Figure | Panel | Data structure# | Test type | p value |
---|---|---|---|---|

2 | A^{i} | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.05 |

A
^{ii} | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.001 | |

A
^{iii} | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.01 | |

3 | B | Normal | Students t test | p=0.0047 |

4 | A | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.001 |

C | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.05 | |

D | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.05 | |

E | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.05 | |

F | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.01 | |

5 | C | Normal | Students t test | p=0.001 |

6 | C | Normal | Students t test | p=0.0537 |

8 | A | Normal | Students t test | p=0.0438 |

B | Normal | Students t test | p=0.0001 | |

C | Normal | Students t test | p=0.0353 | |

9 | A | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.001 |

B | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.05 | |

C | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.05 | |

D | Normal | Two-way ANOVA, Bonferoni post hoc | p<0.05 | |

10 | A | Normal | Students t test | p=0.0277 |

B | Normal | Students t test | p=0.0255 | |

C | Normal | Students t test | p=0.0288 | |

D | Normal | Students t test | p=0.0124 | |

E | Normal | Students t test | p=0.0156 | |

F | Normal | Students t test | p=0.0153 | |

11 | C | Normal | One-way ANOVA, Dunnett post hoc | p=0.0003 |

12 | C | Normal | One-way ANOVA, Dunnett post hoc | p=0.0273 |

13 | C | Normal | One-way ANOVA, Dunnett post hoc | p=0.0047 |

14 | A | Normal | One-way ANOVA, Dunnett post hoc | p=0.0019 |

B | Normal | One-way ANOVA, Dunnett post hoc | p=0.0001 |

Statistical analysis was performed using GraphPad Prism6.

#Kolmogorovâ€“Smirnov test (with Lilliefors correction) was used to test for normality within each group.