Table 3:

Molecular matching among 436 disease signatures and the juvenile plasticity signature indicates diverse diseases may disrupt plasticity

RankNormalized molecular match scoreEmp_pvalFDRSource_datSpeciesDiseaseTissue
19.644.53E-081.22E-05GSE7958Mus musculusHuntington's diseaseCNS, brain, striatum (MMHCC)
28.357.74E-081.22E-05GSE1623Mus musculusType 1 diabetes mellitusPancreas
38.328.58E-073.40E-05GSE9857Mus musculusHuntington's diseaseCNS, brain, striatum (MMHCC)
47.961.38E-071.22E-05GSE4648Mus musculusAcute myocardial infarctionMyocardial tissue
57.591.40E-071.22E-05GSE4290Homo sapiensGlioblastomaCNS, brain (MMHCC)
67.523.36E-072.44E-05GSE1481Homo sapiensAnterior horn cell diseaseCNS, spinal cord (MMHCC)
76.819.04E-081.22E-05GSE2240Homo sapiensAtrial fibrillationMyocardial tissue
86.731.47E-064.94E-05GSE5500Mus musculusCardiac hypertrophyMyocardial tissue
96.478.10E-073.40E-05GSE5389Homo sapiensBipolar disorderfrontal cortex
106.338.15E-073.40E-05GSE5078Mus musculusSenescenceHippocampus
116.251.75E-065.46E-05GSE4764Mus musculusYersinia enterocolitica food poisoningPeyer's patch
125.757.82E-073.40E-05GSE4290Homo sapiensAstrocytomaCNS, brain (MMHCC)
135.71.73E-053.59E-04GSE1621Mus musculusCardiac hypertrophyMyocardial tissue
145.676.55E-057.88E-04GSE3253Mus musculusBacterial infectionCNS, brain (MMHCC)
155.611.16E-064.22E-05GSE10599Mus musculusSpinal muscular atrophyKidney
165.552.49E-067.25E-05GSE3744Homo sapiensBreast cancerMammary gland tissue
175.431.32E-053.04E-04GSE6731Homo sapiensCrohn's diseaseIntestine, large intestine, colon (MMHCC)
185.382.24E-054.24E-04GSE6731Homo sapiensUlcerative colitisIntestine, large intestine, colon (MMHCC)
195.351.29E-053.04E-04GSE11343Mus musculusDiabetic neuropathySciatic nerve
205.357.33E-073.40E-05GSE4316Homo sapiensPrimary open angle glaucomaTrabecular meshwork
215.282.67E-054.65E-04GSE5406Homo sapiensCardiomyopathyMyocardial tissue
225.023.36E-055.29E-04GSE464Rattus norvegicusSpinal cord injuryCNS, spinal cord (MMHCC)
234.981.87E-053.71E-04EXPE-MEXP-567Homo sapiensGlioblastomaBrain
244.941.17E-041.13E-03GSE1025Mus musculusDMDMuscle, striated (skeletal) (MMHCC)
254.95.26E-056.95E-04GSE1843Rattus norvegicusHepatic cirrhosisHepatic tissue
264.861.54E-053.37E-04GSE1572Homo sapiensSenescencefrontal cortex
274.816.87E-057.88E-04GSE1472Mus musculusDMDMuscle, striated (skeletal) (MMHCC)
284.819.47E-062.43E-04GSE2510Homo sapiensObesityAdipocyte
294.83.91E-055.49E-04GSE3383Mus musculusCardiac hypertrophyMyocardial tissue
304.781.06E-041.05E-03GSE1629Homo sapiensDental cavity, complexDental pulp
314.726.79E-057.88E-04GSE2629Mus musculusMuscular dystrophyMuscle, striated (skeletal) (MMHCC)
324.673.90E-055.49E-04GSE4290Homo sapiensOligodendrogliomaCNS, brain (MMHCC)
334.631.71E-041.49E-03GSE10760Homo sapiensMuscular dystrophyMusculus vastus lateralis
344.629.53E-051.01E-03GSE1988Mus musculusCardiac failureMyocardial tissue
354.614.84E-056.59E-04GSE3467Homo sapiensPapillary carcinoma of the thyroidThyroid gland (MMHCC)
364.573.84E-055.49E-04GSE3621Mus musculusHuntington's diseaseBrain
374.563.35E-055.29E-04GSE4107Homo sapiensCancer of colonIntestine, large intestine, colon (MMHCC)
384.541.20E-041.14E-03GSE842Mus musculusMSCNS, spinal cord (MMHCC)
394.538.18E-059.14E-04GSE14905Homo sapiensPsoriasis vulgarisSkin tissue
404.513.40E-055.29E-04GSE7305Homo sapiensEndometriosisEndometrium
414.488.91E-062.43E-04GSE16524Homo sapiensSetleis syndromeSkin fibroblast
424.466.85E-057.88E-04GSE4183Homo sapiensCarcinoma in situ of large intestineColon
434.432.37E-054.30E-04GSE12654Homo sapiensSchizophreniaCerebral cortex
444.31.62E-041.44E-03GSE2866Mus musculusγ-Hydroxybutyric acidemiaCNS, brain, cerebellum (MMHCC)
454.229.23E-051.01E-03GSE1859Mus musculusFDIUHepatic tissue
464.195.52E-057.08E-04GSE4587Homo sapiensMalignant melanomaEpidermis
474.162.13E-041.82E-03GSE63Mus musculusCerebral infarctionCNS, brain (MMHCC)
484.162.26E-041.83E-03GSE6614Mus musculusGeneralized seizuresBrain
494.081.58E-041.44E-03GSE6280Homo sapiensChronic kidney diseaseKidney
504.013.19E-042.44E-03GSE5390Homo sapiensDown’s syndromeBrain
514.012.66E-042.11E-03GSE2052Homo sapiensIdiopathic fibrosing alveolitisLung tissue
5242.23E-041.83E-03GSE1873Mus musculusObstructive sleep apneaHepatic tissue
533.974.39E-043.07E-03GSE4183Homo sapiensIBDColon
543.961.01E-041.02E-03GSE3075Mus musculusSpinal muscular atrophy, infantileCNS, spinal cord (MMHCC)
553.941.42E-041.32E-03GSE3167Homo sapiensUrothelial carcinoma in situUrothelium
563.932.20E-041.83E-03GSE8514Homo sapiensAdenomaAdrenal gland
