE4316 | Homo sapiens | Primary open angle glaucoma | Trabecular meshwork |
21 | 5.28 | 2.67E-05 | 4.65E-04 | GSE5406 | Homo sapiens | Cardiomyopathy | Myocardial tissue |
22 | 5.02 | 3.36E-05 | 5.29E-04 | GSE464 | Rattus norvegicus | Spinal cord injury | CNS, spinal cord (MMHCC) |
23 | 4.98 | 1.87E-05 | 3.71E-04 | EXPE-MEXP-567 | Homo sapiens | Glioblastoma | Brain |
24 | 4.94 | 1.17E-04 | 1.13E-03 | GSE1025 | Mus musculus | DMD | Muscle, striated (skeletal) (MMHCC) |
25 | 4.9 | 5.26E-05 | 6.95E-04 | GSE1843 | Rattus norvegicus | Hepatic cirrhosis | Hepatic tissue |
26 | 4.86 | 1.54E-05 | 3.37E-04 | GSE1572 | Homo sapiens | Senescence | frontal cortex |
27 | 4.81 | 6.87E-05 | 7.88E-04 | GSE1472 | Mus musculus | DMD | Muscle, striated (skeletal) (MMHCC) |
28 | 4.81 | 9.47E-06 | 2.43E-04 | GSE2510 | Homo sapiens | Obesity | Adipocyte |
29 | 4.8 | 3.91E-05 | 5.49E-04 | GSE3383 | Mus musculus | Cardiac hypertrophy | Myocardial tissue |
30 | 4.78 | 1.06E-04 | 1.05E-03 | GSE1629 | Homo sapiens | Dental cavity, complex | Dental pulp |
31 | 4.72 | 6.79E-05 | 7.88E-04 | GSE2629 | Mus musculus | Muscular dystrophy | Muscle, striated (skeletal) (MMHCC) |
32 | 4.67 | 3.90E-05 | 5.49E-04 | GSE4290 | Homo sapiens | Oligodendroglioma | CNS, brain (MMHCC) |
33 | 4.63 | 1.71E-04 | 1.49E-03 | GSE10760 | Homo sapiens | Muscular dystrophy | Musculus vastus lateralis |
34 | 4.62 | 9.53E-05 | 1.01E-03 | GSE1988 | Mus musculus | Cardiac failure | Myocardial tissue |
35 | 4.61 | 4.84E-05 | 6.59E-04 | GSE3467 | Homo sapiens | Papillary carcinoma of the thyroid | Thyroid gland (MMHCC) |
36 | 4.57 | 3.84E-05 | 5.49E-04 | GSE3621 | Mus musculus | Huntington's disease | Brain |
37 | 4.56 | 3.35E-05 | 5.29E-04 | GSE4107 | Homo sapiens | Cancer of colon | Intestine, large intestine, colon (MMHCC) |
38 | 4.54 | 1.20E-04 | 1.14E-03 | GSE842 | Mus musculus | MS | CNS, spinal cord (MMHCC) |
39 | 4.53 | 8.18E-05 | 9.14E-04 | GSE14905 | Homo sapiens | Psoriasis vulgaris | Skin tissue |
40 | 4.51 | 3.40E-05 | 5.29E-04 | GSE7305 | Homo sapiens | Endometriosis | Endometrium |
41 | 4.48 | 8.91E-06 | 2.43E-04 | GSE16524 | Homo sapiens | Setleis syndrome | Skin fibroblast |
42 | 4.46 | 6.85E-05 | 7.88E-04 | GSE4183 | Homo sapiens | Carcinoma in situ of large intestine | Colon |
43 | 4.43 | 2.37E-05 | 4.30E-04 | GSE12654 | Homo sapiens | Schizophrenia | Cerebral cortex |
44 | 4.3 | 1.62E-04 | 1.44E-03 | GSE2866 | Mus musculus | γ-Hydroxybutyric acidemia | CNS, brain, cerebellum (MMHCC) |
45 | 4.22 | 9.23E-05 | 1.01E-03 | GSE1859 | Mus musculus | FDIU | Hepatic tissue |
46 | 4.19 | 5.52E-05 | 7.08E-04 | GSE4587 | Homo sapiens | Malignant melanoma | Epidermis |
47 | 4.16 | 2.13E-04 | 1.82E-03 | GSE63 | Mus musculus | Cerebral infarction | CNS, brain (MMHCC) |
48 | 4.16 | 2.26E-04 | 1.83E-03 | GSE6614 | Mus musculus | Generalized seizures | Brain |
49 | 4.08 | 1.58E-04 | 1.44E-03 | GSE6280 | Homo sapiens | Chronic kidney disease | Kidney |
50 | 4.01 | 3.19E-04 | 2.44E-03 | GSE5390 | Homo sapiens | Down’s syndrome | Brain |
51 | 4.01 | 2.66E-04 | 2.11E-03 | GSE2052 | Homo sapiens | Idiopathic fibrosing alveolitis | Lung tissue |
52 | 4 | 2.23E-04 | 1.83E-03 | GSE1873 | Mus musculus | Obstructive sleep apnea | Hepatic tissue |
53 | 3.97 | 4.39E-04 | 3.07E-03 | GSE4183 | Homo sapiens | IBD | Colon |
54 | 3.96 | 1.01E-04 | 1.02E-03 | GSE3075 | Mus musculus | Spinal muscular atrophy, infantile | CNS, spinal cord (MMHCC) |
55 | 3.94 | 1.42E-04 | 1.32E-03 | GSE3167 | Homo sapiens | Urothelial carcinoma in situ | Urothelium |
56 | 3.93 | 2.20E-04 | 1.83E-03 | GSE8514 | Homo sapiens | Adenoma | Adrenal gland |
57 | 3.93 | 4.01E-04 | 2.92E-03 | GSE6764 | Homo sapiens | Carcinoma, hepatocellular | Liver |
58 | 3.92 | 4.89E-04 | 3.18E-03 | GSE3585 | Homo sapiens | Cardiomyopathy, dilated | Myocardial tissue |
59 | 3.89 | 3.39E-04 | 2.55E-03 | GSE1420 | Homo sapiens | Barrett esophagus | Esophageal tissue |
60 | 3.88 | 9.89E-05 | 1.02E-03 | GSE1420 | Homo sapiens | Adenocarcinoma of esophagus | Esophageal tissue |
61 | 3.87 | 4.40E-04 | 3.07E-03 | GSE781 | Homo sapiens | Clear cell carcinoma of kidney | Renal tissue |
62 | 3.87 | 5.95E-04 | 3.51E-03 | GSE2528 | Mus musculus | Breast cancer | Mammary gland |
63 | 3.84 | 9.37E-04 | 4.92E-03 | GSE1026 | Mus musculus | DMD | Muscle, striated (skeletal), diaphragm (MMHCC) |
64 | 3.79 | 5.25E-04 | 3.35E-03 | GSE3678 | Homo sapiens | Papillary carcinoma of the thyroid | Thyroid gland (MMHCC) |
65 | 3.74 | 4.88E-04 | 3.18E-03 | GSE4619 | Homo sapiens | MDS | Bone marrow stem cell |
66 | 3.73 | 5.92E-04 | 3.51E-03 | GSE3112 | Homo sapiens | Polymyositis | Muscle tissue |
67 | 3.72 | 3.51E-04 | 2.59E-03 | GSE3189 | Homo sapiens | Multiple benign melanocytic nevi | Epidermis |
68 | 3.68 | 5.76E-04 | 3.49E-03 | GSE769 | Mus musculus | Cystic fibrosis | Pancreas |
69 | 3.66 | 5.76E-04 | 3.49E-03 | GSE10432 | Homo sapiens | Acne | Sebocyte |
70 | 3.65 | 1.30E-03 | 6.16E-03 | GSE3252 | Mus musculus | Muscular dystrophy | Muscle, striated (skeletal), diaphragm (MMHCC) |
71 | 3.62 | 4.81E-04 | 3.18E-03 | GSE12649 | Homo sapiens | Schizophrenia | Cerebral cortex |
72 | 3.6 | 7.41E-04 | 4.17E-03 | GSE2501 | Mus musculus | Thymic carcinoma | Thymus |
73 | 3.59 | 1.20E-03 | 5.87E-03 | GSE3268 | Homo sapiens | Squamous cell carcinoma of lung | Lung tissue |
74 | 3.58 | 7.82E-04 | 4.32E-03 | GSE857 | Mus musculus | Huntington's disease | CNS, brain (MMHCC) |
75 | 3.58 | 2.96E-04 | 2.30E-03 | GSE1009 | Homo sapiens | Diabetic nephropathy | Renal tissue |
