Table 1.

Biomechanical and biophysical parameters for the simulation runs

	Parameter	Symbol	Unit	Value	Source
Biomechanical Parameters
1	Thickness of the leaflet		nm	2	Plaksin et al., 2014
2	Initial gap between the two leaflets (uncharged)			1.4
3	Initial gap between the two leaflets (when charged)			1.26 (RS)	Calculated from equilibrium state using Plaksin et al., 2014, their Eq. 2
4				1.26 (FS)
5				1.3 (LTS)
6				1.28 (TC)
7				1.21 (RE)
8	Attraction/repulsion pressure coefficient		Pa	10⁵	Plaksin et al., 2014
9	Exponent in the repulsion term	x	—	5
10	Exponent in the attraction term	_y	—	3.3
11	Dynamic viscosity of the leaflets		Pa·s	0.035
12	Dynamic viscosity of the surrounding medium			0.7·10⁻³
13	Diffusion coefficient of air in the surrounding medium		m²·s⁻¹	3·10⁻⁹
14	Density of the surrounding medium		kg·m⁻³	1028
15	Speed of sound in the surrounding medium		m·s⁻¹	1515
16	Initial air molar concentration in the surrounding medium (O₂+N₂)		mol·m⁻³	0.62
17	Henry’s constant for dissolved air in the surrounding medium		Pa·m³·mol⁻¹	1.63·10⁵
18	Static pressure in the surrounding medium		Pa	10⁵
19	Radius of the leaflets' boundary	a	nm	32
20	Width of the boundary layer between the surrounding medium and the leaflets		nm	0.5
21	Areal modulus of the bilayer membrane		N·m⁻¹	0.24
22	Relative permittivity of the intramembrane cavity		—	1
23	Membrane baseline capacitance per unit area		µF·cm⁻²	1
24	Surrounding medium temperature	Tem	K	309.15	Pospischil et al., 2008; Destexhe et al., 1998a
Biophysical parameters
25	Maximal conductance of Na⁺ channels		mS·cm⁻²	56 (RS)	Pospischil et al., 2008
				50 (RS; Fig. 7)
26				58 (FS)
				50 (FS; Fig. 7)
27				50 (LTS)
28				90 (TC)	Destexhe et al., 1998a
29				200 (RE)
30	Maximal conductance of delayed-rectiﬁer K⁺ channels			6 (RS)	Pospischil et al., 2008
				5 (RS; Fig. 7)
31				3.9 (FS)
				10 (FS; Fig. 7)
32				4 (LTS)
				5 (LTS; Fig. 7)
33				10 (TC)	Destexhe et al., 1998a
34				20 (RE)
35	Maximal conductance of slow non-inactivating K⁺ channels			0.075 (RS)	Pospischil et al., 2008
				0.07 (RS; Fig. 7)
36				0.0787 (FS)
				0 (FS; Fig. 7)
37				0.028 (LTS)
				0.03 (LTS; Fig. 7)
38	Maximal conductance of low-threshold Ca²⁺ channels			0.4 (LTS)
39				2 (TC)	Destexhe et al., 1998a
40	Maximal conductance of low- threshold Ca²⁺ channels			3 (RE)
41	Maximal conductance of leak potassium currents			0.0138 (TC)
42	Maximal conductance of hyperpolarization-activated mixed cationic current			0.0175 (TC)
43	Maximal conductance of non-voltage-dependent, nonspecific ions channels			0.0205 (RS)	Pospischil et al., 2008
				0.1 (RS; Fig. 7)
44				0.038 (FS)
				0.15 (FS; Fig. 7)
45				0.019 (LTS)
				0.01 (LTS; Fig. 7)
46				0.01 (TC)	Destexhe et al., 1998a
47				0.05 (RE)
48	Nernst potential of Na⁺		mV	50	Pospischil et al., 2008
49	Nernst potential of K⁺			−90
50	Nernst potential of Ca²⁺ (LTS neuron)			120
51	Reversal potential of a hyperpolarization-activated mixed cationic current			−40	Destexhe et al., 1996a
52	Nernst potential of non-voltage-dependent, nonspecific ion channels			−70.3 (RS)	Pospischil et al., 2008
				−70 (RS; Fig. 7)
53				−70.4 (FS)
				−70 (FS; Fig. 7)
54				−50 (LTS)
				−85 (LTS; Fig. 7)
55				−70 (TC)	Destexhe et al., 1998a
56				−90 (RE)
57	Spike threshold adjustment parameter			−56.2 (RS)	Pospischil et al., 2008
				−55 (RS; Fig. 7)
58				−57.9 (FS)
				−55 (FS; Fig. 7)
59				−50 (LTS)
				−55 (LTS; Fig. 7)
60				−52 (TC)	Destexhe et al., 1998b
61				−67 (RE)	Destexhe et al., 1996b
62	Decay time constant for adaptation at slow non-inactivating K⁺ channels		ms	608 (RS)	Pospischil et al., 2008
