Figure | Description | Data structure | Type of test | Exact p value | |
---|---|---|---|---|---|

a | 1B | Weights-effect of genotype | Normal distribution | Two-way repeated-measures ANOVA | p = 0.26 |

b | 1B | Weights-effect of age | Normal distribution | Two-way repeated-measures ANOVA | p < 0.0001 |

c | 1B | Weights-genotype × age interaction | Normal distribution | Two-way repeated-measures ANOVA | p = 0.002 |

d | 1C | GFAP+ cells | Normal distribution | t test | p = 0.08 |

e | 2C | BrdU+ cells in DG: effect of genotype | Normal distribution | Two-way ANOVA | p < 0.0001 |

f | 2C | BrdU+ cells in DG: effect of treatment duration | Normal distribution | Two-way ANOVA | p < 0.0001 |

g | 2C | BrdU+ cells in DG: genotype × treatment duration interaction | Normal distribution | Two-way ANOVA | p = 0.17 |

h | 2F | DCX+ cells in DG: effect of genotype | Assumed normal distribution | Two-way ANOVA | p < 0.0001 |

i | 2F | DCX+ cells in DG: genotype × recovery period interaction | Assumed normal distribution | Two-way ANOVA | p = 0.0002 |

j | 2F | DCX+ cells in DG-TK 4 week and 8 week recovery vs 0 week | Assumed normal distribution | Sidak post hoc tests | p < 0.0001 |

k | 2F | DCX+ cells in DG-TK 4 week recovery vs TK 8 week recovery | Assumed normal distribution | Sidak post hoc test | p = 0.2652 |

l | 3D | BrdU+ cells in olfactory bulb-GCL | Normal distribution | t test | p < 0.0001 |

m | 3D | BrdU+ cells in olfactory bulb-EPL | Normal distribution | t test | p = 0.4 |

n | 3D | BrdU+ cells in olfactory bulb-GL | Normal distribution | t test | p = 0.002 |

o | 4A | Open-field behavior test-zones: effect of genotype | Assumed normal distribution | Two-way repeated-measures ANOVA | p = 0.7 |

p | 4A | Open-field behavior test-zones: effect of zone | Assumed normal distribution | 2 way repeated measures ANOVA | p < 0.0001 |

q | 4A | Open-field behavior test-zones: genotype × zone interaction | Assumed normal distribution | Two-way repeated-measures ANOVA | p = 1 |

r | 4A | Open-field behavior test-distance traveled: effect of genotype | Assumed normal distribution | Two-way repeated-measures ANOVA | p = 0.8 |

s | 4A | Open-field behavior test-distance travelled: effect of time | Assumed normal distribution | Two-way repeated-measures ANOVA | p < 0.001 |

t | 4A | Open-field behavior test-distance traveled: genotype × time interaction | Assumed normal distribution | Two-way repeated-measures ANOVA | p = 1 |

u | 4B | Novelty suppressed feeding test-latency: effect of genotype | Normal and potentially non-normal groups | Two-way ANOVA | p = 0.6 |

v | 4B | Novelty suppressed feeding test-latency: effect of restraint | Normal and potentially non-normal groups | Two-way ANOVA | p < 0.0001 |

w | 4B | Novelty suppressed feeding test-latency: genotype × restraint interaction | Normal and potentially non-normal groups | Two-way ANOVA | p = 0.7 |

x | 4B | Novelty suppressed feeding test-latency: distribution of feeding latencies (survival analyses) | Normal and potentially non-normal groups | Log rank test (Mantel–Cox) | p = 0.04 |

y | 4B | Novelty suppressed feeding test-latency: distribution of feeding latencies (survival analyses): v-WT control vs v-WT restraint | Normal and potentially non-normal groups | Log rank test (Mantel–Cox) | p = 0.02 |

z | 4B | Novelty suppressed feeding test-latency: distribution of feeding latencies (survival analyses): v-TK control vs v-TK restraint | Normal and potentially non-normal groups | Log rank test (Mantel–Cox) | p = 0.2 |

aa | 4C | Sucrose preference-habituation preference | Normal distribution | t test | p = 0.02 |

bb | 4C | Sucrose preference-habituation consumption: effect of genotype | Normal distribution | Two-way repeated-measures ANOVA | p = 0.3 |

cc | 4C | Sucrose preference-habituation consumption: effect of solution | Normal distribution | Two-way repeated-measures ANOVA | p < 0.0001 |

dd | 4C | Sucrose preference-habituation consumption: interaction | Normal distribution | Two-way repeated-measures ANOVA | p = 0.007 |

ee | 4C | Sucrose preference-habituation consumption-v-WT vs v-TK water | Normal distribution | Two-way repeated-measures ANOVA with Sidak post hoc | p = 0.4 |

ff | 4C | Sucrose preference-habituation consumption: v-WT vs v-TK sucrose | Normal distribution | Two-way repeated-measures ANOVA with Sidak post hoc | p = 0.01 |

gg | 4C | Sucrose preference acute 10 min test | Normal distribution | t test | p = 0.03 |