76 | 3.57 | 1.20E-03 | 5.87E-03 | GSE977 | Mus musculus | Alexander disease | CNS, brain, olfactory bulb (MMHCC) |
77 | 3.55 | 5.37E-04 | 3.35E-03 | GSE2826 | Mus musculus | Bruton's agammaglobulinemia | B-cell lymphocyte |
78 | 3.54 | 7.46E-04 | 4.17E-03 | GSE2640 | Mus musculus | Pulmonary fibrosis | Lung tissue |
79 | 3.53 | 5.37E-04 | 3.35E-03 | GSE2514 | Homo sapiens | Adenocarcinoma of lung | Lung tissue |
80 | 3.53 | 8.90E-04 | 4.73E-03 | GSE1551 | Homo sapiens | Dermatomyositis | Muscle, striated (skeletal) (MMHCC) |
81 | 3.52 | 4.50E-04 | 3.07E-03 | GSE2507 | Mus musculus | Muscular dystrophy | Muscle, striated (skeletal) (MMHCC) |
82 | 3.5 | 7.15E-04 | 4.10E-03 | GSE3189 | Homo sapiens | Malignant melanoma | Epidermis |
83 | 3.5 | 1.10E-03 | 5.58E-03 | GSE4764 | Mus musculus | Y. enterocolitica food poisoning | Lymph node |
84 | 3.45 | 8.68E-04 | 4.67E-03 | EXPE-MEXP-567 | Homo sapiens | Glioblastoma | Brain |
85 | 3.43 | 4.44E-04 | 3.07E-03 | GSE3408 | Homo sapiens | Atypical mycobacterial infection | macrophage |
86 | 3.43 | 1.10E-03 | 5.58E-03 | GSE6428 | Rattus norvegicus | Type 2 diabetes mellitus | Endocrine pancreas, islet cell of Langerhans, β-cell (MMHCC) |
87 | 3.42 | 8.45E-04 | 4.61E-03 | GSE10575 | Homo sapiens | Arthropathy | Chondrocyte |
88 | 3.4 | 6.73E-04 | 3.91E-03 | GSE9375 | Mus musculus | Huntington's disease | CNS, brain, striatum (MMHCC) |
89 | 3.39 | 2.10E-03 | 9.16E-03 | GSE4390 | Mus musculus | ALS | CNS, spinal cord (MMHCC) |
90 | 3.38 | 1.21E-03 | 5.87E-03 | GSE3644 | Mus musculus | Acute pancreatitis | Pancreas |
91 | 3.38 | 1.30E-03 | 6.16E-03 | GSE3112 | Homo sapiens | Inclusion body myositides | Muscle tissue |
92 | 3.33 | 1.10E-03 | 5.58E-03 | GSE466 | Mus musculus | DMD | Muscle, striated (skeletal) (MMHCC) |
93 | 3.29 | 1.40E-03 | 6.36E-03 | GSE2144 | Homo sapiens | GERD | Esophageal tissue |
94 | 3.27 | 1.40E-03 | 6.36E-03 | EXPE-MEXP-1296 | Mus musculus | Cancer of prostate | Prostate |
95 | 3.24 | 1.70E-03 | 7.64E-03 | GSE2724 | Homo sapiens | Uterine leiomyoma | Uterus |
96 | 3.21 | 3.30E-03 | 1.30E-02 | GSE2825 | Rattus norvegicus | Idiosyncratic drug effect | Hepatic tissue |
97 | 3.19 | 2.60E-03 | 1.08E-02 | GSE1007 | Homo sapiens | DMD | Muscle, striated (skeletal) (MMHCC) |
98 | 3.19 | 1.20E-03 | 5.87E-03 | GSE1781 | Rattus norvegicus | Sepsis | Hepatic tissue |
99 | 3.18 | 2.40E-03 | 1.03E-02 | GSE2899 | Mus musculus | Type 2 diabetes mellitus | Adipose tissue |
100 | 3.18 | 1.90E-03 | 8.37E-03 | GSE2557 | Mus musculus | Kidney disorder associated with type 2 diabetes mellitus | Mesangial cell |
101 | 3.18 | 1.40E-03 | 6.36E-03 | GSE3524 | Homo sapiens | Squamous cell carcinoma of mouth | Oropharynx epithelium |
102 | 3.17 | 1.40E-03 | 6.36E-03 | GSE13355 | Homo sapiens | Psoriasis vulgaris | Skin tissue |
103 | 3.15 | 2.20E-03 | 9.50E-03 | GSE2866 | Mus musculus | γ-Hydroxybutyric acidemia | Cerebral cortex |
104 | 3.12 | 2.60E-03 | 1.08E-02 | GSE4911 | Mus musculus | Cleidocranial dysostosis | Humerus |
105 | 3.12 | 1.90E-03 | 8.37E-03 | GSE24807 | Homo sapiens | NASH | Liver |
106 | 3.12 | 3.20E-03 | 1.28E-02 | GSE10631 | Homo sapiens | LGLL | Peripheral blood mononuclear cell |
107 | 3.11 | 2.70E-03 | 1.11E-02 | GSE2052 | Homo sapiens | Scleroderma | Lung tissue |
108 | 3.07 | 2.90E-03 | 1.17E-02 | GSE4692 | Mus musculus | Obesity | Adipose tissue |
109 | 3.05 | 2.50E-03 | 1.06E-02 | GSE4824 | Homo sapiens | Non-small cell lung cancer | Bronchial epithelium |
110 | 3.03 | 3.80E-03 | 1.47E-02 | GSE1145 | Homo sapiens | Ischemic cardiomyopathy | Myocardial tissue |
111 | 3.01 | 4.90E-03 | 1.77E-02 | GSE6678 | Mus musculus | Infantile neuronal ceroid lipofuscinosis | Brain |
112 | 3 | 3.30E-03 | 1.30E-02 | GSE3064 | Homo sapiens | Dystonia | Brain |
113 | 2.99 | 4.70E-03 | 1.72E-02 | GSE2527 | Mus musculus | Thrombocytopenia | Megakaryocyte |
114 | 2.99 | 4.30E-03 | 1.62E-02 | GSE2433 | Mus musculus | Leukemia, acute megakaryocytic | Megakaryocyte |
115 | 2.93 | 4.60E-03 | 1.71E-02 | GSE1776 | Mus musculus | Nutritional deficiency, NEC | Skeletal myocyte |
116 | 2.93 | 3.90E-03 | 1.49E-02 | GSE4587 | Homo sapiens | In situ melanoma of skin | Epidermis |
117 | 2.92 | 5.30E-03 | 1.88E-02 | GSE9579 | Homo sapiens | Appendicitis | Appendix |
118 | 2.91 | 5.80E-03 | 2.01E-02 | GSE2411 | Mus musculus | Ventilator-associated lung injury | Lung tissue |
119 | 2.9 | 2.80E-03 | 1.14E-02 | GSE1037 | Homo sapiens | Small cell carcinoma of lung | Lung tissue |
120 | 2.86 | 5.20E-03 | 1.86E-02 | GSE2401 | Rattus norvegicus | Hypotensive episode | Renal tissue |
121 | 2.85 | 4.70E-03 | 1.72E-02 | GSE765 | Mus musculus | Cystic fibrosis | Intestinal epithelium |
122 | 2.83 | 3.60E-03 | 1.40E-02 | EXPE-MEXP-882 | Homo sapiens | Invasive ductal breast cancer | Mammary epithelium |
123 | 2.83 | 6.70E-03 | 2.28E-02 | GSE1869 | Homo sapiens | Ischemic cardiomyopathy | Myocardial tissue |
124 | 2.82 | 5.60E-03 | 1.95E-02 | GSE4183 | Homo sapiens | Adenoma | Colon |
125 | 2.82 | 5.40E-03 | 1.90E-02 | GSE1004 | Homo sapiens | DMD | Muscle, striated (skeletal) (MMHCC) |
126 | 2.81 | 4.30E-03 | 1.62E-02 | GSE9944 | Homo sapiens | Glaucoma | Astrocyte |
127 | 2.79 | 6.20E-03 | 2.13E-02 | EXPE-TABM-176 | Homo sapiens | Irritable bowel syndrome variant of childhood with diarrhea | Sigmoid colon |
128 | 2.72 | 8.40E-03 | 2.75E-02 | GSE2779 | Homo sapiens | MDS | Bone marrow stem cell |
129 | 2.72 | 7.20E-03 | 2.43E-02 | GSE1947 | Mus musculus | Peripheral motor neuropathy | Sciatic nerve |
