Identified genes required for DNA damage–induced neural cell death
Category and gene symbol | Full gene name | GenBank accession no. | Control | MNNG | Log2 ratio |
---|---|---|---|---|---|
Cell death | |||||
Dedd | Death effector domain-containing | AK006814 | 937 | 9842 | 3.39 |
Eif2ak2 | Eukaryotic translation initiation factor 2 alpha kinase 2 | BE911144 | 3 | 7879 | 11.35 |
Fasl | Fas ligand (TNF superfamily, member 6) | NM_010177 | 304 | 3395 | 3.48 |
Trim39 | Tripartite motif-containing 39 | NM_024468 | 480 | 4511 | 3.23 |
CCR3 | Chemokine (C-C motif) receptor 3 | NM_009914 | 770 | 4474 | 2.54 |
NME1 | Non-metastatic cells 1, protein (NM23A) expressed in | AV156640 | 94 | 1710 | 4.19 |
GAS6 | Growth arrest-specific 6 | NM_019521 | 4 | 7793 | 10.93 |
VAMP3 | Vesicle-associated membrane protein 3 | BE994144 | 578 | 7037 | 3.61 |
NCOA1 | Nuclear receptor coactivator 1 | BE996469 | 1242 | 9787 | 2.98 |
IFI202B | Interferon activated gene 202B | AV229143 | 343 | 12,047 | 5.13 |
STAT3 | Signal transducer and activator of transcription 3 | AK004083 | 907 | 5156 | 2.51 |
ABCE1 | ATP-binding cassette, sub-family E, member 1 | BG063303 | 344 | 2480 | 2.85 |
CAPN2 | Calpain 2, (m/II) large subunit | NM_009794 | 1625 | 13,981 | 3.10 |
Map3k12 | Mitogen activated protein kinase kinase kinase 12 | BB370469 | 1 | 1069 | 9.92 |
Signal transduction | |||||
Sgsm1 | Small G protein signaling modulator 1 | AK010756 | 11 | 5037 | 8.84 |
Grm7 | Glutamate receptor, metabotropic 7 | BB539404 | 21 | 4723 | 7.81 |
V1ra5 | Vomeronasal 1 receptor, A5 | NM_053220 | 225 | 3542 | 3.98 |
Tbc1d8b | TBC1 domain family, member 8B | AK014817 | 1841 | 11,784 | 2.68 |
Fgf23 | Fibroblast growth factor 23 | AF263536 | 1344 | 14,077 | 3.39 |
Regulation of transcription | |||||
Pcgf6 | Polycomb group ring finger 6 | BC016195 | 100 | 1650 | 4.04 |
Bnc1 | Basonuclin 1 | U88064 | 200 | 2708 | 3.76 |
Zbtb46 | Zinc finger and BTB domain containing 46 | AK016700 | 91 | 1220 | 3.74 |
Med30 | Mediator complex subunit 30 | NM_027212 | 312 | 1818 | 2.54 |
E2f5 | E2F transcription factor 5 | BC003220 | 243 | 2547 | 3.39 |
Myt1 | Myelin transcription factor 1 | NM_008665 | 661 | 6287 | 3.25 |
1300003B13Rik | RIKEN cDNA 1300003B13 gene | AK004870 | 161 | 1427 | 3.15 |
Snap91 | Synaptosomal-associated protein 91 | BG068132 | 1 | 2092 | 11.3 |
Ccnl1 | Cyclin L1 | BB543556 | 1 | 2347 | 11.2 |
Protein kinase activity | |||||
Stk25 | Serine/threonine kinase 25 (yeast; Stk25) | BG068951 | 1 | 1499 | 10.55 |
Gucy2e | Guanylate cyclase 2e | NM_008192 | 1211 | 11,563 | 3.26 |
Tcp10c | T-complex protein-10 complete | AV257292 | 784 | 4904 | 2.65 |
Stk22a | Serine/threonine kinase 22A | NM_009435 | 1 | 1966 | 10.94 |
Oxidoreductase activity | |||||
Mosc2 | MOCO sulfurase C-terminal domain containing 2 | NM_133684 | 11 | 5283 | 8.91 |
Cyp2c65 | Cytochrome P450, family 2, subfamily c, polypeptide 65 | AK008688 | 283 | 4801 | 4.08 |
Hydrolase activity | |||||
Fbp2 | Fructose bisphosphatase 2 | NM_007994 | 3 | 5351 | 10.80 |
Pgam5 | Phosphoglycerate mutase family member 5 | BC021317 | 4 | 1533 | 8.58 |
Orc4l | Origin recognition complex, subunit 4-like | BB620704 | 27 | 1877 | 6.12 |
Mtm1 | X-linked myotubular myopathy gene 1 | NM_019926 | 1395 | 13,912 | 3.32 |
Ubiquitin-protein ligase activity | |||||
