Data structure | Type of test | Power | |
---|---|---|---|
a | Natural log of HIF1 alpha protein has a normal and homoscedastic distribution and was used as outcome variable | ANOVA followed by Tukey multiple comparisons of means | Peak EAE vs control = 0.99;Peak EAE vs pre-onset EAE = 0.999;Pre-onset EAE vs Control = 0.10 |
b | Normal distribution | Holm’s test | 0.911 |
c | Normal distribution | Holm’s test | >0.99 |
d | Normal distribution | Holm’s test | 0.89 |
e | Natural log of luciferase activity has a normal and homoscedastic distribution and was used as outcome variable | ANOVA followed by Tukey multiple comparisons of means | CFA+PTX vs control = 0.37;MOG+CFA+PTX vs control = 0.99;MOG+CFA+PTX vs CFA+PTX = 0.99 |
f | Non-normal distribution | Mixed-effects model | 0.64 |
g | Non-normal distribution | Mixed-effects model | 0.17 |
h | Non-normal distribution | Fisher’s exact test | 0.06 |
i | Non-normal distribution | Mixed-effects model | 0.46 |
j | Non-normal distribution | Mixed-effects model | 0.08 |
k | Non-normal distribution | Fisher’s exact test | 0.05 |
l | Normal distribution | Student’s t test | 0.18 |
m | Normal distribution | Student’s t test | 0.30 |
n | Normal distribution | Student’s t test | 0.26 |
o | Normal distribution | Student’s t test with Welch’s correction | 0.98 |
p | Normal distribution | Student’s t test with Holm’s test | 0.50 |
q | Normal distribution | Student’s t test with Holm’s test | 0.67 |
r | Normal distribution | Student’s t test with Holm’s test | 0.26 |
s | Non-normal distribution | Mixed-effects model | 0.08 |
t | Non-normal distribution | Mixed-effects model | 0.47 |
u | Non-normal distribution | Fisher’s exact test | 0.06 |
v | Non-normal distribution | Mixed-effects model | 0.61 |
w | Non-normal distribution | Mixed-effects model | 0.03 |
x | Non-normal distribution | Fisher’s exact test | 0.22 |
y | Normal distribution | ANOVA | HIF-1α^{fl/fl} vs lysM-Cre:HIF-1α^{fl/fl} = 0.03;HIF-1α^{fl/fl} vs GFAP-Cre:HIF-1α^{fl/fl} = 0.02;lysM-Cre:HIF-1α^{fl/fl} vs GFAP-Cre:HIF-1α^{fl/fl} = 0.03 |
Superscript letters refer to the statistical tests in figures, Results, and Table 1.