Data structure | Type of test | Power | |
---|---|---|---|

Figure 2A Increased proBDNF 3 h post-SE (HA immunoreactivity) | Normal distribution | Student’s t test | 0.9775 |

Figure 2B Increased proBDNF 24 h post-SE (HA immunoreactivity) | Normal distribution | Student’s t test | 0.9917 |

Figure 3A Increased proBDNF 3 h post-SE (commercial BDNF antibodies) | Normal distribution | Student’s t test | 1.0000 |

Figure 3B Increased proBDNF 24 h post-SE (commercial BDNF antibodies) | Normal distribution | Student’s t test | 0.9104 |

Figure 5A No change in furin 3 h post-SE | Normal distribution | Student’s t test | 0.0511 |

Figure 5B Significant increase in furin 24 h post-SE | Normal distribution | Student’s t test | 0.9198 |

Figure 5C No change in plasminogen 3 h post-SE | Normal distribution | Student’s t test | 0.5067 |

Figure 5D No change in plasminogen 24 h post-SE | Normal distribution | Student’s t test | 0.6526 |

Figure 5E No change in MMP-9 3 h post-SE | Normal distribution | Student’s t test | 0.1905 |

Figure 5F No change in MMP-9 24 h post-SE | Normal distribution | Student’s t test | 0.2765 |

Figure 5G Significant reduction in tPA 3 h post-SE | Normal distribution | Student’s t test | 0.9394 |

Figure 5H Significant reduction in tPA 24 h post-SE | Normal distribution | Student’s t test | 1.0000 |

Figure 6A No change in A2AP 3 h post-SE | Normal distribution | Student’s t test | 0.5646 |

Figure 6B No change in A2AP 24 h post-SE | Normal distribution | Student’s t test | 0.1068 |

Figure 6C Reduction in neuroserpin at 3 h post-SE | Normal distribution | Student’s t test | 0.9961 |

Figure 6D No change in neuroserpin at 24 h post-SE | Normal distribution | Student’s t test | 0.0744 |

Figure 6E No change in 23 kDa nonglycosylated TIMP-1 at 3 h post-SE | Normal distribution | Student’s t test | 0.1867 |

Figure 6E No change in 28 kDa glycosylated TIMP-1 at 3 h post-SE | Normal distribution | Student’s t test | 0.5007 |

Figure 6F No change in 23 kDa nonglycosylated TIMP-1 at 24 h post-SE | Normal distribution | Student’s t test | 0.6078 |

Figure 6F Significant reduction in 28 kDa glycosylated TIMP-1 at 24 h post-SE | Normal distribution | Student’s t test | 0.9987 |

Figure 6G Significant increase in PAI-1 at 3 h post-SE | Normal distribution | Student’s t test | 0.9601 |

Figure 6H Significant increase in PAI-1 at 24 h post-SE | Normal distribution | Student’s t test | 1.0000 |

Figure 7A Increased proBDNF 3 d post-SE (commercial BDNF antibodies) | Normal distribution | Student’s t test | 0.971 |

Figure 7A Increased proBDNF 7 d post-SE (commercial BDNF antibodies) | Normal distribution | Student’s t test | 1.000 |

Figure 7B Increased PAI-1 3 d post-SE (commercial BDNF antibodies) | Non-normal distribution | Mann–Whitney test | N/A |

Figure 7B No change in PAI-1 7 d post-SE (commercial BDNF antibodies) | Normal distribution | Student’s t test | 0.985 |

Figure 7C No change in tPA 3 d post-SE (commercial BDNF antibodies) | Normal distribution | Student’s t test | 0.981 |

Figure 7C Increased tPA 7 d post-SE (commercial BDNF antibodies) | Normal distribution | Student’s t test | 1.000 |

Figure 8 PAI-1 inhibition reduces proBDNF levels after pilocarpine SE | N/A | Paired t test | 0.995 |