Estradiol-induced PR-ir cells in the VMN and MPA that express coactivators have greater immunostaining intensity than PR-ir cells that lack coactivators
Brain region | Genotype | PR only cells | PR cells SRC-1 and SRC-2 | PR cells SRC-1 | PR cells SRC-2 |
---|---|---|---|---|---|
VMN | wt | 22 ± 1.9 | 39 ± 6.7* | 30 ± 3.6 | 37 ± 4.7* |
PRBKO | 22 ± 3 | 36 ± 7.1 | 28 ± 4 | 34 ± 5.1* | |
PRAKO | 17 ± 3.1 | 16 ± 1.4 | 15 ± 0.9 | 16 ± 1.2 | |
ARC | wt | 24 ± 1.4 | 28 ± 2.1 | 24 ± 1.5 | 27 ± 1.2 |
PRBKO | 34 ± 8.9 | 25 ± 1.2 | 23 ± 1.2 | 29 ± 5.4 | |
MPA | wt | 18 ± 1.1 | 25 ± 1.8* | 22 ± 1.3* | 22 ± 1.3* |
Values are given as the mean intensity ± SEM. In the VMN of wt and PRBKO mice, PR-ir cells that express SRC-2 have greater immunostaining intensity than PR-ir cells that lack SRC-2. In the MPA of wt mice, estradiol-induced PR-ir cells that express SRC-1 and/or SRC-2 have higher immunostaining intensity than PR-ir cells lacking these coactivators.
↵*p < 0.05, for differences between PR-only cell types.