Summary of the starting and final conductance ranges found using the semi-automated strategy for S.1, S.2, and SD
| Distribution label | GNa,t (S/cm2) | GNa,p (S/cm2) | GKa (S/cm2) | GKdrf (S/cm2) | GKdrs (S/cm2) |
|---|---|---|---|---|---|
| S.1 start | 0.08, 0.12, 0.16, 0.20 | 0.0002, 0.0003, 0.0004 | 0.05, 0.10, 0.15 | 0.04, 0.08, 0.12 | 0.04, 0.08, 0.12 |
| S.1 final | 0.16, 0.18, 0.20, 0.22 | 0.0001, 0.0002, 0.0003 | 0.05, 0.10, 0.15 | 0.03, 0.07, 0.11 | 0.03, 0.06, 0.09 |
| S.2 start | 0.2, 0.225, 0.25 | 0.0001, 0.00015, 0.0002 | 0.15, 0.20, 0.25 | 0.8, 0.9, 1.0(faster) | 0 |
| S.2 final | 0.2, 0.225, 0.25 | 0.00005, 0.00010, 0.00015 | 0.15, 0.20, 0.25 | 0.95, 1.0, 1.05(faster) | 0 |
| SD start | 0.04, 0.05, 0.06 | 0.0002, 0.0004, 0.0006 | 0.06, 0.08, 0.1 | 0.05, 0.10, 0.15(faster) | 0 |
| SD final | 0.04, 0.05, 0.06 | 0.0002, 0.0004, 0.0004 | 0.06, 0.08, 0.1 | 0.1, 0.13, 0.16(faster) | 0 |
| SDprox.1 start | 0.05, 0.075, 0.1(50, 70, 90 μm) | 0.00005, 0.00010, 0.00015 | 0.03, 0.05, 0.07(50, 70, 90 μm) | 0.2, 0.3, 0.4(faster)(50, 70, 90 μm) | 0 |
| SDprox.1 final | 0.07, 0.0725, 0.075(50, 70, 90 μm) | 0.00005, 0.000075, 0.0001 | 0.03, 0.05, 0.07(50, 70, 90 μm) | 0.25, 0.275, 0.3(faster)(50, 70, 90 μm) | 0 |
| SDprox.2 start | 0.055, 0.1025, 0.15(50, 70, 90 μm) | 0.00005, 0.00010, 0.00015 | 0.03, 0.05, 0.07 | 0.2, 0.3, 0.4(faster)(50, 70, 90 μm) | 0 |
| SDprox.2 final | 0.055, 0.060, 0.065(50, 70, 90 μm) | 0.00005, 0.00010, 0.00015 | 0.03, 0.05, 0.07 | 0.27, 0.295, 0.32(faster)(50, 70, 90 μm) | 0 |
Note that for the SDprox.1 and SDprox.2 distributions, we also investigated channels that were uniform in soma and dendrites up until 50, 70, and 90 μm from the soma. The choice of the number of conductance values to use was determined by balancing parameter space resolution against computational speed.