Table 3:

Drugs that affected IMI slope

Drug name[Drug][Ca]NeuromodulatornIMI slope (nS)
W70 µm13 mmProctolin12−21.7 ± 3.7
0.1 µm13 mm Proctolin5−13.5 ± 4.2
1 µm13 mmProctolin6−11.2 ± 2.4*
10 µm13 mmProctolin6−11.4 ± 3.9**
100 µm13 mmProctolin6+13.1 ± 3.4***
Calmidazolium0 µm13 mmProctolin6−20.4 ± 10.6
0.1 µm13 mmProctolin2−13.7 ± 11.1
0.3 µm13 mmProctolin6+1.6 ± 14
0.0 µm13 mmProctolin4+4.3 ± 4.9
Dantrolene0 µm13 mmProctolin6−8.1 ± 3.2
3.3 µm 13 mm Proctolin6+1.6 ± 1.9**
CALP10 µm 2 mm Proctolin11+18.2 ± 4.9
1 µm 2 mm Proctolin4+10.2 ± 6.4
10 µm 2 mm Proctolin4+28.2 ± 3.8
50 µm 2 mm Proctolin2+23.5 ± 9.4
KN-930 µm 13 mm Proctolin7−21 ± 4.2
Low dose13 mm Proctolin5+0.8 ± 5.8
High dose13 mm Proctolin2+16.6 ± 2.2
Pertussis toxin0 µg/ml13 mm Proctolin7−3.1 ± 2.9
0 µg/ml2 mm Proctolin6+14.4 ± 3.1
10 µg/ml13 mm Proctolin7+1.5 ± 2.9
10 µg/ml2 mm Proctolin6+21.5 ± 3.1
GTPγS0 mm 13 mm Proctolin9−2.2 ± 2.9
0 mm 2 mm Proctolin8+11.5 ± 3.1
10 mm 13 mm Proctolin5−6.7 ± 4.0
10 mm 2 mm Proctolin4+15.2 ± 4.4
Gallein0 µm 13 mm Proctolin9−5.4 ± 1.6
1 µm 13 mm Proctolin9+1.5 ± 1.9*
3 µm 13 mm Proctolin9+0.7 ± 2.8
ML-70 µm 13 mm Proctolin12−4.2 ± 1.5
0.1 µm 13 mm Proctolin12+1.7 ± 2.3*
1 µm 13 mm Proctolin10+4.5 ± 1.4***
10 µm 13 mm Proctolin7+3.1 ± 2.4*
Dynasore, W70, 0 µm 13 mm CCAP18−11.3 ± 1.3
0, 33 µm 13 mm CCAP6−0.4 ± 2.3***
33, 0 µm 13 mm CCAP6−12.6 ± 2.3
33, 33 µm 13 mm CCAP6−7.7 ± 2.3†
R5680 µm 13 mm Proctolin10−0.7 ± 4.5
0 µm 2 mm Proctolin6+16.5 ± 5.9
10 µm 13 mm Proctolin4+17.3 ± 7.2*
10 µm 2 mm Proctolin4+36.9 ± 7.2‡

  • Data are reported as the mean ± SEM. All data were obtained from LP neurons.

  • Tukey’s test/t test p value vs control: *p < 0.05, **p < 0.01, ***p < 0.001; †p < 0.05 vs W7 alone; ‡p < 0.05 vs low-calcium control.