Table 1.

Intrinsic ion channels and electrical coupling components in model and their maximal conductance parameter’s ceiling value

NameChannelg (S/m2)
NaFast sodium3500
PPersistent sodium9.5
CaSSlow calcium0.5
K1/K2Delayed-rectifier potassium25 (soma), 375 (neurites), 500 (axon)
KAA-type potassium50 (neurites), 750 (axon)
KCaCalcium-dependent potassium50
synESynaptic coupling10 [nS]
  • MOEA algorithm optimized parameters between 2% and 100% of these values at 2% increments.