Tabulation of all proteins identified from mAb295-immunoisolated β2*-nAChRs from human temporal cortex, indicating which proteins have been identified in mouse cortex or whole mouse brain (Iso, isoform of protein identified; GN, gene name)
| Accession_HUMAN | Description | Mouse Ctx | Mouse Brain |
|---|---|---|---|
| 1433E | 14-3-3 protein ε GN = YWHAE | Iso | Iso |
| 1433G;1433F | 14-3-3 protein γ GN = YWHAG | Iso | Iso |
| 1433S | 14-3-3 protein σ GN = SFN | Iso | Iso |
| 1433Z | 14-3-3 protein ζ/δ GN = YWHAZ | Iso | Yes |
| ACHA4;ACHA2;ACHA6 | Neuronal acetylcholine receptor subunit α4 GN = CHRNA4 | Yes | Yes |
| ACHB2 | Neuronal acetylcholine receptor subunit β2 GN = CHRNB2 | Yes | Yes |
| ACTB;ACTBM;POTEE | Actin, cytoplasmic 1 GN = ACTB | Yes | Iso |
| ACTC;ACTA | Actin, α cardiac muscle 1 GN = ACTC1 | Iso | Yes |
| ACTN1;ACTN3 | α-Actinin-1 GN = ACTN1 | No | Yes |
| ACTN2 | α-Actinin-2 GN = ACTN2 | No | Yes |
| ACTN4 | α-Actinin-4 GN = ACTN4 | No | Iso |
| ADDA | α-Adducin GN = ADD1 | No | No |
| ADT1;ADT2;ADT4 | ADP/ATP translocase 1 GN = SLC25A4 | Yes | Yes |
| ALBU | Serum albumin GN = ALB | No | No |
| ANK2 | Ankyrin-2 GN = ANK2 | No | Yes |
| AP1B1 | AP-1 complex subunit β1 GN = AP1B1 | No | No |
| ARP2 | Actin-related protein 2 GN = ACTR2 | No | Iso |
| ARP3 | Actin-related protein 3 GN = ACTR3 | No | Yes |
| ARPC3 | Actin-related protein 2/3 complex subunit 3 GN = ARPC3 | No | Iso |
| ARPC4 | Actin-related protein 2/3 complex subunit 4 GN = ARPC4 | No | Iso |
| AT1A1;AT12A | Sodium/potassium-transporting ATPase subunit α1 GN = ATP1A1 | Iso | Iso |
| AT1A2 | Sodium/potassium-transporting ATPase subunit α2 GN = ATP1A2 | Iso | Yes |
| AT1A3;AT1A4;ATP4A | Sodium/potassium-transporting ATPase subunit α3 GN = ATP1A3 | Yes | Yes |
| AT1B1 | Sodium/potassium-transporting ATPase subunit β1 GN = ATP1B1 | Yes | Yes |
| AT2B2;AT2B1 | Plasma membrane calcium-transporting ATPase 2 GN = ATP2B2 | No | No |
| ATPA | ATP synthase subunit α, mito GN = ATP5A1 | Yes | Yes |
| ATPB | ATP synthase subunit β, mito GN = ATP5B | Yes | Yes |
| BASP1 | Brain acid-soluble protein 1 GN = BASP1 | No | No |
| CALM | Calmodulin GN = CALM1 | Yes | Yes |
| CANB1 | Calcineurin subunit B type 1 GN = PPP3R1 | No | No |
| CLH1 | Clathrin heavy chain 1 GN = CLTC SV = 5 | Yes | No |
| CNTN1 | Contactin-1 GN = CNTN1 | No | Yes |
| COX2 | Cytochrome c oxidase subunit 2 GN = MT-CO2 | No | Yes |
| COX41 | Cytochrome c oxidase subunit 4 isoform 1, mito GN = COX4I1 | No | Yes |
| COX6C | Cytochrome c oxidase subunit 6C GN = COX6C | No | Yes |
| CX6B1 | Cytochrome c oxidase subunit 6B1 GN = COX6B1 | No | Yes |
