Table 3.

Proteins coimmunopurified with β2*-nAChRs from postmortem human temporal cortex with abundances that correlate significantly with the abundance of the β2 nAChR subunit

AccessionDescriptionCorrelation (r)p Valuen
ACHB2_HUMANNeuronal acetylcholine receptor subunit β21018
ACHA4_HUMANNeuronal acetylcholine receptor subunit α40.972<0.000918
AT1B1_HUMANSodium/potassium-transporting ATPase subunit β10.889<0.000918
AT1A3_HUMANSodium/potassium-transporting ATPase subunit α30.888<0.000918
SNP25_HUMANSynaptosomal-associated protein 250.88<0.000918
STX1B_HUMANSyntaxin-1B0.874<0.000918
AT1A1_HUMANSodium/potassium-transporting ATPase subunit α10.871<0.000918
ANK2_HUMANAnkyrin-20.856<0.000918
STX1A_HUMANSyntaxin-1A0.844<0.000918
GPM6A_HUMANNeuronal membrane glycoprotein M6-a0.823<0.000918
AT2B2_HUMANPlasma membrane calcium-transporting ATPase 20.781<0.000918
GNAO_HUMANGuanine nucleotide-binding protein G(o) subunit α0.781<0.000918
VPP1_HUMANV-type proton ATPase 116 kDa subunit a isoform 10.777<0.000918
MYPR_HUMANMyelin proteolipid protein0.762<0.000918
GBB1_HUMANGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit β10.7020.00118
EAA2_HUMANExcitatory amino acid transporter 20.7010.00118
VA0D1_HUMANV-type proton ATPase subunit d 10.6440.00418
MYH9_HUMANMyosin-90.6310.00518
AT1A2_HUMANSodium/potassium-transporting ATPase subunit α20.6090.00718
TBB5_HUMANTubulin β chain0.5760.01218
TBA1A_HUMANTubulin α1A chain0.560.01618
1433Z_HUMAN14-3-3 protein zeta/delta0.5480.01918
STXB1_HUMANSyntaxin-binding protein 10.5260.02518
SYT1_HUMANSynaptotagmin-10.5230.02618
CLH1_HUMANClathrin heavy chain 10.5150.04118
TBA4A_HUMANTubulin α4A chain0.5140.02918
S10A7_HUMANProtein S100-A70.5110.0318
TBA1B_HUMANTubulin α1B chain0.5060.03218
RO52_HUMANE3 ubiquitin-protein ligase TRIM210.4920.03818
ODO2_HUMANDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex0.4830.04218
TBB4A_HUMANTubulin β4A chain0.4760.04618
MYO5A_HUMANUnconventional myosin-Va0.4750.04618
TPM4_HUMANTropomyosin α4 chain0.4730.04718
  • High correlation indicates the identified protein is either specifically interacting with the receptor at the time of tissue lysis or is part of a complex that stays intact following extraction in Triton X-100. The cluster of proteins with correlation coefficients <0.7 is evidence of significant enrichment of presynaptic components critical for neurotransmitter release and neuronal excitability.