130 | 2.71 | 8.40E-03 | 2.75E-02 | GSE593 | Homo sapiens | Uterine leiomyoma | Uterus, myometrium (MMHCC) |
131 | 2.71 | 7.50E-03 | 2.52E-02 | GSE2712 | Homo sapiens | Clear cell sarcoma of kidney | Renal tissue |
132 | 2.69 | 8.50E-03 | 2.75E-02 | GSE1459 | Mus musculus | Bacterial Infection | Macrophage |
133 | 2.67 | 8.50E-03 | 2.75E-02 | GSE1811 | Mus musculus | Occupational lung disease | Lung Tissue |
134 | 2.67 | 8.90E-03 | 2.85E-02 | GSE2508 | Homo sapiens | Obesity | Adipocyte |
135 | 2.66 | 8.10E-03 | 2.70E-02 | GSE1462 | Homo sapiens | MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) | Muscle, striated (skeletal) (MMHCC) |
136 | 2.65 | 9.00E-03 | 2.86E-02 | GSE4130 | Rattus norvegicus | Dehydration | CNS, brain, hypothalamus (MMHCC) |
137 | 2.61 | 9.10E-03 | 2.88E-02 | GSE1378 | Homo sapiens | Breast cancer | Mammary gland tissue |
138 | 2.6 | 1.14E-02 | 3.45E-02 | GSE1375 | Mus musculus | Alzheimer's disease | Cerebral cortex |
139 | 2.59 | 9.80E-03 | 3.03E-02 | GSE2719 | Homo sapiens | Gastrointestinal stromal tumor | Connective tissue |
140 | 2.59 | 9.60E-03 | 3.01E-02 | GSE7036 | Homo sapiens | Bipolar disorder | Lymphocyte |
141 | 2.57 | 1.00E-02 | 3.07E-02 | GSE1724 | Homo sapiens | Scleroderma | Fibroblast |
142 | 2.56 | 9.70E-03 | 3.02E-02 | GSE3790 | Homo sapiens | Huntington's disease | Caudate nucleus |
143 | 2.55 | 1.25E-02 | 3.68E-02 | GSE6764 | Homo sapiens | Hepatic cirrhosis | Liver |
144 | 2.54 | 1.24E-02 | 3.68E-02 | GSE2457 | Rattus norvegicus | Erectile dysfunction associated with type 2 diabetes mellitus | Penis, NOS |
145 | 2.54 | 1.47E-02 | 4.14E-02 | GSE2457 | Rattus norvegicus | Erectile dysfunction | Penis erectile tissue |
146 | 2.54 | 1.05E-02 | 3.20E-02 | GSE3110 | Rattus norvegicus | Dehydration | Hypothalamus |
147 | 2.53 | 1.22E-02 | 3.64E-02 | GSE2712 | Homo sapiens | Nephroblastoma | Renal tissue |
148 | 2.51 | 1.42E-02 | 4.05E-02 | GSE7999 | Rattus norvegicus | Tachycardia | Myocardial tissue |
149 | 2.51 | 1.29E-02 | 3.77E-02 | GSE609 | Homo sapiens | SCID | Thymic lymphocyte |
150 | 2.49 | 1.19E-02 | 3.58E-02 | GSE1869 | Homo sapiens | Cardiomyopathy | Myocardial tissue |
151 | 2.49 | 1.36E-02 | 3.93E-02 | GSE7621 | Homo sapiens | Parkinson's disease | Substantia nigra |
152 | 2.48 | 1.35E-02 | 3.92E-02 | GSE10971 | Homo sapiens | Serous carcinoma | Fallopian tube |
153 | 2.48 | 1.40E-02 | 4.02E-02 | GSE3418 | Mus musculus | Lung transplant rejection | Trachea |
154 | 2.47 | 1.45E-02 | 4.11E-02 | EXPE-MEXP-476 | Homo sapiens | Cancer of prostate | Endothelial cell |
155 | 2.47 | 1.54E-02 | 4.28E-02 | GSE3184 | Mus musculus | Asthma, allergic | Lung tissue |
156 | 2.46 | 1.49E-02 | 4.16E-02 | GSE4616 | Mus musculus | Type 1 diabetes mellitus | Myocardial tissue |
157 | 2.41 | 1.68E-02 | 4.64E-02 | GSE4612 | Mus musculus | Carcinoma, hepatocellular | Hepatic tissue |
158 | 2.4 | 1.77E-02 | 4.85E-02 | GSE2725 | Homo sapiens | Uterine leiomyoma | Uterus |
159 | 2.39 | 1.81E-02 | 4.90E-02 | GSE3365 | Homo sapiens | Ulcerative colitis | Peripheral blood mononuclear cell |
160 | 2.37 | 1.80E-02 | 4.90E-02 | GSE1813 | Rattus norvegicus | Obesity | Adipose tissue |
161 | 2.36 | 1.87E-02 | 5.03E-02 | GSE4060 | Homo sapiens | Cushing syndrome | Adrenal gland |
162 | 2.35 | 2.07E-02 | 5.50E-02 | GSE1145 | Homo sapiens | Primary cardiomyopathy | Myocardial tissue |
163 | 2.31 | 1.88E-02 | 5.03E-02 | GSE6461 | Mus musculus | Synovial sarcoma | Synovial membrane |
164 | 2.3 | 2.15E-02 | 5.68E-02 | GSE1037 | Homo sapiens | Non-small cell lung cancer | Lung tissue |
165 | 2.27 | 2.29E-02 | 6.01E-02 | GSE10921 | Homo sapiens | Idiopathic fibrosing alveolitis | Fibroblast |
166 | 2.26 | 2.41E-02 | 6.28E-02 | GSE3248 | Mus musculus | Huntington's disease | CNS, brain, cerebellum (MMHCC) |
167 | 2.25 | 2.42E-02 | 6.28E-02 | GSE4788 | Mus musculus | Parkinson's disease | Substantia nigra |
168 | 2.24 | 2.52E-02 | 6.46E-02 | GSE4710 | Mus musculus | Heart injury | Myocardial tissue |
169 | 2.21 | 2.52E-02 | 6.46E-02 | GSE6364 | Homo sapiens | Endometriosis | Endometrium |
170 | 2.2 | 2.68E-02 | 6.83E-02 | GSE1462 | Homo sapiens | CPEO (chronic progressive external ophthalmoplegia) | Muscle, striated (skeletal) (MMHCC) |
171 | 2.19 | 3.00E-02 | 7.56E-02 | GSE1724 | Homo sapiens | Idiopathic fibrosing alveolitis | Fibroblast |
172 | 2.18 | 2.87E-02 | 7.28E-02 | GSE6955 | Homo sapiens | Rett syndrome | frontal cortex |
173 | 2.13 | 3.24E-02 | 8.12E-02 | GSE1017 | Homo sapiens | Myopathy NOS | Skeletal muscle |
174 | 2.13 | 3.39E-02 | 8.45E-02 | GSE2429 | Homo sapiens | Breast cancer | Mammary gland tissue |
175 | 2.12 | 3.57E-02 | 8.79E-02 | GSE6764 | Homo sapiens | Hepatocellular dysplasia | Liver |
176 | 2.11 | 3.64E-02 | 8.92E-02 | GSE4516 | Rattus norvegicus | Smoke inhalation | Lung tissue |
177 | 2.1 | 3.41E-02 | 8.45E-02 | GSE567 | Homo sapiens | Essential thrombocythemia | Megakaryocyte |
178 | 2.09 | 3.92E-02 | 9.39E-02 | EXPE-TABM-176 | Homo sapiens | Irritable bowel syndrome variant of childhood with constipation | Sigmoid colon |
179 | 2.08 | 3.69E-02 | 8.99E-02 | GSE4130 | Rattus norvegicus | Dehydration | Pituitary gland |
180 | 2.07 | 3.72E-02 | 9.01E-02 | GSE9006 | Homo sapiens | Type 2 diabetes mellitus | Peripheral blood mononuclear cell |
181 | 2.06 | 4.00E-02 | 9.40E-02 | GSE2899 | Mus musculus | Type 2 diabetes mellitus | Soleus muscle |
182 | 2.06 | 4.01E-02 | 9.40E-02 | GSE3125 | Rattus norvegicus | Dehydration | Hypothalamus |