| CX7A2 | Cytochrome c oxidase subunit 7A2, mito GN = COX7A2 | No | Yes |
| DREB | Drebrin GN = DBN1 | No | Yes |
| DYN1 | Dynamin-1 GN = DNM1 | No | No |
| E41L3 | Band 4.1-like protein 3 GN = EPB41L3 | No | No |
| EAA1 | Excitatory amino acid transporter 1 GN = SLC1A3 | Iso | Iso |
| EAA2 | Excitatory amino acid transporter 2 GN = SLC1A2 | Yes | Yes |
| EF1A1;EF1A2 | Elongation factor 1-α1 GN = EEF1A1 | No | No |
| FCGBP | IgGFc-binding protein GN = FCGBP | No | No |
| FRIH | Ferritin heavy chain GN = FTH1 | No | No |
| FRIL | Ferritin light chain GN = FTL | No | No |
| G3P | Glyceraldehyde-3-phosphate dehydrogenase GN = GAPDH | Yes | Yes |
| GBB1;GBB2;GBB3;GBB4 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit β1 GN = GNB1 | Yes | Yes |
| GELS | Gelsolin GN = GSN | No | Yes |
| GFAP | Glial fibrillary acidic protein GN = GFAP | Yes | Yes |
| GNAO;GNA12 | Guanine nucleotide-binding protein G(o) subunit α GN = GNAO1 | Yes | Yes |
| GPM6A | Neuronal membrane glycoprotein M6-a GN = GPM6A | No | No |
| H13 | Histone H1.3 GN = HIST1H1D | No | Iso |
| H2A1B | Histone H2A type 1-B/E GN = HIST1H2AB | No | Yes |
| H2B1M;H2B1A | Histone H2B type 1-M GN = HIST1H2BM | No | Yes |
| H4 | Histone H4 GN = HIST1H4A | No | Yes |
| HBA | Hemoglobin subunit α GN = HBA1 | No | Iso |
| HBB;HBD | Hemoglobin subunit β GN = HBB | No | Yes |
| HORN | Hornerin GN = HRNR | No | No |
| HS12A | Heat shock 70 kDa protein 12A GN = HSPA12A | No | Iso |
| HS71L | Heat shock 70 kDa protein 1-like GN = HSPA1L | No | Iso |
| HSPB1 | Heat shock protein β1 GN = HSPB1 | No | Iso |
| IGHG4;IGHG2 | Ig γ-4 chain C region GN = IGHG4 | No | Iso |
| IGHM | Ig μ chain C region GN = IGHM | No | Yes |
| IGKC | Ig κ chain C region GN = IGKC | No | Iso |
| KCC2A;KCC2D | Calcium/calmodulin-dependent protein kinase type II subunit α GN = CAMK2A | Yes | Yes |
| KCC2B;KCC2G | Calcium/calmodulin-dependent protein kinase type II subunit β GN = CAMKIIB | Yes | Yes |
| MBP | Myelin basic protein GN = MBP | Yes | Yes |
| ML12A;MYL9 | Myosin regulatory light chain 12A GN = MYL12A | No | Iso |
| MOG | Myelin-oligodendrocyte glycoprotein GN = MOG | No | No |
| MPCP | Phosphate carrier protein, mito GN = SLC25A3 | Yes | Yes |
| MYH10 | Myosin-10 GN = MYH10 | Yes | Yes |
| MYH9;MYH11;MYH14 | Myosin-9 GN = MYH9 | Iso | Yes |
| MYL6;MYL6B | Myosin light polypeptide 6 GN = MYL6 | Yes | Yes |
| MYO5A;MYO5B | Unconventional myosin-Va GN = MYO5A | No | Yes |
| MYPR | Myelin proteolipid protein GN = PLP1 | No | Yes |
| NDUA4 | Cytochrome c oxidase subunit NDUFA4 GN = NDUFA4 | Yes | Iso |
| NDUS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mito GN = NDUFS3 | Yes | Yes |
