Table 2:

Multivariate models predicting percentage change in hippocampal complex thickness

	Predictors	Coefficients				R²
		β	SE	t value	p value

Model 1: unweighted risk score	Constant	17.153	5.994	2.862	0.007**
	Age	−0.102	0.079	1.291	0.204
	Sex	−2.730	1.409	−1.938	0.060
	Years between visits	−2.863	0.893	−3.207	0.003**
	Unweighted risk score	−1.322	0.583	−2.270	0.028*
					<0.001	0.364
Model 2: weighted risk score	Constant	17.032	6.144	2.772	0.008**
	Age	−0.144	0.079	−1.826	0.075
	Sex	−3.735	1.337	−2.793	0.008**
	Years between visits	−2.901	0.915	−3.172	0.003**
	Weighted risk score	−3.101	1.763	−1.758	0.086
					0.002	0.333
Model 3: APOE	Constant	17.227	6.255	2.754	0.009**
	Age	−0.150	0.080	−1.872	0.068
	Sex	−4.080	1.349	−3.024	0.004**
	Years between visits	−2.981	0.932	−3.199	0.003**
	APOE	−1.249	0.869	−1.437	0.158
					0.003	0.317
Model 4: family history	Constant	15.945	6.310	2.527	0.016*
	Age	−0.146	0.082	−1.782	0.082
	Sex	−3.702	1.435	−2.579	0.014*
	Years between visits	−2.699	0.960	−2.810	0.008**
	FH	−0.895	1.404	−0.637	0.528
					0.007	0.289

**p<0.01
*p<0.05