183 | 2.06 | 3.99E-02 | 9.40E-02 | GSE3407 | Homo sapiens | Cockayne syndrome | Fibroblast |
184 | 2.06 | 3.79E-02 | 9.13E-02 | GSE2866 | Mus musculus | γ-Hydroxybutyric acidemia | Hippocampus |
185 | 2.05 | 4.07E-02 | 9.49E-02 | GSE2077 | Homo sapiens | Protozoan Infection | Intestinal epithelium |
186 | 2.05 | 4.14E-02 | 9.60E-02 | GSE9006 | Homo sapiens | Type 1 diabetes mellitus | Peripheral blood mononuclear cell |
187 | 2.03 | 4.01E-02 | 9.40E-02 | GSE10123 | Homo sapiens | Premature aging | Skin fibroblast |
188 | 2.01 | 4.45E-02 | 1.01E-01 | GSE3365 | Homo sapiens | Crohn's disease | Peripheral blood mononuclear cell |
189 | 2.01 | 4.33E-02 | 9.99E-02 | GSE1297 | Homo sapiens | Alzheimer's disease | Hippocampus |
190 | 2 | 4.40E-02 | 1.01E-01 | GSE2254 | Mus musculus | Type 1 diabetes mellitus | pancreatic islet |
191 | 2 | 4.57E-02 | 1.03E-01 | GSE3489 | Homo sapiens | HIV encephalitis | frontal cortex |
192 | 2 | 4.44E-02 | 1.01E-01 | GSE3203 | Mus musculus | Influenza | B-cell lymphocyte |
193 | 1.99 | 4.67E-02 | 1.05E-01 | GSE2559 | Homo sapiens | Pulmonary hypertension, primary | Pulmonary artery |
194 | 1.98 | 4.76E-02 | 1.06E-01 | GSE3807 | Homo sapiens | Aplastic anemia | Bone marrow |
195 | 1.98 | 4.85E-02 | 1.07E-01 | GSE4105 | Rattus norvegicus | Myocardial infarction | Myocardial tissue |
196 | 1.96 | 4.72E-02 | 1.06E-01 | GSE4479 | Mus musculus | Sepsis | Splenocyte |
197 | 1.95 | 5.26E-02 | 1.15E-01 | GSE3676 | Mus musculus | Infertility due to azoospermia | Testicular tissue |
198 | 1.94 | 5.21E-02 | 1.15E-01 | GSE10064 | Homo sapiens | MS | B-cell lymphocyte |
199 | 1.93 | 5.48E-02 | 1.17E-01 | GSE5090 | Homo sapiens | Polycystic ovary syndrome | Adipose tissue |
200 | 1.93 | 5.43E-02 | 1.17E-01 | GSE11 | Mus musculus | Type 1 diabetes mellitus | Thymic epithelial cell |
201 | 1.92 | 5.28E-02 | 1.15E-01 | GSE582 | Mus musculus | Transplanted heart complication | Myocardial tissue |
202 | 1.92 | 5.44E-02 | 1.17E-01 | GSE10586 | Homo sapiens | Type 1 diabetes mellitus | T lymphocyte |
203 | 1.92 | 5.77E-02 | 1.21E-01 | GSE2049 | Homo sapiens | AML | Haematopoietic stem cell |
204 | 1.91 | 5.56E-02 | 1.18E-01 | GSE11208 | Homo sapiens | Nicotine addiction | Ganglioneuroblastoma |
205 | 1.91 | 5.61E-02 | 1.18E-01 | GSE5538 | Mus musculus | Hepatic lipidosis | Hepatic Tissue |
206 | 1.9 | 5.37E-02 | 1.16E-01 | EXPE-MEXP-692 | Homo sapiens | Barrett esophagus | Esophagus |
207 | 1.9 | 5.60E-02 | 1.18E-01 | GSE1659 | Mus musculus | Type 1 diabetes mellitus | Muscle, striated (skeletal) (MMHCC) |
208 | 1.89 | 6.00E-02 | 1.25E-01 | GSE4170 | Homo sapiens | CML | Haematopoietic stem cell |
209 | 1.88 | 6.33E-02 | 1.31E-01 | EXPE-MEXP-692 | Homo sapiens | Adenocarcinoma of esophagus | Esophagus |
210 | 1.86 | 6.21E-02 | 1.29E-01 | GSE422 | Mus musculus | Carcinoma in situ of small intestine | Intestinal epithelium |
211 | 1.82 | 6.93E-02 | 1.41E-01 | GSE1822 | Homo sapiens | Ewing's sarcoma | Renal tissue |
212 | 1.81 | 6.69E-02 | 1.37E-01 | GSE755 | Homo sapiens | Osteolysis | Leukocyte, lymphocyte, B lymphocyte, plasma cell (MMHCC) |
213 | 1.81 | 6.60E-02 | 1.36E-01 | GSE3004 | Homo sapiens | Asthma, allergic | Bronchial epithelium |
214 | 1.78 | 7.26E-02 | 1.47E-01 | GSE4060 | Homo sapiens | ACTH-dependent Cushing syndrome | Adrenal gland |
215 | 1.76 | 7.71E-02 | 1.54E-01 | GSE4120 | Mus musculus | Arrhythmogenic right ventricular cardiomyopathy | Myocardial tissue |
216 | 1.76 | 8.01E-02 | 1.59E-01 | GSE3790 | Homo sapiens | Huntington's disease | frontal cortex |
217 | 1.76 | 7.70E-02 | 1.54E-01 | GSE9800 | Homo sapiens | Cardiomyopathy, dilated | Myocardial tissue |
218 | 1.71 | 8.68E-02 | 1.70E-01 | GSE3915 | Mus musculus | Cancer of the intestine | Small bowel |
219 | 1.69 | 9.30E-02 | 1.80E-01 | GSE5581 | Mus musculus | Retinoschisis | Retina |
220 | 1.68 | 8.96E-02 | 1.75E-01 | GSE868 | Mus musculus | Familial hypophosphatemic rickets | Renal tissue |
221 | 1.68 | 8.99E-02 | 1.75E-01 | EXPE-TABM-176 | Homo sapiens | IBS | Sigmoid colon |
222 | 1.66 | 9.61E-02 | 1.85E-01 | GSE6965 | Homo sapiens | Infection by Aspergillus fumigatus | Dendritic cell |
223 | 1.66 | 9.71E-02 | 1.87E-01 | GSE6012 | Homo sapiens | Eczema | Integument |
224 | 1.65 | 9.80E-02 | 1.87E-01 | GSE3554 | Mus musculus | Glaucoma | Retina |
225 | 1.65 | 1.00E-01 | 1.90E-01 | GSE2223 | Homo sapiens | Glioblastoma | CNS, brain (MMHCC) |
226 | 1.63 | 9.98E-02 | 1.90E-01 | EXPE-TABM-26 | Homo sapiens | Cancer of prostate | Prostate |
227 | 1.62 | 1.03E-01 | 1.94E-01 | GSE4172 | Homo sapiens | Viral cardiomyopathy | Myocardial tissue |
228 | 1.6 | 1.08E-01 | 2.01E-01 | GSE2191 | Homo sapiens | AML | Mononuclear leukocyte |
229 | 1.6 | 1.08E-01 | 2.01E-01 | GSE2155 | Homo sapiens | Breast cancer | Epithelial cell |
230 | 1.56 | 1.18E-01 | 2.16E-01 | GSE1299 | Homo sapiens | Breast cancer | Mammary epithelium |
231 | 1.55 | 1.15E-01 | 2.13E-01 | GSE3320 | Homo sapiens | COPD | Bronchial epithelium |
232 | 1.55 | 1.19E-01 | 2.17E-01 | GSE5774 | Homo sapiens | Nonspecific interstitial pneumonia | Lung tissue |
233 | 1.55 | 1.18E-01 | 2.16E-01 | GSE6710 | Homo sapiens | Psoriasis vulgaris | Skin tissue |
234 | 1.53 | 1.29E-01 | 2.31E-01 | GSE4250 | Homo sapiens | Hereditary gingival fibromatosis | Gingiva |
235 | 1.53 | 1.24E-01 | 2.25E-01 | GSE5364 | Homo sapiens | Cancer of thyroid | Thyroid |
236 | 1.53 | 1.18E-01 | 2.16E-01 | GSE3583 | Mus musculus | Huntington's disease | CNS, brain, striatum (MMHCC) |
