Table 2.

Peak-aligned pairwise comparisons (collapsed drug groups)

p-values (t test)Core (control) vs. Shell (control)Core (control) vs. both cocainesShell (control) vs. both cocaines
Peak [DA], µm0. 10.20.40.80.10.20.40.80.10.20.40.8
Peak0.870.230.970.320.11<0.0001*0.280.260.860.240.490.13
Frequency0.007*0.002*0.540.910.001*0.120.180.340.660.100.130.53
AUC0.020.030.001*0.008*0.980.720.200.070.050.040.070.33
Rise velocity<0.0001*<0.0001*<0.0001*0.004*<0.0001*<0.0001*<0.0001*<0.0001*0.070.080.820.17
Latency peak<0.0001*<0.0001*<0.0001*<0.0001*0.0004*<0.0001*<0.0001*<0.0001*0.670.700.370.96
Vmax<0.0001*<0.0001*<0.0001*0.01<0.0001*<0.0001*<0.0001*0.0008*0.050.200.480.35
FWHH<0.0001*<0.0001*<0.0001*<0.0001*0.0004*<0.0001*<0.0001*<0.0001*0.320.470.120.64
Slope (T20–T80)<0.0001*<0.0001*0.520.800.160.001*0.100.190.003*0.080.270.01
Baseline return0.0002*0.002*0.600.630.160.300.490.870.007*0.050.990.70
T20 latency<0.0001*<0.0001*<0.0001*<0.0001*0.0002*<0.0001*<0.0001*<0.0001*0.620.500.070.71
T80 latency<0.0001*0.0006*0.020.850.0008*0.0001*0.007*0.001*0.060.250.270.16
  • Significance (p-value) of pairwise t tests at each peak bin (low [<0.1 μm DA], medium-low [0.1–0.2 μm DA], medium-high [0.2–0.4 μm DA], and high [0.4–0.8 μm DA]) between core control and shell control (left; repeated from Table 1), core control and average of both cocaine groups (core and shell; middle), and shell control average of both cocaine groups (core and shell; right). Bold italics: *p < 0.01 (significant after Bonferroni correction); italics only: p < 0.05 (not significant after Bonferroni correction).