Table 5.

List of genes whose expression level is significantly altered by lithium treatment in Shu mutants.^{^a}

Gene symbol	Cytogenetic location	Fold change	p-value^b	Function^c
List	55E10	↑7.11	0.0001	Sodium:neurotransmitter symporter
CG5999	87C8	↑6.55	0.0462	UDP-glucosyltransferase activity
Arc1	50F6	↑4.67	0.0002	Stress response
CG7763	47F11	↑3.25	5.3 × 10⁻⁶	C-type lectin
MtnD	92F1	↑3.14	0.0445	Metal homeostasis
Nmdmc	85C3	↑2.92	0.0033	NAD-dependent methylenetetrahydrofolate dehydrogenase activity
CG1673	11F1	↑2.90	0.0026	Branched-chain amino-acid aminotransferase activity
Bin1	89B7	↑2.74	0.0126	Histone deacetylase complex
Hsp22	67B2	↑2.59	0.0003	Response to oxidative stress
Lsp1γ	61A6	↑2.42	0.0094	Nutrient reservoir activity
Cyp309a1	22F4-23A1	↑2.29	0.0034	Cytochrome P450; oxidation-reduction process
CG11425	79E4	↑2.28	0.0055	hydrolase
CG15784	4F10	↑2.26	0.0014	Unknown
Blos2	36C11	↑2.19	0.0415	Biogenesis of lysosome-related organelles
NimC2	34E5	↑2.17	0.0162	Phagocytosis
Cpr64Ac	64A10	↑2.15	0.0023	Cuticular protein
Ahcy13	13C3	↑2.14	0.0001	Adenosylhomocysteinase activity
CG34136	39A1	↑2.07	0.0137	Unknown
AOX1	88F7	↑2.06	0.0042	Aldehyde oxidase activity
Ama	84A5	↑2.04	0.0126	Axon pathfinding
dhd	4F4	↓6.33	0.0156	Thioredoxin
DptB	55F8	↓4.44	0.0487	Defense response (antibacterial peptide)
Mtk	52A1	↓2.85	0.0371	Defense response (antimicrobial peptide)
CG7227	28D3	↓2.46	0.0235	Defense response (scavenger receptor activity)
CG5653	66E5	↓2.18	0.0083	Amine oxidase activity

↵ ^aGenes that were detected on all three chips for RNA samples of Shu with or without lithium treatment and differentially regulated under these conditions with a fold change >2 and p < 0.05. Gene ranking is based on amount of fold change. ^bDetermined by Welch’s t-test (see Materials and Methods). ^cBased on FlyBase.