237 | 1.52 | 1.30E-01 | 2.32E-01 | GSE12654 | Homo sapiens | Bipolar disorder | Cerebral cortex |
238 | 1.52 | 1.29E-01 | 2.31E-01 | GSE973 | Homo sapiens | Funisitis | Umbilical blood |
239 | 1.51 | 1.32E-01 | 2.34E-01 | GSE12649 | Homo sapiens | Bipolar disorder | Cerebral cortex |
240 | 1.5 | 1.33E-01 | 2.35E-01 | GSE925 | Rattus norvegicus | Cardiac hypertrophy | Cardiomyocyte |
241 | 1.48 | 1.38E-01 | 2.42E-01 | GSE3544 | Mus musculus | MODY | Pancreatic islet |
242 | 1.47 | 1.42E-01 | 2.46E-01 | GSE420 | Homo sapiens | Atherosclerosis | Aorta smooth muscle tissue |
243 | 1.47 | 1.37E-01 | 2.42E-01 | GSE422 | Mus musculus | Adenoma of small intestine | Intestinal epithelium |
244 | 1.46 | 1.41E-01 | 2.46E-01 | EXPE-TABM-36 | Homo sapiens | Hepatocellular adenoma | Hepatocyte |
245 | 1.45 | 1.38E-01 | 2.42E-01 | GSE4302 | Homo sapiens | Asthma | Epithelial cell |
246 | 1.45 | 1.44E-01 | 2.50E-01 | GSE5370 | Homo sapiens | Dermatomyositis | Muscle, striated (skeletal) (MMHCC) |
247 | 1.42 | 1.53E-01 | 2.61E-01 | GSE2172 | Mus musculus | Colitis | Intestine, large intestine, colon (MMHCC) |
248 | 1.41 | 1.55E-01 | 2.63E-01 | GSE11750 | Homo sapiens | Senescence | Muscle, striated (skeletal) (MMHCC) |
249 | 1.41 | 1.56E-01 | 2.63E-01 | GSE3 | Homo sapiens | Chromophobe cell carcinoma of kidney | Renal cell |
250 | 1.41 | 1.52E-01 | 2.61E-01 | GSE2705 | Homo sapiens | Primary open angle glaucoma | Optic disk |
251 | 1.37 | 1.68E-01 | 2.80E-01 | GSE3860 | Homo sapiens | Progeria | Fibroblast |
252 | 1.37 | 1.73E-01 | 2.86E-01 | GSE674 | Homo sapiens | Senescence | Muscle, striated (skeletal) (MMHCC) |
253 | 1.36 | 1.72E-01 | 2.84E-01 | GSE2549 | Homo sapiens | Malignant mesothelioma of pleura | Pleura |
254 | 1.36 | 1.71E-01 | 2.84E-01 | GSE1466 | Homo sapiens | Lymphoblastic leukemia | T lymphocyte |
255 | 1.33 | 1.82E-01 | 2.97E-01 | GSE1611 | Mus musculus | Down syndrome | CNS, brain, cerebellum (MMHCC) |
256 | 1.33 | 1.79E-01 | 2.93E-01 | GSE997 | Homo sapiens | Essential thrombocythemia | Megakaryocyte |
257 | 1.32 | 1.91E-01 | 3.09E-01 | GSE6798 | Homo sapiens | Polycystic ovary syndrome | Skeletal muscle |
258 | 1.32 | 1.83E-01 | 2.98E-01 | GSE3790 | Homo sapiens | Huntington's disease | CNS, brain, cerebellum (MMHCC) |
259 | 1.31 | 1.87E-01 | 3.03E-01 | GSE2503 | Homo sapiens | Actinic keratosis | Skin tissue |
260 | 1.29 | 1.94E-01 | 3.12E-01 | GSE1010 | Homo sapiens | Familial combined hyperlipidemia | Lymphoblast |
261 | 1.27 | 2.00E-01 | 3.17E-01 | GSE1028 | Homo sapiens | Scott syndrome | B-cell lymphocyte |
262 | 1.27 | 1.98E-01 | 3.16E-01 | GSE5388 | Homo sapiens | Bipolar disorder | Frontal cortex |
263 | 1.27 | 2.00E-01 | 3.17E-01 | GSE2067 | Homo sapiens | Hepatitis C infection | Hepatocyte |
264 | 1.26 | 2.04E-01 | 3.22E-01 | GSE3280 | Homo sapiens | Acute monocytic leukemia | Blood monocyte |
265 | 1.26 | 2.07E-01 | 3.24E-01 | GSE642 | Mus musculus | Type 2 diabetes mellitus | Renal tissue |
266 | 1.26 | 2.07E-01 | 3.24E-01 | GSE5281 | Homo sapiens | Alzheimer's disease | Superior frontal gyrus |
267 | 1.21 | 2.28E-01 | 3.54E-01 | GSE11348 | Homo sapiens | Rhinovirus infection | Nose |
268 | 1.2 | 2.34E-01 | 3.61E-01 | GSE7486 | Homo sapiens | Epilepsy | Lymphoblast |
269 | 1.16 | 2.46E-01 | 3.74E-01 | GSE3384 | Mus musculus | Nemaline myopathy | Tibialis Muscle |
270 | 1.16 | 2.45E-01 | 3.73E-01 | GSE473 | Homo sapiens | Asthma | CD4-positive lymphocyte |
271 | 1.16 | 2.45E-01 | 3.73E-01 | GSE474 | Homo sapiens | Obesity | Muscle, striated (skeletal) (MMHCC) |
272 | 1.14 | 2.50E-01 | 3.78E-01 | EXPE-MEXP-669 | NULL | Neuroblastoma | Adrenal cortex |
273 | 1.12 | 2.62E-01 | 3.95E-01 | GSE3889 | Mus musculus | Hypercholesterolemia | Hepatic tissue |
274 | 1.11 | 2.66E-01 | 3.97E-01 | GSE2175 | Homo sapiens | Adenoma of pituitary gland | Pituitary gland |
275 | 1.1 | 2.71E-01 | 4.03E-01 | GSE3925 | Mus musculus | Hyperreactive airway disease | Lung tissue |
276 | 1.09 | 2.79E-01 | 4.13E-01 | GSE10162 | Mus musculus | Nephrolithiasis | Kidney |
277 | 1.09 | 2.62E-01 | 3.95E-01 | GSE2470 | Rattus norvegicus | Type 2 diabetes mellitus | Pancreas |
278 | 1.08 | 2.77E-01 | 4.10E-01 | GSE362 | Homo sapiens | Senescence | Muscle, striated (skeletal) (MMHCC) |
279 | 1.06 | 2.87E-01 | 4.23E-01 | GSE2973 | Mus musculus | Infection by Y. enterocolitica | Macrophage |
280 | 1.04 | 2.98E-01 | 4.35E-01 | GSE4785 | Homo sapiens | Simian acquired immune deficiency syndrome | T lymphocyte |
281 | 1.04 | 2.97E-01 | 4.35E-01 | GSE923 | Homo sapiens | Pseudomonas infection | Lung tissue |
282 | 1.02 | 3.07E-01 | 4.46E-01 | GSE12654 | Homo sapiens | Depression | Cerebral cortex |
283 | 1.01 | 3.08E-01 | 4.47E-01 | GSE2053 | Homo sapiens | RA | Synovial membrane |
284 | 1.01 | 3.14E-01 | 4.54E-01 | GSE1037 | Homo sapiens | Adenocarcinoma of lung | Lung tissue |
285 | 1 | 3.18E-01 | 4.58E-01 | GSE4333 | Mus musculus | Lymphatic edema | Skin tissue |
286 | 0.99 | 3.22E-01 | 4.62E-01 | GSE10964 | Mus musculus | COPD | Lung |
287 | 0.99 | 3.28E-01 | 4.69E-01 | GSE2657 | Homo sapiens | Sarcoidosis | T lymphocyte |
288 | 0.96 | 3.41E-01 | 4.81E-01 | GSE1767 | Homo sapiens | Huntington's disease | Blood |
289 | 0.96 | 3.35E-01 | 4.77E-01 | GSE7753 | Homo sapiens | JRA | Peripheral blood mononuclear cell |
290 | 0.95 | 3.40E-01 | 4.81E-01 | GSE4125 | Homo sapiens | Adenocarcinoma of kidney | Kidney |
291 | 0.94 | 3.46E-01 | 4.87E-01 | GSE8762 | Homo sapiens | Huntington's disease | Lymphocyte |