March1 | Membrane-associated ring finger (C3HC4) 1 | AK013582 | 1 | 4915 | 12.26 |
Transporter | |||||
Ubl7 | Ubiquitin-like 7 (bone marrow stromal cell-derived) | BC016456 | 11 | 1513 | 7.1 |
Sec15l1 | SEC15-like 1 (S. cerevisiae) | BC026859 | 471 | 2855 | 2.6 |
Clic5 | Chloride intracellular channel 5 | BB028501 | 25 | 1805 | 6.17 |
Slc8a1 | Solute carrier family 8, member 1 | BM123508 | 548 | 6850 | 3.64 |
Clcc1 | Chloride channel CLIC-like 1 | BC003247 | 164 | 1391 | 3.08 |
Protein complex | |||||
Mrpl17 | Mitochondrial ribosomal protein L17 | BB343967 | 1 | 12,983 | 13.66 |
Sfrs8 | Splicing factor, arginine/serine-rich 8 | BE688816 | 13 | 2396 | 7.53 |
Clptm1 | Cleft lip and palate associated transmembrane protein 1 | NM_019649 | 137 | 3821 | 4.8 |
Metabolism | |||||
Tssk1 | Testis-specific serine kinase 1 | NM_009435 | 1 | 1966 | 10.94 |
Ndufb2 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 | NM_026612 | 19 | 24,343 | 10.32 |
Spopl | Speckle-type POZ protein-like | BM116703 | 436 | 11,419 | 4.71 |
Mat2a | Methionine adenosyltransferase II, alpha | BB488978 | 1521 | 9954 | 2.71 |
Unknown | |||||
Tollip | Toll interacting protein | BB400304 | 10 | 1376 | 7.10 |
Zmynd19 | Zinc finger, MYND domain containing 19 | NM_026021 | 217 | 2020 | 3.22 |
ZNF706 | Zinc finger protein 706 | AA165749 | 184 | 7385 | 5.33 |
Clec14a | C-type lectin domain family 14, member a | NM_025809 | 98 | 1301 | 3.73 |
Dexi | Dexamethasone-induced transcript | NM_021428 | 6 | 5740 | 9.9 |
Rg9mtd2 | RNA (guanine-9-) methyltransferase domain containing 2 | BG063557 | 30 | 4464 | 7.22 |
Rutbc2 | RUN and TBC1 domain containing 2 | AK010756 | 11 | 5037 | 8.84 |
4833422M21RIK | RIKEN cDNA 4833422M21 gene | AK014752 | 36 | 1017 | 4.82 |
4930455J16RIk | RIKEN cDNA 4930455J16 gene | AK015470 | 43 | 5455 | 6.99 |
A630057N01RIK | RIKEN cDNA A630057N01 gene | BB224397 | 881 | 6339 | 2.85 |
AFTPH | Aftiphilin | BG071681 | 12 | 1323 | 6.78 |
ANKRD13C | Ankyrin repeat domain 13C | AV104707 | 43 | 1760 | 5.36 |
AU021889 | Expressed sequence AU021889 | BG068079 | 5 | 1846 | 8.53 |
C2ORF77 | Chromosome 2 open reading frame 77 | BE282424 | 21 | 16,878 | 9.65 |
D14Abb1e | DNA segment, chromosome 14, Abbott 1 expressed | BM209908 | 58 | 1537 | 4.73 |
COMMD8 | COMM domain containing 8 | AV365904 | 2687 | 16,102 | 2.58 |
DLX1AS | Distal-less homeobox 1, antisense | AI325350 | 168 | 1755 | 3.38 |
FAM19A1 | Family with sequence similarity 19, member A1 | AW121549 | 84 | 7580 | 6.50 |
Thrap6 | Thyroid hormone receptor associated protein 6 | NM_027212 | 312 | 1818 | 2.54 |
MSL1 | Male-specific lethal 1 homolog | AW495537 | 8 | 11,950 | 10.54 |
MTG1 | Mitochondrial GTPase 1 homolog (S. cerevisiae) | BC027306 | 23 | 4386 | 7.58 |
Nalp9b | NACHT, LRR and PYD containing protein 9b | BG068754 | 6 | 1147 | 7.58 |
Surf6 | Surfeit gene 6 | NM_009298 | 303 | 1964 | 2.70 |
TMEM203 | Transmembrane protein 203 | BC022606 | 10 | 4837 | 8.92 |
TSPYL3 | TSPY-like 3 (pseudogene) | BB308532 | 384 | 2908 | 2.92 |
Btbd4 | BTB (POZ) domain containing 4 | AK016700 | 91 | 1220 | 3.74 |
Tssc1 | Tumor suppressing subtransferable candidate 1 | BB082634 | 165 | 2032 | 3.62 |
Pax6os1 | Pax6 opposite strand transcript 1 | BB255007 | 5 | 1008 | 7.66 |
Ttc21b | Tetratricopeptide repeat domain 21B | AW554401 | 350 | 12,119 | 5.11 |