573.934.01E-042.92E-03GSE6764Homo sapiensCarcinoma, hepatocellularLiver
583.924.89E-043.18E-03GSE3585Homo sapiensCardiomyopathy, dilatedMyocardial tissue
593.893.39E-042.55E-03GSE1420Homo sapiensBarrett esophagusEsophageal tissue
603.889.89E-051.02E-03GSE1420Homo sapiensAdenocarcinoma of esophagusEsophageal tissue
613.874.40E-043.07E-03GSE781Homo sapiensClear cell carcinoma of kidneyRenal tissue
623.875.95E-043.51E-03GSE2528Mus musculusBreast cancerMammary gland
633.849.37E-044.92E-03GSE1026Mus musculusDMDMuscle, striated (skeletal), diaphragm (MMHCC)
643.795.25E-043.35E-03GSE3678Homo sapiensPapillary carcinoma of the thyroidThyroid gland (MMHCC)
653.744.88E-043.18E-03GSE4619Homo sapiensMDSBone marrow stem cell
663.735.92E-043.51E-03GSE3112Homo sapiensPolymyositisMuscle tissue
673.723.51E-042.59E-03GSE3189Homo sapiensMultiple benign melanocytic neviEpidermis
683.685.76E-043.49E-03GSE769Mus musculusCystic fibrosisPancreas
693.665.76E-043.49E-03GSE10432Homo sapiensAcneSebocyte
703.651.30E-036.16E-03GSE3252Mus musculusMuscular dystrophyMuscle, striated (skeletal), diaphragm (MMHCC)
713.624.81E-043.18E-03GSE12649Homo sapiensSchizophreniaCerebral cortex
723.67.41E-044.17E-03GSE2501Mus musculusThymic carcinomaThymus
733.591.20E-035.87E-03GSE3268Homo sapiensSquamous cell carcinoma of lungLung tissue
743.587.82E-044.32E-03GSE857Mus musculusHuntington's diseaseCNS, brain (MMHCC)
753.582.96E-042.30E-03GSE1009Homo sapiensDiabetic nephropathyRenal tissue
763.571.20E-035.87E-03GSE977Mus musculusAlexander diseaseCNS, brain, olfactory bulb (MMHCC)
773.555.37E-043.35E-03GSE2826Mus musculusBruton's agammaglobulinemiaB-cell lymphocyte
783.547.46E-044.17E-03GSE2640Mus musculusPulmonary fibrosisLung tissue
793.535.37E-043.35E-03GSE2514Homo sapiensAdenocarcinoma of lungLung tissue
803.538.90E-044.73E-03GSE1551Homo sapiensDermatomyositisMuscle, striated (skeletal) (MMHCC)
813.524.50E-043.07E-03GSE2507Mus musculusMuscular dystrophyMuscle, striated (skeletal) (MMHCC)
823.57.15E-044.10E-03GSE3189Homo sapiensMalignant melanomaEpidermis
833.51.10E-035.58E-03GSE4764Mus musculusY. enterocolitica food poisoningLymph node
843.458.68E-044.67E-03EXPE-MEXP-567Homo sapiensGlioblastomaBrain
853.434.44E-043.07E-03GSE3408Homo sapiensAtypical mycobacterial infectionmacrophage
863.431.10E-035.58E-03GSE6428Rattus norvegicusType 2 diabetes mellitusEndocrine pancreas, islet cell of Langerhans, β-cell (MMHCC)
873.428.45E-044.61E-03GSE10575Homo sapiensArthropathyChondrocyte
883.46.73E-043.91E-03GSE9375Mus musculusHuntington's diseaseCNS, brain, striatum (MMHCC)
893.392.10E-039.16E-03GSE4390Mus musculusALSCNS, spinal cord (MMHCC)
903.381.21E-035.87E-03GSE3644Mus musculusAcute pancreatitisPancreas
913.381.30E-036.16E-03GSE3112Homo sapiensInclusion body myositidesMuscle tissue
923.331.10E-035.58E-03GSE466Mus musculusDMDMuscle, striated (skeletal) (MMHCC)
933.291.40E-036.36E-03GSE2144Homo sapiensGERDEsophageal tissue
943.271.40E-036.36E-03EXPE-MEXP-1296Mus musculusCancer of prostateProstate
953.241.70E-037.64E-03GSE2724Homo sapiensUterine leiomyomaUterus
963.213.30E-031.30E-02GSE2825Rattus norvegicusIdiosyncratic drug effectHepatic tissue
973.192.60E-031.08E-02GSE1007Homo sapiensDMDMuscle, striated (skeletal) (MMHCC)
983.191.20E-035.87E-03GSE1781Rattus norvegicusSepsisHepatic tissue
993.182.40E-031.03E-02GSE2899Mus musculusType 2 diabetes mellitusAdipose tissue
1003.181.90E-038.37E-03GSE2557Mus musculusKidney disorder associated with type 2 diabetes mellitusMesangial cell
1013.181.40E-036.36E-03GSE3524Homo sapiensSquamous cell carcinoma of mouthOropharynx epithelium
1023.171.40E-036.36E-03GSE13355Homo sapiensPsoriasis vulgarisSkin tissue
1033.152.20E-039.50E-03GSE2866Mus musculusγ-Hydroxybutyric acidemiaCerebral cortex
1043.122.60E-031.08E-02GSE4911Mus musculusCleidocranial dysostosisHumerus
1053.121.90E-038.37E-03GSE24807Homo sapiensNASHLiver
1063.123.20E-031.28E-02GSE10631Homo sapiensLGLLPeripheral blood mononuclear cell
1073.112.70E-031.11E-02GSE2052Homo sapiensSclerodermaLung tissue
1083.072.90E-031.17E-02GSE4692Mus musculusObesityAdipose tissue
1093.052.50E-031.06E-02GSE4824Homo sapiensNon-small cell lung cancerBronchial epithelium
1103.033.80E-031.47E-02GSE1145Homo sapiensIschemic cardiomyopathyMyocardial tissue
1113.014.90E-031.77E-02GSE6678Mus musculusInfantile neuronal ceroid lipofuscinosisBrain
11233.30E-031.30E-02GSE3064Homo sapiensDystoniaBrain
1132.994.70E-031.72E-02GSE2527Mus musculusThrombocytopeniaMegakaryocyte