292 | 0.93 | 3.48E-01 | 4.88E-01 | GSE5788 | Homo sapiens | Leukemia, chronic T cell | T lymphocyte |
293 | 0.92 | 3.56E-01 | 4.98E-01 | GSE483 | Mus musculus | Asthma, allergic | Lung tissue |
294 | 0.91 | 3.58E-01 | 4.99E-01 | GSE2566 | Rattus norvegicus | Neurogenic muscular atrophy | Muscle, striated (skeletal) (MMHCC) |
295 | 0.91 | 3.60E-01 | 4.99E-01 | GSE2600 | Homo sapiens | Anaplasmosis | Leukemic cell |
296 | 0.91 | 3.68E-01 | 5.06E-01 | GSE2127 | Mus musculus | Carcinoma, hepatocellular | Hepatic tissue |
297 | 0.91 | 3.59E-01 | 4.99E-01 | GSE2052 | Homo sapiens | MCTD | Lung tissue |
298 | 0.84 | 3.85E-01 | 5.26E-01 | GSE2276 | Mus musculus | Asthma, allergic | Lung tissue |
299 | 0.84 | 4.07E-01 | 5.52E-01 | GSE4707 | Homo sapiens | Preeclampsia | Placenta |
300 | 0.81 | 4.22E-01 | 5.68E-01 | GSE3871 | Homo sapiens | Androgen insensitivity syndrome | Fibroblast |
301 | 0.81 | 4.17E-01 | 5.63E-01 | GSE1606 | Mus musculus | Turner syndrome | CNS, brain (MMHCC) |
302 | 0.8 | 4.27E-01 | 5.70E-01 | GSE1674 | Mus musculus | Hypertension | Adrenal gland |
303 | 0.8 | 4.28E-01 | 5.70E-01 | GSE3195 | Mus musculus | Hypoxia | Fibroblast |
304 | 0.79 | 4.28E-01 | 5.70E-01 | GSE475 | Homo sapiens | COPD | Muscle, striated (skeletal), diaphragm (MMHCC) |
305 | 0.79 | 4.34E-01 | 5.75E-01 | GSE1872 | Rattus norvegicus | Breast cancer | Mammary gland tissue |
306 | 0.79 | 4.29E-01 | 5.70E-01 | GSE3868 | Homo sapiens | Cancer of prostate | Prostate |
307 | 0.76 | 4.46E-01 | 5.87E-01 | EXPE-MEXP-669 | NULL | Neuroblastoma | Adrenal cortex |
308 | 0.76 | 4.43E-01 | 5.85E-01 | GSE5109 | Homo sapiens | Obesity | Muscle, striated (skeletal) (MMHCC) |
309 | 0.73 | 4.64E-01 | 6.07E-01 | GSE1413 | Mus musculus | Cancer of prostate | Prostate |
310 | 0.72 | 4.76E-01 | 6.18E-01 | GSE5281 | Homo sapiens | Alzheimer's Disease | Middle temporal gyrus |
311 | 0.72 | 4.71E-01 | 6.15E-01 | GSE3384 | Mus musculus | Nemaline myopathy | Extensor digitorum longus muscle |
312 | 0.69 | 4.89E-01 | 6.32E-01 | GSE2223 | Homo sapiens | Astrocytoma | CNS, brain (MMHCC) |
313 | 0.68 | 4.97E-01 | 6.42E-01 | EXPE-MEXP-476 | Homo sapiens | Cancer of prostate | Endothelial cell |
314 | 0.68 | 4.99E-01 | 6.42E-01 | EXPE-MEXP-476 | Homo sapiens | Cancer of prostate | Endothelial cell |
315 | 0.66 | 5.10E-01 | 6.54E-01 | GSE9877 | Homo sapiens | Sickle cell anemia | Endothelial cell |
316 | 0.65 | 5.18E-01 | 6.62E-01 | GSE3026 | Homo sapiens | Bacterial infection | Peripheral blood mononuclear cell |
317 | 0.63 | 5.30E-01 | 6.76E-01 | GSE128 | Mus musculus | Retinitis pigmentosa | Retina |
318 | 0.61 | 5.34E-01 | 6.77E-01 | GSE1379 | Homo sapiens | Breast cancer | Mammary gland tissue |
319 | 0.58 | 5.63E-01 | 7.02E-01 | GSE867 | Mus musculus | Hepatitis, autoimmune | Hepatic tissue |
320 | 0.58 | 5.63E-01 | 7.02E-01 | GSE465 | Homo sapiens | DMD | Muscle, striated (skeletal) (MMHCC) |
321 | 0.58 | 5.61E-01 | 7.02E-01 | GSE1871 | Mus musculus | Acute lung injury | Lung tissue |
322 | 0.57 | 5.65E-01 | 7.02E-01 | GSE5900 | Homo sapiens | MGUS | Bone marrow |
323 | 0.57 | 5.70E-01 | 7.02E-01 | GSE2223 | Homo sapiens | Oligodendroglioma | CNS, brain (MMHCC) |
324 | 0.57 | 5.65E-01 | 7.02E-01 | GSE1055 | Rattus norvegicus | Cardiac hypertrophy | Cardiomyocyte |
325 | 0.57 | 5.70E-01 | 7.02E-01 | GSE4748 | Homo sapiens | Bacterial infection | Dendritic cell |
326 | 0.57 | 5.73E-01 | 7.03E-01 | GSE3384 | Mus musculus | Nemaline myopathy | Muscle, striated (skeletal), diaphragm (MMHCC) |
327 | 0.57 | 5.70E-01 | 7.02E-01 | GSE2236 | Mus musculus | Congestive heart disease | Myocardial tissue |
328 | 0.56 | 5.74E-01 | 7.03E-01 | GSE1008 | Mus musculus | DMD | Extraocular muscle |
329 | 0.53 | 5.90E-01 | 7.15E-01 | GSE1472 | Mus musculus | DMD | Extraocular muscle |
330 | 0.53 | 6.02E-01 | 7.20E-01 | GSE85 | Mus musculus | APECED | Thymic epithelial cell |
331 | 0.53 | 5.92E-01 | 7.15E-01 | GSE1849 | Homo sapiens | Sickle cell anemia | Pulmonary artery |
332 | 0.52 | 5.99E-01 | 7.19E-01 | GSE3311 | Rattus norvegicus | Alcohol poisoning | Pancreas |
333 | 0.51 | 6.03E-01 | 7.21E-01 | GSE2503 | Homo sapiens | Squamous cell carcinoma | Skin tissue |
334 | 0.5 | 6.17E-01 | 7.35E-01 | GSE2899 | Mus musculus | Type 2 diabetes mellitus | Hepatic tissue |
335 | 0.48 | 6.26E-01 | 7.42E-01 | GSE1739 | Homo sapiens | SARS | Peripheral blood mononuclear cell |
336 | 0.46 | 6.46E-01 | 7.57E-01 | GSE5900 | Homo sapiens | Smoldering multiple myeloma | Bone marrow |
337 | 0.45 | 6.64E-01 | 7.74E-01 | GSE4678 | Mus musculus | Ventricular hypertrophy | Myocardial tissue |
338 | 0.43 | 6.63E-01 | 7.74E-01 | GSE4128 | Mus musculus | Adenovirus infection | Hepatic tissue |
339 | 0.42 | 6.79E-01 | 7.81E-01 | GSE11889 | Homo sapiens | CML | Hematopoietic stem cell |
340 | 0.42 | 6.72E-01 | 7.79E-01 | GSE2779 | Homo sapiens | Vitamin B 12 deficiency | Bone marrow stem cell |
341 | 0.4 | 6.89E-01 | 7.90E-01 | GSE3 | Homo sapiens | Clear cell carcinoma of kidney | Renal cell |
342 | 0.38 | 7.02E-01 | 7.97E-01 | GSE9692 | Homo sapiens | Septic shock | Whole blood |
343 | 0.38 | 7.10E-01 | 8.01E-01 | GSE6740 | Homo sapiens | HIV | T lymphocyte |
344 | 0.36 | 7.13E-01 | 8.03E-01 | GSE121 | Homo sapiens | Type 2 diabetes mellitus | Muscle tissue |
345 | 0.36 | 7.25E-01 | 8.14E-01 | GSE1402 | Homo sapiens | Spondyloarthropathy | Peripheral blood mononuclear cell |
346 | 0.34 | 7.34E-01 | 8.20E-01 | GSE2271 | Mus musculus | Hypoxia | Heart |
347 | 0.34 | 7.40E-01 | 8.21E-01 | GSE2466 | Homo sapiens | Lymphocytic leukemia, chronic, B Cell | PBL |
