Table 2:

Estradiol alters hypothalamic gene expression in female mice fed a HFD

Gene of InterestVeh-HFDE2-HFD
Bcl-210.56 (±0.74)8.74 (±0.89)
BDNF1.23 (±0.13)0.77 (±0.24)
Caspase39.93 (±3.54)16.15 (±4.37)
CNTF1.80 (±0.54)1.04 (±0.44)
Fgf101.13 (±0.43)0.22 (±0.17)*
IκB kinase β3.16 (±1.23)3.45 (±1.23)

  • Estradiol decreased the relative expression of Fgf10 in the hypothalamus of female mice fed a HFD.

  • ↵* p = 0.027gg E2 vs Veh.