1142.994.30E-031.62E-02GSE2433Mus musculusLeukemia, acute megakaryocyticMegakaryocyte
1152.934.60E-031.71E-02GSE1776Mus musculusNutritional deficiency, NECSkeletal myocyte
1162.933.90E-031.49E-02GSE4587Homo sapiensIn situ melanoma of skinEpidermis
1172.925.30E-031.88E-02GSE9579Homo sapiensAppendicitisAppendix
1182.915.80E-032.01E-02GSE2411Mus musculusVentilator-associated lung injuryLung tissue
1192.92.80E-031.14E-02GSE1037Homo sapiensSmall cell carcinoma of lungLung tissue
1202.865.20E-031.86E-02GSE2401Rattus norvegicusHypotensive episodeRenal tissue
1212.854.70E-031.72E-02GSE765Mus musculusCystic fibrosisIntestinal epithelium
1222.833.60E-031.40E-02EXPE-MEXP-882Homo sapiensInvasive ductal breast cancerMammary epithelium
1232.836.70E-032.28E-02GSE1869Homo sapiensIschemic cardiomyopathyMyocardial tissue
1242.825.60E-031.95E-02GSE4183Homo sapiensAdenomaColon
1252.825.40E-031.90E-02GSE1004Homo sapiensDMDMuscle, striated (skeletal) (MMHCC)
1262.814.30E-031.62E-02GSE9944Homo sapiensGlaucomaAstrocyte
1272.796.20E-032.13E-02EXPE-TABM-176Homo sapiensIrritable bowel syndrome variant of childhood with diarrheaSigmoid colon
1282.728.40E-032.75E-02GSE2779Homo sapiensMDSBone marrow stem cell
1292.727.20E-032.43E-02GSE1947Mus musculusPeripheral motor neuropathySciatic nerve
1302.718.40E-032.75E-02GSE593Homo sapiensUterine leiomyomaUterus, myometrium (MMHCC)
1312.717.50E-032.52E-02GSE2712Homo sapiensClear cell sarcoma of kidneyRenal tissue
1322.698.50E-032.75E-02GSE1459Mus musculusBacterial InfectionMacrophage
1332.678.50E-032.75E-02GSE1811Mus musculusOccupational lung diseaseLung Tissue
1342.678.90E-032.85E-02GSE2508Homo sapiensObesityAdipocyte
1352.668.10E-032.70E-02GSE1462Homo sapiensMELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes)Muscle, striated (skeletal) (MMHCC)
1362.659.00E-032.86E-02GSE4130Rattus norvegicusDehydrationCNS, brain, hypothalamus (MMHCC)
1372.619.10E-032.88E-02GSE1378Homo sapiensBreast cancerMammary gland tissue
1382.61.14E-023.45E-02GSE1375Mus musculusAlzheimer's diseaseCerebral cortex
1392.599.80E-033.03E-02GSE2719Homo sapiensGastrointestinal stromal tumorConnective tissue
1402.599.60E-033.01E-02GSE7036Homo sapiensBipolar disorderLymphocyte
1412.571.00E-023.07E-02GSE1724Homo sapiensSclerodermaFibroblast
1422.569.70E-033.02E-02GSE3790Homo sapiensHuntington's diseaseCaudate nucleus
1432.551.25E-023.68E-02GSE6764Homo sapiensHepatic cirrhosisLiver
1442.541.24E-023.68E-02GSE2457Rattus norvegicusErectile dysfunction associated with type 2 diabetes mellitusPenis, NOS
1452.541.47E-024.14E-02GSE2457Rattus norvegicusErectile dysfunctionPenis erectile tissue
1462.541.05E-023.20E-02GSE3110Rattus norvegicusDehydrationHypothalamus
1472.531.22E-023.64E-02GSE2712Homo sapiensNephroblastomaRenal tissue
1482.511.42E-024.05E-02GSE7999Rattus norvegicusTachycardiaMyocardial tissue
1492.511.29E-023.77E-02GSE609Homo sapiensSCIDThymic lymphocyte
1502.491.19E-023.58E-02GSE1869Homo sapiensCardiomyopathyMyocardial tissue
1512.491.36E-023.93E-02GSE7621Homo sapiensParkinson's diseaseSubstantia nigra
1522.481.35E-023.92E-02GSE10971Homo sapiensSerous carcinomaFallopian tube
1532.481.40E-024.02E-02GSE3418Mus musculusLung transplant rejectionTrachea
1542.471.45E-024.11E-02EXPE-MEXP-476Homo sapiensCancer of prostateEndothelial cell
1552.471.54E-024.28E-02GSE3184Mus musculusAsthma, allergicLung tissue
1562.461.49E-024.16E-02GSE4616Mus musculusType 1 diabetes mellitusMyocardial tissue
1572.411.68E-024.64E-02GSE4612Mus musculusCarcinoma, hepatocellularHepatic tissue
1582.41.77E-024.85E-02GSE2725Homo sapiensUterine leiomyomaUterus
1592.391.81E-024.90E-02GSE3365Homo sapiensUlcerative colitisPeripheral blood mononuclear cell
1602.371.80E-024.90E-02GSE1813Rattus norvegicusObesityAdipose tissue
1612.361.87E-025.03E-02GSE4060Homo sapiensCushing syndromeAdrenal gland
1622.352.07E-025.50E-02GSE1145Homo sapiensPrimary cardiomyopathyMyocardial tissue
1632.311.88E-025.03E-02GSE6461Mus musculusSynovial sarcomaSynovial membrane
1642.32.15E-025.68E-02GSE1037Homo sapiensNon-small cell lung cancerLung tissue
1652.272.29E-026.01E-02GSE10921Homo sapiensIdiopathic fibrosing alveolitisFibroblast
1662.262.41E-026.28E-02GSE3248Mus musculusHuntington's diseaseCNS, brain, cerebellum (MMHCC)
1672.252.42E-026.28E-02GSE4788Mus musculusParkinson's diseaseSubstantia nigra
1682.242.52E-026.46E-02GSE4710Mus musculusHeart injuryMyocardial tissue
1692.212.52E-026.46E-02GSE6364Homo sapiensEndometriosisEndometrium
1702.22.68E-026.83E-02GSE1462Homo sapiensCPEO (chronic progressive external ophthalmoplegia)Muscle, striated (skeletal) (MMHCC)
