Group 1 | Group 2 | Group 3 | ||||
---|---|---|---|---|---|---|
Saline | METH | Saline | METH | Saline | METH | |
AP peak (mV)* | −0.97 ± 1.70 | −0.72 ± 4.28 | 34.59 ± 2.26 | 40.95 ± 1.70 | 45.27 ± 1.72 | 46.18 ± 2.50 |
AP amplitude (mV)* | 29.38 ± 3.10 | 30.25 ± 5.99 | 80.57 ± 3.86 | 85.83 ± 2.81 | 95.24 ± 1.47 | 94.43 ± 2.94 |
AP area (mV · ms) | 78.71 ± 3.63 | 75.44 ± 6.68 | 91.27 ± 5.42 | 84.50 ± 7.36 | 92.91 ± 2.97 | 85.47 ± 3.84 |
Half-width (ms)* | 3.38 ± 0.45 | 3.35 ± 0.69 | 0.98 ± 0.10 | 0.79 ± 0.06 | 0.85 ± 0.04 | 0.79 ± 0.05 |
Cm (pF)* | 21.66 ± 0.77 | 19.96 ± 1.18 | 40.02 ± 3.21 | 42.39 ± 7.32 | 56.00 ± 3.13 | 49.96 ± 3.22 |
Rin (GΩ)* | 2.32 ± 0.16 | 2.35 ± 0.18 | 0.68 ± 0.11 | 0.92 ± 0.15 | 0.38 ± 0.03 | 0.36 ± 0.03 |
RMP (mV)* | −38.00 ± 1.76 | −36.25 ± 4.09 | −62.01 ± 3.39 | −58.79 ± 2.87 | −68.17 ± 1.20 | −69.21 ± 1.53 |
Values are given as the mean ± SEM. METH induced no effect in all parameters analyzed. Cm, membrane capacitance; Rin, input resistance; RMP, resting membrane potential.
*Significantly different, using Kruskal–Wallis test followed by Dunn’s post hoc test or Bonferroni’s post hoc test. Asterisks correspond to statistical significance (p < 0.05) between group 1 and group 2 GFP+ DGCs, and between group 2 and group 3 GFP+ DGCs in saline conditions.