Figure 2B, DA | assumed normal distribution | two-sample t test (equal variance) | (−7.812, 2.823) |

Figure 2B, DOPAC/DA | assumed normal distribution | two-sample t test (equal variance) | (−0.008933, 0.03776) |

Figure 2B, HVA/DA | assumed normal distribution | two-sample t test (equal variance) | (−0.01168, 0.05225 |

Figure 3B, left graph | assumed normal distribution | two-sample t test (equal variance) | (−0.3303, 0.1928) |

Figure 3B, right graph | assumed normal distribution | two-sample t test (equal variance) | (−0.3542, 0.1798) |

Figure 3C | assumed normal distribution | two-sample t test (equal variance) | (−0.1550, 0.1628) |

Figure 4B | no assumptions | two-sample Kolmogorov–Smirnov | no confidence intervals |

Figure 4C, not-induced | assumed symmetry around the median | Wilcoxon signed rank test | (1.4670, 6.3505) |

Figure 4C, TAM treated | assumed symmetry around the median | Wilcoxon signed rank test | (1.038, 3.582) |

Figure 4C, NR1^{D1CreERT2} | assumed symmetry around the median | Wilcoxon signed rank test | (0.384, 4.348) |

Figure 4D | no assumptions | two-sample Kolmogorov–Smirnov | no confidence intervals |

Figure 5A | assumed normal distribution | Two-sample *t* test (equal variance) | (17.924, 21.602) |

Figure 5B | assumed normal distribution | Two-sample *t* test (equal variance) | (47.978, 51.000) |

Figure 5C | assumed normal distribution | Two-sample *t* test (equal variance) | (−21.381, 44.754) |

Figure 6A, cocaine score comparison | assumed normal distribution | Welch *t* test | (29.66433, 401.93406) |

Figure 6B, morphine score comparison | assumed normal distribution | Welch *t* test | (28.77745, 396.71346) |

Figure 6C, morphine score comparison | assumed normal distribution | Welch *t* test | (105.9197, 545.6453) |

Figure 6D, sucrose jelly score comparison | assumed normal distribution | Welch *t* test | (−184.3338, 100.2870) |

Figure 6E, naloxone score comparison | assumed normal distribution | Welch *t* test | (−282.3449, 237.6449) |

Figure 6F, alcohol jelly score comparison | assumed normal distribution | Welch *t* test | (−540.5, 91.60) |

Figure 8A | assumed normal distribution | two-sample *t* test (equal variance) | (−37.92, 34.74) |

Figure 8B | assumed normal distribution | two-sample *t* test (equal variance) | (−6.048, 3.976) |

Figure 8C | assumed normal distribution | two-sample *t* test (equal variance) | (−8.227, 5.784) |

Figure 8D | assumed normal distribution | two-sample *t* test (equal variance) | (−18.20, 50.83) |