1712.193.00E-027.56E-02GSE1724Homo sapiensIdiopathic fibrosing alveolitisFibroblast
1722.182.87E-027.28E-02GSE6955Homo sapiensRett syndromefrontal cortex
1732.133.24E-028.12E-02GSE1017Homo sapiensMyopathy NOSSkeletal muscle
1742.133.39E-028.45E-02GSE2429Homo sapiensBreast cancerMammary gland tissue
1752.123.57E-028.79E-02GSE6764Homo sapiensHepatocellular dysplasiaLiver
1762.113.64E-028.92E-02GSE4516Rattus norvegicusSmoke inhalationLung tissue
1772.13.41E-028.45E-02GSE567Homo sapiensEssential thrombocythemiaMegakaryocyte
1782.093.92E-029.39E-02EXPE-TABM-176Homo sapiensIrritable bowel syndrome variant of childhood with constipationSigmoid colon
1792.083.69E-028.99E-02GSE4130Rattus norvegicusDehydrationPituitary gland
1802.073.72E-029.01E-02GSE9006Homo sapiensType 2 diabetes mellitusPeripheral blood mononuclear cell
1812.064.00E-029.40E-02GSE2899Mus musculusType 2 diabetes mellitusSoleus muscle
1822.064.01E-029.40E-02GSE3125Rattus norvegicusDehydrationHypothalamus
1832.063.99E-029.40E-02GSE3407Homo sapiensCockayne syndromeFibroblast
1842.063.79E-029.13E-02GSE2866Mus musculusγ-Hydroxybutyric acidemiaHippocampus
1852.054.07E-029.49E-02GSE2077Homo sapiensProtozoan InfectionIntestinal epithelium
1862.054.14E-029.60E-02GSE9006Homo sapiensType 1 diabetes mellitusPeripheral blood mononuclear cell
1872.034.01E-029.40E-02GSE10123Homo sapiensPremature agingSkin fibroblast
1882.014.45E-021.01E-01GSE3365Homo sapiensCrohn's diseasePeripheral blood mononuclear cell
1892.014.33E-029.99E-02GSE1297Homo sapiensAlzheimer's diseaseHippocampus
19024.40E-021.01E-01GSE2254Mus musculusType 1 diabetes mellituspancreatic islet
19124.57E-021.03E-01GSE3489Homo sapiensHIV encephalitisfrontal cortex
19224.44E-021.01E-01GSE3203Mus musculusInfluenzaB-cell lymphocyte
1931.994.67E-021.05E-01GSE2559Homo sapiensPulmonary hypertension, primaryPulmonary artery
1941.984.76E-021.06E-01GSE3807Homo sapiensAplastic anemiaBone marrow
1951.984.85E-021.07E-01GSE4105Rattus norvegicusMyocardial infarctionMyocardial tissue
1961.964.72E-021.06E-01GSE4479Mus musculusSepsisSplenocyte
1971.955.26E-021.15E-01GSE3676Mus musculusInfertility due to azoospermiaTesticular tissue
1981.945.21E-021.15E-01GSE10064Homo sapiensMSB-cell lymphocyte
1991.935.48E-021.17E-01GSE5090Homo sapiensPolycystic ovary syndromeAdipose tissue
2001.935.43E-021.17E-01GSE11Mus musculusType 1 diabetes mellitusThymic epithelial cell
2011.925.28E-021.15E-01GSE582Mus musculusTransplanted heart complicationMyocardial tissue
2021.925.44E-021.17E-01GSE10586Homo sapiensType 1 diabetes mellitusT lymphocyte
2031.925.77E-021.21E-01GSE2049Homo sapiensAMLHaematopoietic stem cell
2041.915.56E-021.18E-01GSE11208Homo sapiensNicotine addictionGanglioneuroblastoma
2051.915.61E-021.18E-01GSE5538Mus musculusHepatic lipidosisHepatic Tissue
2061.95.37E-021.16E-01EXPE-MEXP-692Homo sapiensBarrett esophagusEsophagus
2071.95.60E-021.18E-01GSE1659Mus musculusType 1 diabetes mellitusMuscle, striated (skeletal) (MMHCC)
2081.896.00E-021.25E-01GSE4170Homo sapiensCMLHaematopoietic stem cell
2091.886.33E-021.31E-01EXPE-MEXP-692Homo sapiensAdenocarcinoma of esophagusEsophagus
2101.866.21E-021.29E-01GSE422Mus musculusCarcinoma in situ of small intestineIntestinal epithelium
2111.826.93E-021.41E-01GSE1822Homo sapiensEwing's sarcomaRenal tissue
2121.816.69E-021.37E-01GSE755Homo sapiensOsteolysisLeukocyte, lymphocyte, B lymphocyte, plasma cell (MMHCC)
2131.816.60E-021.36E-01GSE3004Homo sapiensAsthma, allergicBronchial epithelium
2141.787.26E-021.47E-01GSE4060Homo sapiensACTH-dependent Cushing syndromeAdrenal gland
2151.767.71E-021.54E-01GSE4120Mus musculusArrhythmogenic right ventricular cardiomyopathyMyocardial tissue
2161.768.01E-021.59E-01GSE3790Homo sapiensHuntington's diseasefrontal cortex
2171.767.70E-021.54E-01GSE9800Homo sapiensCardiomyopathy, dilatedMyocardial tissue
2181.718.68E-021.70E-01GSE3915Mus musculusCancer of the intestineSmall bowel
2191.699.30E-021.80E-01GSE5581Mus musculusRetinoschisisRetina
2201.688.96E-021.75E-01GSE868Mus musculusFamilial hypophosphatemic ricketsRenal tissue
2211.688.99E-021.75E-01EXPE-TABM-176Homo sapiensIBSSigmoid colon
2221.669.61E-021.85E-01GSE6965Homo sapiensInfection by Aspergillus fumigatusDendritic cell
2231.669.71E-021.87E-01GSE6012Homo sapiensEczemaIntegument
2241.659.80E-021.87E-01GSE3554Mus musculusGlaucomaRetina
2251.651.00E-011.90E-01GSE2223Homo sapiensGlioblastomaCNS, brain (MMHCC)
2261.639.98E-021.90E-01EXPE-TABM-26Homo sapiensCancer of prostateProstate
2271.621.03E-011.94E-01GSE4172Homo sapiensViral cardiomyopathyMyocardial tissue
