Table 3.

Representative genes that are differentially expressed in ipsi- and contralateral RGCs.

FunctionGene symbolGene nameFold changep-value
High in ipsilateral RGCs
    Regulation of transcriptionAtoh7Atonal homolog 7 (Math5)3.870.010
Gli3GLI-Kruppel family member GLI33.190.015
Klf4Kruppel-like factor 47.380.002
Lhx2LIM homeobox protein 24.720.009
Neurod4Neurogenic differentiation 46.000.013
Otx2Orthodenticle homolog 25.020.021
Sox2SRY-box containing gene 27.470.029
Sox9SRY-box containing gene 95.690.003
Zic1Zinc finger protein of the cerebellum 15.670.002
Zic2Zinc finger protein of the cerebellum 25.780.016
    Developmental signalingFzd5Frizzled homolog 55.040.024
Notch2Notch gene homolog 26.020.031
Tgfb2Transforming growth factor, beta 26.360.005
    Axon guidanceSema5bSemaphorin 5B4.110.007
    Cell cycle controlCcnd2Cyclin D28.170.002
    Other cellular functionsGja1Gap junction protein, alpha 1 (connexin 43)17.600.001
Slc1a3Glial high affinity glutamate transporter9.470.002
Slc2a1Facilitated glucose transporter3.190.016
Slc6a4Serotonin transporter (Sert)4.490.004
SparcSecreted acidic cysteine rich glycoprotein12.470.000
High in contralateral RGCs
    Regulation of transcriptionPou4f1POU domain, class 4, transcription factor 1 (Brn3a)2.200.001
Tbx20T-box 202.150.001
    SignalingBmperBMP-binding endothelial regulator2.830.002
    Axon guidanceSema3eSemaphorin 3E2.200.003
Sema7aSemaphorin 7A2.030.022
  • Genes previously known to be differentially expressed in ipsilateral and contralateral RGCs are bolded (Zic2, SERT, Brn3a).