348 | 0.34 | 7.37E-01 | 8.21E-01 | GSE1751 | Homo sapiens | Huntington's disease | Blood |
349 | 0.28 | 7.76E-01 | 8.48E-01 | GSE10211 | Mus musculus | Sendai virus infection | Tracheal epithelium |
350 | 0.27 | 7.86E-01 | 8.57E-01 | GSE2379 | Homo sapiens | Hypopharyngeal cancer | Pharynx |
351 | 0.25 | 8.01E-01 | 8.70E-01 | GSE2884 | Rattus norvegicus | Neurological pain disorder | Dorsal root ganglia |
352 | 0.24 | 8.02E-01 | 8.70E-01 | GSE1560 | Mus musculus | Atherosclerosis | Aorta smooth muscle tissue |
353 | 0.19 | 8.51E-01 | 9.11E-01 | GSE18803 | Rattus norvegicus | Neurological pain disorder | CNS, spinal cord (MMHCC) |
354 | 0.17 | 8.63E-01 | 9.18E-01 | GSE1124 | Homo sapiens | Malaria | Blood |
355 | 0.17 | 8.69E-01 | 9.19E-01 | EXPE-MEXP-1050 | Homo sapiens | IUGR | Decidua basalis |
356 | 0.15 | 8.82E-01 | 9.28E-01 | GSE4697 | Mus musculus | Obesity | Adipose tissue |
357 | 0.12 | 9.02E-01 | 9.43E-01 | GSE3249 | Mus musculus | Leber congenital amaurosis | Retina |
358 | 0.12 | 9.02E-01 | 9.43E-01 | GSE1852 | Mus musculus | Marfan’s syndrome | Myocardial tissue |
359 | 0.08 | 9.34E-01 | 9.66E-01 | GSE7654 | Rattus norvegicus | Hepatitis | Liver |
360 | 0.08 | 9.35E-01 | 9.66E-01 | GSE2504 | Homo sapiens | HIV | T lymphocyte |
361 | 0.08 | 9.39E-01 | 9.66E-01 | GSE1710 | Homo sapiens | Ulcerative colitis | Sigmoid colon |
362 | 0.08 | 9.40E-01 | 9.66E-01 | GSE3167 | Homo sapiens | Urothelial carcinoma | Urothelium |
363 | 0.07 | 9.45E-01 | 9.66E-01 | GSE5281 | Homo sapiens | Alzheimer's disease | Entorhinal cortex |
364 | 0.07 | 9.46E-01 | 9.66E-01 | GSE3586 | Homo sapiens | Cardiomyopathy, dilated | Myocardial tissue |
365 | 0.04 | 9.70E-01 | 9.88E-01 | GSE10758 | Homo sapiens | Down syndrome | Fetus |
366 | 0.02 | 9.82E-01 | 9.89E-01 | GSE15966 | Homo sapiens | Gastrointestinal stromal tumor | Gastric tissue |
367 | 0.01 | 9.94E-01 | 9.96E-01 | GSE11969 | Homo sapiens | Small cell carcinoma of lung | Lung tissue |
368 | 0 | 9.98E-01 | 9.98E-01 | GSE4482 | Homo sapiens | Cancer of cervix | Cervix |
369 | −0.01 | 9.93E-01 | 9.96E-01 | GSE11393 | Homo sapiens | Familial combined hyperlipidemia | Blood monocyte |
370 | −0.02 | 9.81E-01 | 9.89E-01 | GSE10474 | Homo sapiens | Acute lung injury | Whole blood |
371 | −0.02 | 9.81E-01 | 9.89E-01 | GSE574 | Homo sapiens | Purpura, idiopathic thrombocytopenic | T lymphocyte |
372 | −0.02 | 9.80E-01 | 9.89E-01 | GSE3827 | Homo sapiens | CBCL | Skin tissue |
373 | −0.03 | 9.76E-01 | 9.89E-01 | GSE8835 | Homo sapiens | B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma | Peripheral blood mononuclear cell |
374 | −0.07 | 9.42E-01 | 9.66E-01 | GSE2779 | Homo sapiens | Folic acid deficiency | Bone marrow stem cell |
375 | −0.1 | 9.19E-01 | 9.54E-01 | GSE860 | Homo sapiens | PTSD | Peripheral blood mononuclear cell |
376 | −0.11 | 9.18E-01 | 9.54E-01 | GSE2935 | Mus musculus | Sendai virus infection | Macrophage |
377 | −0.11 | 9.15E-01 | 9.54E-01 | GSE4483 | Homo sapiens | Hypoxia | Astrocyte |
378 | −0.14 | 8.89E-01 | 9.34E-01 | GSE1650 | Homo sapiens | COPD | Lung tissue |
379 | −0.16 | 8.74E-01 | 9.23E-01 | EXPE-MEXP-1278 | Rattus norvegicus | Arteriotomy | Carotid artery |
380 | −0.17 | 8.68E-01 | 9.19E-01 | GSE1541 | Homo sapiens | Lung injury | Lung tissue |
381 | −0.18 | 8.52E-01 | 9.11E-01 | GSE2899 | Mus musculus | Type 2 diabetes mellitus | pancreatic islet |
382 | −0.19 | 8.55E-01 | 9.12E-01 | GSE935 | Homo sapiens | Granulomatous disease, chronic | Blood neutrophil |
383 | −0.19 | 8.42E-01 | 9.06E-01 | GSE2171 | Homo sapiens | HIV infection | Peripheral blood mononuclear cell |
384 | −0.2 | 8.46E-01 | 9.08E-01 | GSE4036 | Homo sapiens | Schizophrenia | CNS, brain, cerebellum (MMHCC) |
385 | −0.22 | 8.27E-01 | 8.93E-01 | GSE14245 | Homo sapiens | Malignant tumor of pancreas | Saliva |
386 | −0.24 | 8.06E-01 | 8.72E-01 | GSE2459 | Mus musculus | Hypertrophy, left ventricular | Myocardial tissue |
387 | −0.29 | 7.69E-01 | 8.44E-01 | GSE1818 | Homo sapiens | Cancer of the testis | Testis |
388 | −0.29 | 7.71E-01 | 8.44E-01 | GSE10789 | Homo sapiens | Leukemia, adult T cell | Blood monocyte |
389 | −0.3 | 7.66E-01 | 8.43E-01 | GSE2368 | Mus musculus | Ventilator-associated lung injury | Lung tissue |
390 | −0.32 | 7.59E-01 | 8.38E-01 | GSE11 | Mus musculus | Type 1 diabetes mellitus | Splenic tissue |
391 | −0.32 | 7.44E-01 | 8.24E-01 | GSE2507 | Mus musculus | Muscular dystrophy | Myocardial tissue |
392 | −0.34 | 7.39E-01 | 8.21E-01 | GSE11969 | Homo sapiens | Adenocarcinoma of lung | Lung tissue |
393 | −0.34 | 7.29E-01 | 8.17E-01 | GSE3 | Homo sapiens | Chromophil carcinoma of kidney | Renal cell |
394 | −0.37 | 7.05E-01 | 7.99E-01 | GSE1710 | Homo sapiens | Crohn's disease | Sigmoid colon |
395 | −0.38 | 6.97E-01 | 7.93E-01 | GSE1987 | Homo sapiens | Squamous cell carcinoma | Lung tissue |
396 | −0.4 | 6.96E-01 | 7.93E-01 | GSE1719 | Homo sapiens | Macular degeneration | Fibroblast |
397 | −0.4 | 6.91E-01 | 7.90E-01 | GSE2737 | Homo sapiens | Psoriasis vulgaris | Epidermis |
398 | −0.41 | 6.78E-01 | 7.81E-01 | GSE2729 | Homo sapiens | Rotavirus infection of children | Peripheral blood mononuclear cell |
399 | −0.41 | 6.78E-01 | 7.81E-01 | GSE14577 | Homo sapiens | CFS | Peripheral blood mononuclear cell |
400 | −0.43 | 6.66E-01 | 7.74E-01 | GSE363 | Mus musculus | Atherosclerosis | Hepatic tissue |
401 | −0.46 | 6.46E-01 | 7.57E-01 | GSE1987 | Homo sapiens | Adenocarcinoma of lung | Lung tissue |