| NDUV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mito GN = NDUFV2 | Yes | Yes |
| NFL | Neurofilament light polypeptide GN = NEFL | Yes | Yes |
| NFM | Neurofilament medium polypeptide GN = NEFM | Yes | Yes |
| NSF | Vesicle-fusing ATPase GN = NSF | No | Yes |
| ODB2 | Lipoamide acyltransferase of branched-chain α-keto acid dehydrogenase mito GN = DBT | No | Yes |
| ODO2 | Dihydrolipoyllysine-residue succinyltransferase 2-oxoglutarate dehydrogenase mito GN = DLST | Yes | Yes |
| QCR2 | Cytochrome b-c1 complex subunit 2, mito GN = UQCRC2 | No | Yes |
| RAB1A | Ras-related protein Rab-1A GN = RAB1A | Iso | Yes |
| RL40 | Ubiquitin-60S ribosomal protein L40 GN = UBA52 | No | No |
| RO52 | E3 ubiquitin-protein ligase TRIM21 GN = TRIM21 | No | No |
| S10A7;S1A7A | Protein S100-A7 GN = S100A7 | No | No |
| S10A8 | Protein S100-A8 GN = S100A8 | No | No |
| S10A9 | Protein S100-A9 GN = S100A9 | No | No |
| SIR2 | NAD-dependent protein deacetylase sirtuin-2 GN = SIRT2 | No | No |
| SNP25 | Synaptosomal-associated protein 25 GN = SNAP25 | Yes | Yes |
| SPTB2;SPTB1 | Spectrin β chain, nonerythrocytic 1 GN = SPTBN1 | Yes | Yes |
| SPTN1 | Spectrin α chain, nonerythrocytic 1 GN = SPTAN1 | Yes | Yes |
| SPTN2 | Spectrin β chain, nonerythrocytic 2 GN = SPTBN2 | Iso | Iso |
| SSBP | Single-stranded DNA-binding protein, mito GN = SSBP1 | No | No |
| STX1A | Syntaxin-1A GN = STX1A | Iso | Iso |
| STX1B;STX2 | Syntaxin-1B GN = STX1B | Yes | Yes |
| STXB1 | Syntaxin-binding protein 1 GN = STXBP1 | No | Yes |
| SV2A | Synaptic vesicle glycoprotein 2A GN = SV2A | No | No |
| SYT1 | Synaptotagmin-1 GN = SYT1 | Yes | Yes |
| TBA1A,C;TBA3C,E;TBA8 | Tubulin α1A chain GN = TUBA1A | Iso | Yes |
| TBA1B | Tubulin α1B chain GN = TUBA1B | Iso | Iso |
| TBA4A;TBA4B;TBAL3 | Tubulin α4A chain GN = TUBA4A | Yes | Yes |
| TBB2A;TBB1;TBB2B | Tubulin β2A chain GN = TUBB2A | Yes | Yes |
| TBB3 | Tubulin β3 chain GN = TUBB3 | Yes | Yes |
| TBB4A;TBB6,8;TBB8L | Tubulin β4A chain GN = TUBB4A | Yes | Yes |
| TBB4B | Tubulin β4B chain GN = TUBB4B | Yes | Yes |
| TBB5 | Tubulin β chain GN = TUBB | Yes | Yes |
| THY1 | Thy-1 membrane glycoprotein GN = THY1 | Yes | No |
| TMOD2 | Tropomodulin-2 GN = TMOD2 | No | Yes |
| TPM4;TPM1 | Tropomyosin α4 chain GN = TPM4 | Iso | No |
| VA0D1;VA0D2 | V-type proton ATPase subunit d 1 GN = ATP6V0D1 | Yes | Iso |
| VAMP3 | Vesicle-associated membrane protein 3 GN = VAMP3 | No | Iso |
| VATA | V-type proton ATPase catalytic subunit A GN = ATP6V1A | Yes | Yes |
| VISL1 | Visinin-like protein 1 GN = VSNL1 | No | No |
| VPP1 | V-type proton ATPase 116 kDa subunit a isoform 1 GN = ATP6V0A1 PE = 2 | Yes | Iso |