				1000 (RS; Fig. 7)
63				502 (FS)
				1000 (FS; Fig. 7)
64				4000 (LTS)
				1000 (LTS; Fig. 7)
65	The resting potential of the cell membrane		mV	−71.9 (RS)	Calculated from Pospischil et al., 2008
				−70.4 (RS; Fig. 7)
66				−71.4 (FS)
				−70 (FS; Fig. 7)
67				−54 (LTS)
				−84.6 (LTS – Fig. 7)
68				−63.4 (TC)	Calculated from Destexhe et al., 1998a
69				−89.5 (RE)
70	The effective depth beneath the membrane area for calcium concentration calculations (for TC and RE neurons)		nm	100	Destexhe et al., 1998a and Destexhe et al., 1996a
71	An extracellular Ca²⁺ concentration (for TC and RE neurons)		mm	2
72	Decay time constants of Ca²⁺ (for TC and RE neurons)		ms	5
73	current Ca²⁺ regulation factor		mm ⁻⁴· ms⁻¹	2.5·10⁷
74	current Ca²⁺ regulation factor		ms⁻¹	4·10⁻⁴
75	current Ca²⁺ regulation factor			0.1
76	current Ca²⁺ regulation factor			0.001
77	FS to RS neuron thalamic input current ratio	R_TH	—	1.4	Hayut et al., 2011
78	Thalamic DC current input to the RS neuron		nA	0.17	Based on Destexhe and Paré.,1999
79	AMPA synaptic currents reversal potential		mV	0	Destexhe et al., 1996a
80	GABA_A synaptic currents reversal potential			-85
81	Total maximal synaptic conductance used for RS to RS connection		μS	0.002	Calculated from Vierling-Claassen et al., 2010
82	Total maximal synaptic conductance used for RS to FS connection			0.04
83	Total maximal synaptic conductance used for RS to LTS connection			0.09
84	Total maximal synaptic conductance used for FS to RS connection			0.015
85	Total maximal synaptic conductance used for FS to FS connection			0.135
86	Total maximal synaptic conductance used for FS to LTS connection			0.86
87	Total maximal synaptic conductance used for LTS to RS connection			0.135
88	Total maximal synaptic conductance used for LTS to FS connection			0.02
89	AMPA rise time constant		ms	0.1	Vierling-Claassen et al., 2010
90	AMPA decay time constant			3
91	GABA_A rise time constant from FS neuron			0.5
92	GABA_A decay time constant from FS neuron			8
93	GABA_A rise time constant from LTS neuron			0.5
94	GABA_A decay time constant from LTS neuron			50
95	Short-term synaptic plasticity facilitation factor (from RS to LTS)	f	—	0.2
96	Short-term synaptic plasticity facilitation factor time constant (from RS to LTS)		ms	200
97	Short-term synaptic plasticity facilitation factor (from RS to FS)	f	—	0.5
98	Short-term synaptic plasticity facilitation factor time constant (from RS to FS)		ms	94
99	Short-term synaptic plasticity short-time depression factor (from RS to FS)		—	0.46
100	Short-term synaptic plasticity short-time depression factor time constant (from RS to FS)		ms	380
101	Short-term synaptic plasticity long-time depression factor (from RS to FS)		—	0.975
102	Short-term synaptic plasticity long-time depression factor time constant (from RS to FS)		ms	9200
103	Neuronal cell membrane area	A	μm²	11.88·10³ (RS)	Pospischil et al., 2008
104				10.17·10³ (FS)
105				25·10³ (LTS)
106				29·10³ (TC)	Destexhe et al., 1998a
107				14·10³ (RE)

The synaptic strengths were calculated from Vierling-Claassen et al. (2010), multiplying their individual synaptic strengths by the average number of converging connections from each type (Vierling-Claassen et al., 2010, their Table 3) and by the ratio of membrane areas between the NICE-neuron model and the respective model in their study. The latter normalization is consistent with an assumption that the total number of putative synapses on the dendrites and soma are proportional to a neuron's size (Gibbins et al., 1998).