402 | −0.47 | 6.42E-01 | 7.57E-01 | GSE1786 | Homo sapiens | Senescence | Muscle, striated (skeletal) (MMHCC) |
403 | −0.47 | 6.33E-01 | 7.48E-01 | GSE2018 | Homo sapiens | Lung transplant rejection | Lung tissue |
404 | −0.49 | 6.26E-01 | 7.42E-01 | GSE5113 | Mus musculus | Intestinal flagellate infection | Small intestinal lamina propria |
405 | −0.52 | 5.99E-01 | 7.19E-01 | GSE4646 | Homo sapiens | Meningococcal infection | Umbilical vein |
406 | −0.54 | 5.89E-01 | 7.15E-01 | GSE3934 | Homo sapiens | Meningococcal infection | Blood |
407 | −0.54 | 5.86E-01 | 7.13E-01 | GSE11969 | Homo sapiens | Squamous cell carcinoma of lung | Lung tissue |
408 | −0.55 | 5.80E-01 | 7.08E-01 | GSE3606 | Homo sapiens | Overexertion | Leukocyte |
409 | −0.59 | 5.55E-01 | 6.99E-01 | GSE2378 | Homo sapiens | Glaucoma | Astrocyte |
410 | −0.61 | 5.43E-01 | 6.86E-01 | GSE11969 | Homo sapiens | Large cell carcinoma of lung | Lung tissue |
411 | −0.63 | 5.34E-01 | 6.77E-01 | GSE1907 | Homo sapiens | Sarcoidosis | Blood corpuscle |
412 | −0.7 | 4.74E-01 | 6.17E-01 | GSE3100 | Mus musculus | Cystic fibrosis | Lung |
413 | −0.74 | 4.62E-01 | 6.07E-01 | GSE7277 | Mus musculus | Arthritis | frontal cortex |
414 | −0.85 | 3.97E-01 | 5.39E-01 | GSE3384 | Mus musculus | Nemaline myopathy | Gastrocnemius muscle |
415 | −0.85 | 3.95E-01 | 5.38E-01 | GSE1363 | Mus musculus | Primary pulmonary hypoplasia | Lung tissue |
416 | −0.86 | 3.85E-01 | 5.26E-01 | GSE11886 | Homo sapiens | Ankylosing spondylitis | macrophage |
417 | −0.9 | 3.66E-01 | 5.05E-01 | GSE1542 | Homo sapiens | Duct cell carcinoma | Pancreas |
418 | −0.94 | 3.40E-01 | 4.81E-01 | GSE3414 | Mus musculus | SCID | Lung tissue |
419 | −1.04 | 2.98E-01 | 4.35E-01 | GSE2223 | Homo sapiens | Anaplastic oligoastrocytoma | CNS, brain (MMHCC) |
420 | −1.11 | 2.66E-01 | 3.97E-01 | GSE1615 | Homo sapiens | Polycystic ovary syndrome | Theca cells |
421 | −1.17 | 2.41E-01 | 3.70E-01 | GSE1402 | Homo sapiens | Chronic polyarticular juvenile rheumatoid arthritis | Peripheral blood mononuclear cell |
422 | −1.18 | 2.37E-01 | 3.65E-01 | GSE5786 | Mus musculus | Huntington's disease | CNS, brain, striatum (MMHCC) |
423 | −1.23 | 2.19E-01 | 3.42E-01 | GSE3284 | Homo sapiens | Bacterial infection | Leukocyte |
424 | −1.28 | 2.01E-01 | 3.18E-01 | GSE3512 | Rattus norvegicus | Hyperlipidemia | Hepatic tissue |
425 | −1.29 | 1.97E-01 | 3.16E-01 | EXPE-MEXP-357 | Rattus norvegicus | Hypertension | Left ventricle |
426 | −1.36 | 1.75E-01 | 2.88E-01 | GSE4630 | Homo sapiens | Hypoxia | macrophage |
427 | −1.38 | 1.68E-01 | 2.80E-01 | GSE1294 | Mus musculus | Down’s syndrome | CNS, brain (MMHCC) |
428 | −1.39 | 1.61E-01 | 2.70E-01 | GSE5112 | Mus musculus | Intestinal flagellate infection | Intestinal epithelium |
429 | −1.42 | 1.53E-01 | 2.61E-01 | GSE2006 | Homo sapiens | Essential thrombocythemia | Thrombocyte |
430 | −1.44 | 1.46E-01 | 2.52E-01 | GSE1402 | Homo sapiens | Pauciarticular juvenile arthritis | Peripheral blood mononuclear cell |
431 | −1.54 | 1.24E-01 | 2.25E-01 | EXPE-MEXP-1283 | Homo sapiens | Hodgkin’s lymphoma | Peripheral blood mononuclear cell |
432 | −1.63 | 1.03E-01 | 1.94E-01 | GSE1919 | Homo sapiens | RA | Synovial membrane |
433 | −1.73 | 8.56E-02 | 1.69E-01 | GSE2395 | Homo sapiens | Cystic fibrosis | Bronchial epithelium |
434 | −1.74 | 8.09E-02 | 1.60E-01 | GSE6435 | Mus musculus | Bacterial infection | Leukocyte, monocyte, macrophage (MMHCC) |
435 | −1.76 | 7.44E-02 | 1.50E-01 | GSE1919 | Homo sapiens | Osteoarthritis | Synovial membrane |
436 | −2.77 | 4.80E-03 | 1.74E-02 | GSE10121 | Homo sapiens | Squamous cell carcinoma of buccal mucosa | Buccal mucosa |
We computationally matched the juvenile plasticity signature to 436 disease signatures derived from public microarray data. This systematic method applies a rank-based molecular matching algorithm to determine the molecular concordance between the plasticity signature and a given disease signature, where high scores indicate that plasticity genes are significantly dysregulated by the disease and low scores indicate that the disease has no impact on plasticity genes. Highly ranked diseases included not only brain disorders known to disrupt plasticity such as Huntington’s disease, but also non-neurologic disorders (e.g., bacterial infections, inflammatory bowel disease, metabolic diseases), suggesting that a broad range of disease states may impact molecular pathways involved in plasticity. ALS, Amyotrophic lateral sclerosis; AML, acute myeloid leukemia; APECED, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy; CBCL, cutaneous B-cell lymphoma; CFS, chronic fatigue syndrome; CML, chronic myeloid leukemia; COPD, chronic obstructive pulmonary disease; DMD, Duchenne muscular dystrophy; FDIU, fetal death in utero; FDR, false discovery rate; GERD, gastroesophageal reflux disease; HIV, human immunodeficiency virus; IBD, inflammatory bowel disease; IBS, irritable bowel syndrome; IUGR, intrauterine growth retardation; JRA, juvenile rheumatoid arthritis; LGLL, large granular lymphocytic leukemia; MCTD, mixed connective tissue disease; MDS, myelodysplastic syndrome; MGUS, Monoclonal gammopathy of undetermined significance; MMHCC, Mouse Models of Human Cancers Consortium; MODY, maturity onset diabetes in youth type 1; MS, multiple sclerosis; PBL, peripheral blood lymphocyte; PTSD, post-traumatic stress disorder; RA, rheumatoid arthritis; SARS, severe acute respiratory syndrome; SCID, severe combined immunodeficiency.