2281.61.08E-012.01E-01GSE2191Homo sapiensAMLMononuclear leukocyte
2291.61.08E-012.01E-01GSE2155Homo sapiensBreast cancerEpithelial cell
2301.561.18E-012.16E-01GSE1299Homo sapiensBreast cancerMammary epithelium
2311.551.15E-012.13E-01GSE3320Homo sapiensCOPDBronchial epithelium
2321.551.19E-012.17E-01GSE5774Homo sapiensNonspecific interstitial pneumoniaLung tissue
2331.551.18E-012.16E-01GSE6710Homo sapiensPsoriasis vulgarisSkin tissue
2341.531.29E-012.31E-01GSE4250Homo sapiensHereditary gingival fibromatosisGingiva
2351.531.24E-012.25E-01GSE5364Homo sapiensCancer of thyroidThyroid
2361.531.18E-012.16E-01GSE3583Mus musculusHuntington's diseaseCNS, brain, striatum (MMHCC)
2371.521.30E-012.32E-01GSE12654Homo sapiensBipolar disorderCerebral cortex
2381.521.29E-012.31E-01GSE973Homo sapiensFunisitisUmbilical blood
2391.511.32E-012.34E-01GSE12649Homo sapiensBipolar disorderCerebral cortex
2401.51.33E-012.35E-01GSE925Rattus norvegicusCardiac hypertrophyCardiomyocyte
2411.481.38E-012.42E-01GSE3544Mus musculusMODYPancreatic islet
2421.471.42E-012.46E-01GSE420Homo sapiensAtherosclerosisAorta smooth muscle tissue
2431.471.37E-012.42E-01GSE422Mus musculusAdenoma of small intestineIntestinal epithelium
2441.461.41E-012.46E-01EXPE-TABM-36Homo sapiensHepatocellular adenomaHepatocyte
2451.451.38E-012.42E-01GSE4302Homo sapiensAsthmaEpithelial cell
2461.451.44E-012.50E-01GSE5370Homo sapiensDermatomyositisMuscle, striated (skeletal) (MMHCC)
2471.421.53E-012.61E-01GSE2172Mus musculusColitisIntestine, large intestine, colon (MMHCC)
2481.411.55E-012.63E-01GSE11750Homo sapiensSenescenceMuscle, striated (skeletal) (MMHCC)
2491.411.56E-012.63E-01GSE3Homo sapiensChromophobe cell carcinoma of kidneyRenal cell
2501.411.52E-012.61E-01GSE2705Homo sapiensPrimary open angle glaucomaOptic disk
2511.371.68E-012.80E-01GSE3860Homo sapiensProgeriaFibroblast
2521.371.73E-012.86E-01GSE674Homo sapiensSenescenceMuscle, striated (skeletal) (MMHCC)
2531.361.72E-012.84E-01GSE2549Homo sapiensMalignant mesothelioma of pleuraPleura
2541.361.71E-012.84E-01GSE1466Homo sapiensLymphoblastic leukemiaT lymphocyte
2551.331.82E-012.97E-01GSE1611Mus musculusDown syndromeCNS, brain, cerebellum (MMHCC)
2561.331.79E-012.93E-01GSE997Homo sapiensEssential thrombocythemiaMegakaryocyte
2571.321.91E-013.09E-01GSE6798Homo sapiensPolycystic ovary syndromeSkeletal muscle
2581.321.83E-012.98E-01GSE3790Homo sapiensHuntington's diseaseCNS, brain, cerebellum (MMHCC)
2591.311.87E-013.03E-01GSE2503Homo sapiensActinic keratosisSkin tissue
2601.291.94E-013.12E-01GSE1010Homo sapiensFamilial combined hyperlipidemiaLymphoblast
2611.272.00E-013.17E-01GSE1028Homo sapiensScott syndromeB-cell lymphocyte
2621.271.98E-013.16E-01GSE5388Homo sapiensBipolar disorderFrontal cortex
2631.272.00E-013.17E-01GSE2067Homo sapiensHepatitis C infectionHepatocyte
2641.262.04E-013.22E-01GSE3280Homo sapiensAcute monocytic leukemiaBlood monocyte
2651.262.07E-013.24E-01GSE642Mus musculusType 2 diabetes mellitusRenal tissue
2661.262.07E-013.24E-01GSE5281Homo sapiensAlzheimer's diseaseSuperior frontal gyrus
2671.212.28E-013.54E-01GSE11348Homo sapiensRhinovirus infectionNose
2681.22.34E-013.61E-01GSE7486Homo sapiensEpilepsyLymphoblast
2691.162.46E-013.74E-01GSE3384Mus musculusNemaline myopathyTibialis Muscle
2701.162.45E-013.73E-01GSE473Homo sapiensAsthmaCD4-positive lymphocyte
2711.162.45E-013.73E-01GSE474Homo sapiensObesityMuscle, striated (skeletal) (MMHCC)
2721.142.50E-013.78E-01EXPE-MEXP-669NULLNeuroblastomaAdrenal cortex
2731.122.62E-013.95E-01GSE3889Mus musculusHypercholesterolemiaHepatic tissue
2741.112.66E-013.97E-01GSE2175Homo sapiensAdenoma of pituitary glandPituitary gland
2751.12.71E-014.03E-01GSE3925Mus musculusHyperreactive airway diseaseLung tissue
2761.092.79E-014.13E-01GSE10162Mus musculusNephrolithiasisKidney
2771.092.62E-013.95E-01GSE2470Rattus norvegicusType 2 diabetes mellitusPancreas
2781.082.77E-014.10E-01GSE362Homo sapiensSenescenceMuscle, striated (skeletal) (MMHCC)
2791.062.87E-014.23E-01GSE2973Mus musculusInfection by Y. enterocoliticaMacrophage
2801.042.98E-014.35E-01GSE4785Homo sapiensSimian acquired immune deficiency syndromeT lymphocyte
2811.042.97E-014.35E-01GSE923Homo sapiensPseudomonas infectionLung tissue
2821.023.07E-014.46E-01GSE12654Homo sapiensDepressionCerebral cortex
2831.013.08E-014.47E-01GSE2053Homo sapiensRASynovial membrane
2841.013.14E-014.54E-01GSE1037Homo sapiensAdenocarcinoma of lungLung tissue
28513.18E-014.58E-01GSE4333Mus musculusLymphatic edemaSkin tissue
2860.993.22E-014.62E-01GSE10964Mus musculusCOPDLung
