Measures of progranulin levels
| Row | Figure | Panel | Description | Test | Power for 30% change | 70% power to detect change of: | 80% power to detect change of: |
|---|---|---|---|---|---|---|---|
| Measures of progranulin levels | |||||||
| a | 1 | D | Frontal cortex progranulin | Student's t test | 0.93 | 22% | 24% |
| b | 1 | E | Hippocampus progranulin | Student's t test | 0.98 | 18% | 21% |
| c | 1 | F | Plasma progranulin | Student's t test | 0.82 | 26% | 29% |
| d | 3 | A | Frontal cortex progranulin mRNA | Two-way ANOVA, Sidak's post hoc test | 1 | 5% | 6% |
| e | 3 | B | Thalamus progranulin mRNA | Two-way ANOVA, Sidak's post hoc test | 1 | 8% | 9% |
| f | 3 | C | Hippocampus progranulin | Two-way ANOVA, Sidak's post hoc test | 1 | 11% | 12% |
| g | 3 | D | Plasma progranulin | Two-way ANOVA, Sidak's post hoc test | 1 | 15% | 17% |
| h | 4 | B | Frontal Cortex progranulin | Student's t test | 1 | 15% | 17% |
| i | 4 | C | Thalamus progranulin | Student's t test | 1 | 8% | 9% |
| j | 4 | D | Hippocampus progranulin | Student's t test | 1 | 14% | 16% |
| k | 5 | B | Frontal Cortex progranulin | Two-way ANOVA, Sidak's post hoc test | 0.35 | 47% | 54% |
| l | 5 | C | Hippocampus progranulin | Two-way ANOVA, Sidak's post hoc test | 0.52 | 37% | 42% |
| Exercise-related positive controls | |||||||
| m | 1 | B | Hippocampus BDNF | Student's t test | 0.57 | 35% | 39% |
| n | 1 | B | Hippocampus α-tubulin | Student's t test | 1 | 9% | 10% |
| o | 2 | A | Running distance | Two-way Repeated Measures ANOVA | 0.50 | 2092 m (38% change) | 2360 m (43% change) |
| p | 2 | B | Body weight | Two-way ANOVA, Sidak's post hoc test | 0.97 | 6.5 g (22% change) | 7.3 g (25% change) |
| q | 3 | E | Hippocampus BDNF | Two-way ANOVA, Sidak's post hoc test | 0.56 | 35% | 40% |
| r | 3 | F | Hippocampus α-tubulin | Two-way ANOVA, Sidak's post hoc test | 0.84 | 25% | 29% |
| s | 3 | G | Dentate gyrus doublecortin-positive neurons | Two-way ANOVA, Sidak's post hoc test | 0.38 | 8.3 cells (45% change) | 9.4 cells (51% change) |
| t | 4 | E | Dentate gyrus doublecortin-positive neurons | Student's t test | 0.10 | 33.9 cells (113% increase) | 38.3 cells (127% increase) |
| u | 4 | D | Hippocampus BDNF | Two-way ANOVA, Sidak's post-hoc test | 0.85 | 25% | 28% |
| v | 5 | E | Hippocampus α-tubulin | Two-way ANOVA, Sidak's post-hoc test | 1 | 7% | 8% |