a (Fig. 2B) | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

b (Fig. 2C) | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

c (Fig. 2E) | Normally distributed | Student’s *t* test | 1 |

d | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

e | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

f | Normally distributed | Student’s *t* test | 0.05241 |

g | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

h | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

i (Fig. 4B) | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

j (Fig. 4C) | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

k | Normally distributed | ANOVA followed by Bonferroni’s test | 0.07662 |

l | Normally distributed | ANOVA followed by Bonferroni’s test | 0.15701 |

m (Fig. 5B) | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

n | Normally distributed | ANOVA followed by Bonferroni’s test | 0.15085 |

o | Normally distributed | ANOVA followed by Bonferroni’s test | 0.13093 |

p (Fig. 7C) | Normally distributed | Student’s *t* test | 1 |

q (Fig. 7D) | Normally distributed | Student’s *t* test | 1 |

r (Fig. 7D) | Normally distributed | Student’s *t* test | 1 |

s (Fig. 7E) | Normally distributed | Student’s *t* test | 1 |

t (Fig. 8B) | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

u (Fig. 8D) | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

v (Fig. 8E) | Normally distributed | ANOVA followed by Bonferroni’s test | 1 |

w | Normally distributed | Student’s *t* test | 0.05575 |

x | Normally distributed | Student’s *t* test | 0.0937 |

y | Normally distributed | Student’s *t* test | 1 |

z | Normally distributed | Student’s *t* test | 0.99976 |

aa | Normally distributed | Student’s *t* test | 0.0588 |

bb | Normally distributed | Student’s *t* test | 0.13625 |