Table 2.

Body and brain weight of NEX-Tsc2 mice at P0 and P10

GenotypeP0P10
Body weight (g)Brain weight (g)Body weight (g)Brain weight (g)
WT1.48 ± 0.03
(n = 23)
0.12 ± 0.00
(n = 23)
5.74 ± 0.11
(n = 23)
0.36 ± 0.00
(n = 22)
HT1.38 ± 0.07
(n = 4)
0.12 ± 0.01
(n = 4)
6.14 ± 0.2
(n = 13)
0.36 ± 0.01
(n = 10)
KO1.36 ± 0.06
(n = 5)
0.12 ± 0.01
(n = 5)
4.00 ± 0.36*
(n = 7)
0.36 ± 0.01
(n = 5)
WT + RAD001NDND3.03 ± 0.34
(n = 4)
0.19 ± 0.01
(n = 4)
HT + RAD001NDND3.27 ± 0.09
(n = 10)
0.21 ± 0.00
(n = 10)
KO + RAD001NDND2.80 ± 0.26
(n = 3)
0.21 ± 0.00
(n = 3)
  • Values indicate the average weight ± SEM. ND, Not determined.

  • *Statistically significant difference between KO and WT mice in the untreated group (Kruskal–Wallis test, p < 0.001p).