2870.993.28E-014.69E-01GSE2657Homo sapiensSarcoidosisT lymphocyte
2880.963.41E-014.81E-01GSE1767Homo sapiensHuntington's diseaseBlood
2890.963.35E-014.77E-01GSE7753Homo sapiensJRAPeripheral blood mononuclear cell
2900.953.40E-014.81E-01GSE4125Homo sapiensAdenocarcinoma of kidneyKidney
2910.943.46E-014.87E-01GSE8762Homo sapiensHuntington's diseaseLymphocyte
2920.933.48E-014.88E-01GSE5788Homo sapiensLeukemia, chronic T cellT lymphocyte
2930.923.56E-014.98E-01GSE483Mus musculusAsthma, allergicLung tissue
2940.913.58E-014.99E-01GSE2566Rattus norvegicusNeurogenic muscular atrophyMuscle, striated (skeletal) (MMHCC)
2950.913.60E-014.99E-01GSE2600Homo sapiensAnaplasmosisLeukemic cell
2960.913.68E-015.06E-01GSE2127Mus musculusCarcinoma, hepatocellularHepatic tissue
2970.913.59E-014.99E-01GSE2052Homo sapiensMCTDLung tissue
2980.843.85E-015.26E-01GSE2276Mus musculusAsthma, allergicLung tissue
2990.844.07E-015.52E-01GSE4707Homo sapiensPreeclampsiaPlacenta
3000.814.22E-015.68E-01GSE3871Homo sapiensAndrogen insensitivity syndromeFibroblast
3010.814.17E-015.63E-01GSE1606Mus musculusTurner syndromeCNS, brain (MMHCC)
3020.84.27E-015.70E-01GSE1674Mus musculusHypertensionAdrenal gland
3030.84.28E-015.70E-01GSE3195Mus musculusHypoxiaFibroblast
3040.794.28E-015.70E-01GSE475Homo sapiensCOPDMuscle, striated (skeletal), diaphragm (MMHCC)
3050.794.34E-015.75E-01GSE1872Rattus norvegicusBreast cancerMammary gland tissue
3060.794.29E-015.70E-01GSE3868Homo sapiensCancer of prostateProstate
3070.764.46E-015.87E-01EXPE-MEXP-669NULLNeuroblastomaAdrenal cortex
3080.764.43E-015.85E-01GSE5109Homo sapiensObesityMuscle, striated (skeletal) (MMHCC)
3090.734.64E-016.07E-01GSE1413Mus musculusCancer of prostateProstate
3100.724.76E-016.18E-01GSE5281Homo sapiensAlzheimer's DiseaseMiddle temporal gyrus
3110.724.71E-016.15E-01GSE3384Mus musculusNemaline myopathyExtensor digitorum longus muscle
3120.694.89E-016.32E-01GSE2223Homo sapiensAstrocytomaCNS, brain (MMHCC)
3130.684.97E-016.42E-01EXPE-MEXP-476Homo sapiensCancer of prostateEndothelial cell
3140.684.99E-016.42E-01EXPE-MEXP-476Homo sapiensCancer of prostateEndothelial cell
3150.665.10E-016.54E-01GSE9877Homo sapiensSickle cell anemiaEndothelial cell
3160.655.18E-016.62E-01GSE3026Homo sapiensBacterial infectionPeripheral blood mononuclear cell
3170.635.30E-016.76E-01GSE128Mus musculusRetinitis pigmentosaRetina
3180.615.34E-016.77E-01GSE1379Homo sapiensBreast cancerMammary gland tissue
3190.585.63E-017.02E-01GSE867Mus musculusHepatitis, autoimmuneHepatic tissue
3200.585.63E-017.02E-01GSE465Homo sapiensDMDMuscle, striated (skeletal) (MMHCC)
3210.585.61E-017.02E-01GSE1871Mus musculusAcute lung injuryLung tissue
3220.575.65E-017.02E-01GSE5900Homo sapiensMGUSBone marrow
3230.575.70E-017.02E-01GSE2223Homo sapiensOligodendrogliomaCNS, brain (MMHCC)
3240.575.65E-017.02E-01GSE1055Rattus norvegicusCardiac hypertrophyCardiomyocyte
3250.575.70E-017.02E-01GSE4748Homo sapiensBacterial infectionDendritic cell
3260.575.73E-017.03E-01GSE3384Mus musculusNemaline myopathyMuscle, striated (skeletal), diaphragm (MMHCC)
3270.575.70E-017.02E-01GSE2236Mus musculusCongestive heart diseaseMyocardial tissue
3280.565.74E-017.03E-01GSE1008Mus musculusDMDExtraocular muscle
3290.535.90E-017.15E-01GSE1472Mus musculusDMDExtraocular muscle
3300.536.02E-017.20E-01GSE85Mus musculusAPECEDThymic epithelial cell
3310.535.92E-017.15E-01GSE1849Homo sapiensSickle cell anemiaPulmonary artery
3320.525.99E-017.19E-01GSE3311Rattus norvegicusAlcohol poisoningPancreas
3330.516.03E-017.21E-01GSE2503Homo sapiensSquamous cell carcinomaSkin tissue
3340.56.17E-017.35E-01GSE2899Mus musculusType 2 diabetes mellitusHepatic tissue
3350.486.26E-017.42E-01GSE1739Homo sapiensSARSPeripheral blood mononuclear cell
3360.466.46E-017.57E-01GSE5900Homo sapiensSmoldering multiple myelomaBone marrow
3370.456.64E-017.74E-01GSE4678Mus musculusVentricular hypertrophyMyocardial tissue
3380.436.63E-017.74E-01GSE4128Mus musculusAdenovirus infectionHepatic tissue
3390.426.79E-017.81E-01GSE11889Homo sapiensCMLHematopoietic stem cell
3400.426.72E-017.79E-01GSE2779Homo sapiensVitamin B 12 deficiencyBone marrow stem cell
3410.46.89E-017.90E-01GSE3Homo sapiensClear cell carcinoma of kidneyRenal cell
3420.387.02E-017.97E-01GSE9692Homo sapiensSeptic shockWhole blood
3430.387.10E-018.01E-01GSE6740Homo sapiensHIVT lymphocyte
3440.367.13E-018.03E-01GSE121Homo sapiensType 2 diabetes mellitusMuscle tissue
3450.367.25E-018.14E-01GSE1402Homo sapiensSpondyloarthropathyPeripheral blood mononuclear cell
