Table 1.

Identified genes required for DNA damage–induced neural cell death

Category and gene symbolFull gene nameGenBank accession no.ControlMNNGLog2 ratio
Cell death
    DeddDeath effector domain-containingAK00681493798423.39
    Eif2ak2Eukaryotic translation initiation factor 2 alpha kinase 2BE9111443787911.35
    FaslFas ligand (TNF superfamily, member 6)NM_01017730433953.48
    Trim39Tripartite motif-containing 39NM_02446848045113.23
    CCR3Chemokine (C-C motif) receptor 3NM_00991477044742.54
    NME1Non-metastatic cells 1, protein (NM23A) expressed inAV1566409417104.19
    GAS6Growth arrest-specific 6NM_0195214779310.93
    VAMP3Vesicle-associated membrane protein 3BE99414457870373.61
    NCOA1Nuclear receptor coactivator 1BE996469124297872.98
    IFI202BInterferon activated gene 202BAV22914334312,0475.13
    STAT3Signal transducer and activator of transcription 3AK00408390751562.51
    ABCE1ATP-binding cassette, sub-family E, member 1BG06330334424802.85
    CAPN2Calpain 2, (m/II) large subunitNM_009794162513,9813.10
    Map3k12Mitogen activated protein kinase kinase kinase 12BB370469110699.92
Signal transduction
    Sgsm1Small G protein signaling modulator 1AK0107561150378.84
    Grm7Glutamate receptor, metabotropic 7BB5394042147237.81
    V1ra5Vomeronasal 1 receptor, A5NM_05322022535423.98
    Tbc1d8bTBC1 domain family, member 8BAK014817184111,7842.68
    Fgf23Fibroblast growth factor 23AF263536134414,0773.39
Regulation of transcription
    Pcgf6Polycomb group ring finger 6BC01619510016504.04
    Bnc1Basonuclin 1U8806420027083.76
    Zbtb46Zinc finger and BTB domain containing 46AK0167009112203.74
    Med30Mediator complex subunit 30NM_02721231218182.54
    E2f5E2F transcription factor 5BC00322024325473.39
    Myt1Myelin transcription factor 1NM_00866566162873.25
    1300003B13RikRIKEN cDNA 1300003B13 geneAK00487016114273.15
    Snap91Synaptosomal-associated protein 91BG0681321209211.3
    Ccnl1Cyclin L1BB5435561234711.2
Protein kinase activity
    Stk25Serine/threonine kinase 25 (yeast; Stk25)BG0689511149910.55
    Gucy2eGuanylate cyclase 2eNM_008192121111,5633.26
    Tcp10cT-complex protein-10 completeAV25729278449042.65
    Stk22aSerine/threonine kinase 22ANM_0094351196610.94
Oxidoreductase activity
    Mosc2MOCO sulfurase C-terminal domain containing 2NM_1336841152838.91
    Cyp2c65Cytochrome P450, family 2, subfamily c, polypeptide 65AK00868828348014.08
Hydrolase activity
    Fbp2Fructose bisphosphatase 2NM_0079943535110.80
    Pgam5Phosphoglycerate mutase family member 5BC021317415338.58
    Orc4lOrigin recognition complex, subunit 4-likeBB6207042718776.12
    Mtm1X-linked myotubular myopathy gene 1NM_019926139513,9123.32
Ubiquitin-protein ligase activity
    March1Membrane-associated ring finger (C3HC4) 1AK0135821491512.26
Transporter
    Ubl7Ubiquitin-like 7 (bone marrow stromal cell-derived)BC0164561115137.1
    Sec15l1SEC15-like 1 (S. cerevisiae)BC02685947128552.6
    Clic5Chloride intracellular channel 5BB0285012518056.17
    Slc8a1Solute carrier family 8, member 1BM12350854868503.64
    Clcc1Chloride channel CLIC-like 1BC00324716413913.08
Protein complex
    Mrpl17Mitochondrial ribosomal protein L17BB343967112,98313.66
    Sfrs8Splicing factor, arginine/serine-rich 8BE6888161323967.53
    Clptm1Cleft lip and palate associated transmembrane protein 1NM_01964913738214.8
Metabolism
    Tssk1Testis-specific serine kinase 1NM_0094351196610.94
    Ndufb2NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2NM_0266121924,34310.32
    SpoplSpeckle-type POZ protein-likeBM11670343611,4194.71
    Mat2aMethionine adenosyltransferase II, alphaBB488978152199542.71
Unknown
    TollipToll interacting proteinBB4003041013767.10
    Zmynd19Zinc finger, MYND domain containing 19NM_02602121720203.22
    ZNF706Zinc finger protein 706AA16574918473855.33
    Clec14aC-type lectin domain family 14, member aNM_0258099813013.73
    DexiDexamethasone-induced transcriptNM_021428657409.9
    Rg9mtd2RNA (guanine-9-) methyltransferase domain containing 2BG0635573044647.22
    Rutbc2RUN and TBC1 domain containing 2AK0107561150378.84
    4833422M21RIKRIKEN cDNA 4833422M21 geneAK0147523610174.82
    4930455J16RIkRIKEN cDNA 4930455J16 geneAK0154704354556.99
    A630057N01RIKRIKEN cDNA A630057N01 geneBB22439788163392.85
    AFTPHAftiphilinBG0716811213236.78
    ANKRD13CAnkyrin repeat domain 13CAV1047074317605.36
    AU021889Expressed sequence AU021889BG068079518468.53
    C2ORF77Chromosome 2 open reading frame 77BE2824242116,8789.65
    D14Abb1eDNA segment, chromosome 14, Abbott 1 expressedBM2099085815374.73
    COMMD8COMM domain containing 8AV365904268716,1022.58
    DLX1ASDistal-less homeobox 1, antisenseAI32535016817553.38
    FAM19A1Family with sequence similarity 19, member A1AW1215498475806.50
    Thrap6Thyroid hormone receptor associated protein 6NM_02721231218182.54
    MSL1Male-specific lethal 1 homologAW495537811,95010.54
    MTG1Mitochondrial GTPase 1 homolog (S. cerevisiae)BC0273062343867.58
    Nalp9bNACHT, LRR and PYD containing protein 9bBG068754611477.58
    Surf6Surfeit gene 6NM_00929830319642.70
    TMEM203Transmembrane protein 203BC0226061048378.92
    TSPYL3TSPY-like 3 (pseudogene)BB30853238429082.92
    Btbd4BTB (POZ) domain containing 4AK0167009112203.74
    Tssc1Tumor suppressing subtransferable candidate 1BB08263416520323.62
    Pax6os1Pax6 opposite strand transcript 1BB255007510087.66
    Ttc21bTetratricopeptide repeat domain 21BAW55440135012,1195.11