3460.347.34E-018.20E-01GSE2271Mus musculusHypoxiaHeart
3470.347.40E-018.21E-01GSE2466Homo sapiensLymphocytic leukemia, chronic, B CellPBL
3480.347.37E-018.21E-01GSE1751Homo sapiensHuntington's diseaseBlood
3490.287.76E-018.48E-01GSE10211Mus musculusSendai virus infectionTracheal epithelium
3500.277.86E-018.57E-01GSE2379Homo sapiensHypopharyngeal cancerPharynx
3510.258.01E-018.70E-01GSE2884Rattus norvegicusNeurological pain disorderDorsal root ganglia
3520.248.02E-018.70E-01GSE1560Mus musculusAtherosclerosisAorta smooth muscle tissue
3530.198.51E-019.11E-01GSE18803Rattus norvegicusNeurological pain disorderCNS, spinal cord (MMHCC)
3540.178.63E-019.18E-01GSE1124Homo sapiensMalariaBlood
3550.178.69E-019.19E-01EXPE-MEXP-1050Homo sapiensIUGRDecidua basalis
3560.158.82E-019.28E-01GSE4697Mus musculusObesityAdipose tissue
3570.129.02E-019.43E-01GSE3249Mus musculusLeber congenital amaurosisRetina
3580.129.02E-019.43E-01GSE1852Mus musculusMarfan’s syndromeMyocardial tissue
3590.089.34E-019.66E-01GSE7654Rattus norvegicusHepatitisLiver
3600.089.35E-019.66E-01GSE2504Homo sapiensHIVT lymphocyte
3610.089.39E-019.66E-01GSE1710Homo sapiensUlcerative colitisSigmoid colon
3620.089.40E-019.66E-01GSE3167Homo sapiensUrothelial carcinomaUrothelium
3630.079.45E-019.66E-01GSE5281Homo sapiensAlzheimer's diseaseEntorhinal cortex
3640.079.46E-019.66E-01GSE3586Homo sapiensCardiomyopathy, dilatedMyocardial tissue
3650.049.70E-019.88E-01GSE10758Homo sapiensDown syndromeFetus
3660.029.82E-019.89E-01GSE15966Homo sapiensGastrointestinal stromal tumorGastric tissue
3670.019.94E-019.96E-01GSE11969Homo sapiensSmall cell carcinoma of lungLung tissue
36809.98E-019.98E-01GSE4482Homo sapiensCancer of cervixCervix
369−0.019.93E-019.96E-01GSE11393Homo sapiensFamilial combined hyperlipidemiaBlood monocyte
370−0.029.81E-019.89E-01GSE10474Homo sapiensAcute lung injuryWhole blood
371−0.029.81E-019.89E-01GSE574Homo sapiensPurpura, idiopathic thrombocytopenicT lymphocyte
372−0.029.80E-019.89E-01GSE3827Homo sapiensCBCLSkin tissue
373−0.039.76E-019.89E-01GSE8835Homo sapiensB-cell chronic lymphocytic leukemia/small lymphocytic lymphomaPeripheral blood mononuclear cell
374−0.079.42E-019.66E-01GSE2779Homo sapiensFolic acid deficiencyBone marrow stem cell
375−0.19.19E-019.54E-01GSE860Homo sapiensPTSDPeripheral blood mononuclear cell
376−0.119.18E-019.54E-01GSE2935Mus musculusSendai virus infectionMacrophage
377−0.119.15E-019.54E-01GSE4483Homo sapiensHypoxiaAstrocyte
378−0.148.89E-019.34E-01GSE1650Homo sapiensCOPDLung tissue
379−0.168.74E-019.23E-01EXPE-MEXP-1278Rattus norvegicusArteriotomyCarotid artery
380−0.178.68E-019.19E-01GSE1541Homo sapiensLung injuryLung tissue
381−0.188.52E-019.11E-01GSE2899Mus musculusType 2 diabetes mellituspancreatic islet
382−0.198.55E-019.12E-01GSE935Homo sapiensGranulomatous disease, chronicBlood neutrophil
383−0.198.42E-019.06E-01GSE2171Homo sapiensHIV infectionPeripheral blood mononuclear cell
384−0.28.46E-019.08E-01GSE4036Homo sapiensSchizophreniaCNS, brain, cerebellum (MMHCC)
385−0.228.27E-018.93E-01GSE14245Homo sapiensMalignant tumor of pancreasSaliva
386−0.248.06E-018.72E-01GSE2459Mus musculusHypertrophy, left ventricularMyocardial tissue
387−0.297.69E-018.44E-01GSE1818Homo sapiensCancer of the testisTestis
388−0.297.71E-018.44E-01GSE10789Homo sapiensLeukemia, adult T cellBlood monocyte
389−0.37.66E-018.43E-01GSE2368Mus musculusVentilator-associated lung injuryLung tissue
390−0.327.59E-018.38E-01GSE11Mus musculusType 1 diabetes mellitusSplenic tissue
391−0.327.44E-018.24E-01GSE2507Mus musculusMuscular dystrophyMyocardial tissue
392−0.347.39E-018.21E-01GSE11969Homo sapiensAdenocarcinoma of lungLung tissue
393−0.347.29E-018.17E-01GSE3Homo sapiensChromophil carcinoma of kidneyRenal cell
394−0.377.05E-017.99E-01GSE1710Homo sapiensCrohn's diseaseSigmoid colon
395−0.386.97E-017.93E-01GSE1987Homo sapiensSquamous cell carcinomaLung tissue
396−0.46.96E-017.93E-01GSE1719Homo sapiensMacular degenerationFibroblast
397−0.46.91E-017.90E-01GSE2737Homo sapiensPsoriasis vulgarisEpidermis
398−0.416.78E-017.81E-01GSE2729Homo sapiensRotavirus infection of childrenPeripheral blood mononuclear cell
399−0.416.78E-017.81E-01GSE14577Homo sapiensCFSPeripheral blood mononuclear cell
400−0.436.66E-017.74E-01GSE363Mus musculusAtherosclerosisHepatic tissue
401−0.466.46E-017.57E-01GSE1987Homo sapiensAdenocarcinoma of lungLung tissue
402−0.476.42E-017.57E-01GSE1786Homo sapiensSenescenceMuscle, striated (skeletal) (MMHCC)
403−0.476.33E-017.48E-01GSE2018Homo sapiensLung transplant rejectionLung tissue
404−0.496.26E-017.42E-01GSE5113Mus musculusIntestinal flagellate infectionSmall intestinal lamina propria
405−0.525.99E-017.19E-01GSE4646Homo sapiensMeningococcal infectionUmbilical vein
406−0.545.89E-017.15E-01GSE3934Homo sapiensMeningococcal infectionBlood
407−0.545.86E-017.13E-01GSE11969Homo sapiensSquamous cell carcinoma of lungLung tissue
408−0.555.80E-017.08E-01GSE3606Homo sapiensOverexertionLeukocyte
409−0.595.55E-016.99E-01GSE2378Homo sapiensGlaucomaAstrocyte
410−0.615.43E-016.86E-01GSE11969Homo sapiensLarge cell carcinoma of lungLung tissue
411−0.635.34E-016.77E-01GSE1907Homo sapiensSarcoidosisBlood corpuscle
412−0.74.74E-016.17E-01GSE3100Mus musculusCystic fibrosisLung
413−0.744.62E-016.07E-01GSE7277Mus musculusArthritisfrontal cortex
414−0.853.97E-015.39E-01GSE3384Mus musculusNemaline myopathyGastrocnemius muscle
415−0.853.95E-015.38E-01GSE1363Mus musculusPrimary pulmonary hypoplasiaLung tissue
416−0.863.85E-015.26E-01GSE11886Homo sapiensAnkylosing spondylitismacrophage
417−0.93.66E-015.05E-01GSE1542Homo sapiensDuct cell carcinomaPancreas
418−0.943.40E-014.81E-01GSE3414Mus musculusSCIDLung tissue
419−1.042.98E-014.35E-01GSE2223Homo sapiensAnaplastic oligoastrocytomaCNS, brain (MMHCC)
420−1.112.66E-013.97E-01GSE1615Homo sapiensPolycystic ovary syndromeTheca cells
421−1.172.41E-013.70E-01GSE1402Homo sapiensChronic polyarticular juvenile rheumatoid arthritisPeripheral blood mononuclear cell
422−1.182.37E-013.65E-01GSE5786Mus musculusHuntington's diseaseCNS, brain, striatum (MMHCC)
423−1.232.19E-013.42E-01GSE3284Homo sapiensBacterial infectionLeukocyte
424−1.282.01E-013.18E-01GSE3512Rattus norvegicusHyperlipidemiaHepatic tissue
425−1.291.97E-013.16E-01EXPE-MEXP-357Rattus norvegicusHypertensionLeft ventricle
426−1.361.75E-012.88E-01GSE4630Homo sapiensHypoxiamacrophage
427−1.381.68E-012.80E-01GSE1294Mus musculusDown’s syndromeCNS, brain (MMHCC)
428−1.391.61E-012.70E-01GSE5112Mus musculusIntestinal flagellate infectionIntestinal epithelium
429−1.421.53E-012.61E-01GSE2006Homo sapiensEssential thrombocythemiaThrombocyte
430−1.441.46E-012.52E-01GSE1402Homo sapiensPauciarticular juvenile arthritisPeripheral blood mononuclear cell
431−1.541.24E-012.25E-01EXPE-MEXP-1283Homo sapiensHodgkin’s lymphomaPeripheral blood mononuclear cell
432−1.631.03E-011.94E-01GSE1919Homo sapiensRASynovial membrane
433−1.738.56E-021.69E-01GSE2395Homo sapiensCystic fibrosisBronchial epithelium
434−1.748.09E-021.60E-01GSE6435Mus musculusBacterial infectionLeukocyte, monocyte, macrophage (MMHCC)
435−1.767.44E-021.50E-01GSE1919Homo sapiensOsteoarthritisSynovial membrane
436−2.774.80E-031.74E-02GSE10121Homo sapiensSquamous cell carcinoma of buccal mucosaBuccal mucosa
  • We computationally matched the juvenile plasticity signature to 436 disease signatures derived from public microarray data. This systematic method applies a rank-based molecular matching algorithm to determine the molecular concordance between the plasticity signature and a given disease signature, where high scores indicate that plasticity genes are significantly dysregulated by the disease and low scores indicate that the disease has no impact on plasticity genes. Highly ranked diseases included not only brain disorders known to disrupt plasticity such as Huntington’s disease, but also non-neurologic disorders (e.g., bacterial infections, inflammatory bowel disease, metabolic diseases), suggesting that a broad range of disease states may impact molecular pathways involved in plasticity. ALS, Amyotrophic lateral sclerosis; AML, acute myeloid leukemia; APECED, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy; CBCL, cutaneous B-cell lymphoma; CFS, chronic fatigue syndrome; CML, chronic myeloid leukemia; COPD, chronic obstructive pulmonary disease; DMD, Duchenne muscular dystrophy; FDIU, fetal death in utero; FDR, false discovery rate; GERD, gastroesophageal reflux disease; HIV, human immunodeficiency virus; IBD, inflammatory bowel disease; IBS, irritable bowel syndrome; IUGR, intrauterine growth retardation; JRA, juvenile rheumatoid arthritis; LGLL, large granular lymphocytic leukemia; MCTD, mixed connective tissue disease; MDS, myelodysplastic syndrome; MGUS, Monoclonal gammopathy of undetermined significance; MMHCC, Mouse Models of Human Cancers Consortium; MODY, maturity onset diabetes in youth type 1; MS, multiple sclerosis; PBL, peripheral blood lymphocyte; PTSD, post-traumatic stress disorder; RA, rheumatoid arthritis; SARS, severe acute respiratory syndrome; SCID, severe combined immunodeficiency.